STAM2 Antibody

1. The authors propose a structural organization where the AMSH-SH3 binding motif interacts with the STAM2-SH3 domain and contributes to the correct positioning of AMSH prior to polyubiquitin chains' cleavage. PMID: 27725184
2. The VHS domain of STAM2 directs AMSH to cleave longer Lys63-linked ubiquitin chains PMID: 26601948
3. correlation between the percentage of STAM2-positive cells and mitotic count was statistically significant in Gastrointestinal stromal tumors PMID: 24778033
4. The study reports the solution NMR structure of the STAM2-VHS domain in complex with monoubiquitin by means of chemical shift perturbations, spin relaxation, and paramagnetic relaxation enhancements. PMID: 21121635
5. the SH3 domain of STAM2 plays versatile roles in the context of ubiquitin mediated receptor sorting PMID: 22841719
6. Mice carrying a gene trap insertion in the Stam2 transgene do not reveal phenotype changes; therefore, STAM2 function in the digestive tube remains elusive. PMID: 22140097
7. report the interactions of the UIM domain and VHS-UIM construct of STAM2 with monoubiquitin (Ub), Lys(48)- and Lys(63)-linked diubiquitins. PMID: 22493438
8. PTP1B targets the endosomal sorting machinery; dephosphorylation of regulatory sites on the endosomal sorting complex is required for transport component STAM2 PMID: 20504764
9. Data suggested that association with hepatocyte growth factor-regulated tyrosine kinase substrate is a prerequisite for STAM2 function in early endosome. PMID: 15113837
10. Rin1 regulates EGFR degradation in cooperation with STAM PMID: 17403676
11. STAMs function prominently in endoplasmic reticulum-to-Golgi trafficking, most likely through direct interactions with the coat protein II complex PMID: 19054391

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HGNC: 11358

OMIM: 606244

KEGG: hsa:10254

STRING: 9606.ENSP00000263904

UniGene: Hs.17200