STAM2 Antibody

Datasheet

Code	CSB-PA022793ESR2HU
Size	US$166
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Image	Western blot All lanes: STAM2 antibody at 4.09µg/ml Lane 1: 293T whole cell lysate Lane 2: Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 59, 39 kDa Observed band size: 59 kDa Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA022793ESR2HU at dilution of 1:100 Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA022793ESR2HU at dilution of 1:100
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) STAM2 Polyclonal antibody

Uniprot No.

O75886

Target Names

STAM2

Alternative Names

DKFZp564C047 antibody; Hbp antibody; Hrs-binding protein antibody; HSE1 homolog antibody; Signal transducing adapter molecule 2 antibody; Signal transducing adaptor molecule (SH3 domain and ITAM motif) 2 antibody; Signal transducing adaptor molecule 2A antibody; Signal transducing adaptor molecule 2B antibody; Signal transducing adaptor molecule antibody; STAM like protein containing SH3 and ITAM domains 2 antibody; STAM-2 antibody; Stam2 antibody; STAM2_HUMAN antibody; STAM2A antibody; STAM2B antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Signal transducing adapter molecule 2 protein (376-525AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Clonality

Polyclonal

Isotype

IgG

Purification Method

Antigen Affinity Purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form

Liquid

Tested Applications

ELISA, WB, IHC

Recommended Dilution

Application	Recommended Dilution
WB	1:1000-1:5000
IHC	1:20-1:200

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

Gene References into Functions

The authors propose a structural organization where the AMSH-SH3 binding motif interacts with the STAM2-SH3 domain and contributes to the correct positioning of AMSH prior to polyubiquitin chains' cleavage. PMID: 27725184
The VHS domain of STAM2 directs AMSH to cleave longer Lys63-linked ubiquitin chains PMID: 26601948
correlation between the percentage of STAM2-positive cells and mitotic count was statistically significant in Gastrointestinal stromal tumors PMID: 24778033
The study reports the solution NMR structure of the STAM2-VHS domain in complex with monoubiquitin by means of chemical shift perturbations, spin relaxation, and paramagnetic relaxation enhancements. PMID: 21121635
the SH3 domain of STAM2 plays versatile roles in the context of ubiquitin mediated receptor sorting PMID: 22841719
Mice carrying a gene trap insertion in the Stam2 transgene do not reveal phenotype changes; therefore, STAM2 function in the digestive tube remains elusive. PMID: 22140097
report the interactions of the UIM domain and VHS-UIM construct of STAM2 with monoubiquitin (Ub), Lys(48)- and Lys(63)-linked diubiquitins. PMID: 22493438
PTP1B targets the endosomal sorting machinery; dephosphorylation of regulatory sites on the endosomal sorting complex is required for transport component STAM2 PMID: 20504764
Data suggested that association with hepatocyte growth factor-regulated tyrosine kinase substrate is a prerequisite for STAM2 function in early endosome. PMID: 15113837
Rin1 regulates EGFR degradation in cooperation with STAM PMID: 17403676
STAMs function prominently in endoplasmic reticulum-to-Golgi trafficking, most likely through direct interactions with the coat protein II complex PMID: 19054391

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Subcellular Location

Cytoplasm. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.

Protein Families

STAM family

Tissue Specificity

Ubiquitously expressed.

Database Links

HGNC: 11358

OMIM: 606244

KEGG: hsa:10254

STRING: 9606.ENSP00000263904

UniGene: Hs.17200

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Jak-STAT signaling pathway Endocytosis

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