SULT2B1 Antibody

Code CSB-PA158594
Size US$299 How to order?
Image
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA158594(SULT2B1 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: ×200)
  • Gel: 8%SDS-PAGE, Lysate: 60 μg, Lane: 231 cells, Primary antibody: CSB-PA158594(SULT2B1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 minutes
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Product Details

Uniprot No. O00204
Target Names SULT2B1
Alternative Names Alcohol sulfotransferase antibody; EC 2.8.2.2 antibody; HSST2 antibody; Hydroxysteroid sulfotransferase 2 antibody; ST2B1 antibody; ST2B1_HUMAN antibody; Sulfotransferase 2B1 antibody; Sulfotransferase family cytosolic 2B member 1 antibody; SULT2B1 antibody; SULT2B1a antibody; SULT2B1b antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Fusion protein of Human SULT2B1
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method Antigen affinity purification
Concentration It differs from different batches. Please contact us to confirm it.
Buffer -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form Liquid
Tested Applications ELISA,WB,IHC
Recommended Dilution
Application Recommended Dilution
ELISA 1:2000-1:5000
WB 1:500-1:2000
IHC 1:10-1:50
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Responsible for the sulfation of cholesterol. Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA). Preferentially sulfonates cholesterol, while it has also significant activity with pregnenolone and DHEA. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation.; Sulfonates pregnenolone but not cholesterol.
Gene References into Functions
  1. findings showed clearly the impact of genetic polymorphisms on the cholesterol-sulphating activity of SULT2B1b allozymes, which may underscore the differential metabolism of cholesterol in individuals with different SULT2B1b genotypes PMID: 29701841
  2. Mutation in SULT2B1 leads to an autosomal-recessive congenital ichthyosis phenotype via increased proliferation of human keratinocytes, thickening of epithelial layers, and altered epidermal cholesterol metabolism. PMID: 28575648
  3. Since 1'-hydroxyestragole exposure readily produced DNA injury in B-13/H cells, these data suggest that cholangiocarcinomas generated in rats fed estragole may be dependent, in part, on SULT2B1 activation of the 1'-hydroxyestragole metabolite. PMID: 26739637
  4. Overexpression of SULT2B1b is an independent prognostic indicator and promotes cell growth and invasion in colorectal carcinoma. PMID: 26121319
  5. This study identified specific germline variations in estradiol metabolism-related pathways, namely CYP1B1, SULT2B1, and HSD17B2, as novel prognostic markers that are cumulatively associated with increased risk of prostate cancer progression PMID: 24682418
  6. The SULT2B1 isoforms have a unique 50 amino acid carboxy-terminal sequence that is not present in the other human SULT isoforms (review). PMID: 24020383
  7. Data indicate that cholesterol sulfate (CS) and SULT2B1b inhibited gluconeogenesis by targeting the gluconeogenic factor hepatocyte nuclear factor 4alpha (HNF4alpha) in both cell cultures and human SULT2B1b transgenic mice. PMID: 24277929
  8. SULT2B1 is induced by calcitriol activated vitamin D receptor in human prostate cancer cells. PMID: 23579488
  9. SULT2B1b expression promotes proliferation of hepatocellular carcinoma cells in vitro and in vivo, which may contribute to the progression of HCC. PMID: 23593328
  10. In HT29 cells expression of SULT2B1 was enhanced by probiotic fermentation supernatants without aleurone. PMID: 21840698
  11. The Ca(2+)-bound form may be physiologically relevant for stressed cells with an elevated free calcium level. PMID: 20329768
  12. The expression of SULT2B1b mRNA in endometrial stromal cells is induced by progesterone and that in endometrial epithelial cells is induced by relaxin via the cAMP pathway. PMID: 19243756
  13. alternative splicing of SULT2B1 results in cholesterol sulfotransferase or pregnenolone sulfotransferase PMID: 12145317
  14. crystal structure of hydroxysteroid sulfotransferases SULT2B1a and SULT2B1b bound to the substrate donor product 3'-phosphoadenosine 5'-phosphate and acceptor substrate pregnenolone revealed a different catalytic binding orientation PMID: 12923182
  15. We have documented the presence of the enzyme (SULT2B1b) that sulfonates cholesterol in human platelets and examined the influence of plasma lipoproteins on the expression and activity of this enzyme PMID: 14676143
  16. Differential subcellular localization of SULT2B1b in prostate and placenta suggests that SULT2B1b may be differentially regulated and have different physiological functions in these two hormonally responsive human tissues PMID: 14741047
  17. confinement of SULT2B1b to the granular layer coincides with this being the area with the highest cholesterol sulfate content suggesting that the physiologic action of cholesterol sulfate is likely carried out in this region of the living epidermis PMID: 15140224
  18. Immunohistochemical localization of SULT2B1b in human tissues showed expression in the cytoplasm of ciliated columnar or cuboidal epithelial cells in terminal bronchia. PMID: 15878639
  19. Of five Sp1 elements identified in SULT2B1, two had regulatory activity utilizing immortalized human keratinocytes. PMID: 15953604
  20. SULT2B1b, by acting on a variety of oxysterols, offers a potential pathway for modulating in vivo the injurious effects of these compounds. PMID: 17347498
  21. Results show SULT2B1 polymorpohisms affect enzyme functions. PMID: 17496163
  22. SULT2B1 is involved in reulating prostate cell responsiveness to dehydroepiandrosterone and delta5-androstenediol. PMID: 17626250
  23. Data show that SULT2B1b is localized in cytosol and nuclei of cancerous and normal breast tissue, and that African Americans had significantly more SULT2B1b in nuclei of epithelial cells of normal breast tissue compared to Caucasians. PMID: 18586095

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Involvement in disease Ichthyosis, congenital, autosomal recessive 14 (ARCI14)
Subcellular Location Cytoplasm, cytosol. Microsome. Nucleus.
Protein Families Sulfotransferase 1 family
Tissue Specificity Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.
Database Links

HGNC: 11459

OMIM: 604125

KEGG: hsa:6820

STRING: 9606.ENSP00000201586

UniGene: Hs.369331

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