TET3 Antibody

Code CSB-PA023398LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA023398LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA023398LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TET3 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
hCG_40738 antibody; KIAA0401 antibody; Methylcytosine dioxygenase TET3 antibody; Probable methylcytosine dioxygenase TET3 antibody; Tet methylcytosine dioxygenase 3 antibody; Tet oncogene family member 3 antibody; Tet3 antibody; TET3_HUMAN antibody
Raised in
Species Reactivity
Recombinant Human Methylcytosine dioxygenase TET3 protein (72-335AA)
Immunogen Species
Homo sapiens (Human)

The TET3 Antibody (Product code: CSB-PA023398LA01HU) is Non-conjugated. For TET3 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA023398LB01HU TET3 Antibody, HRP conjugated ELISA
FITC CSB-PA023398LC01HU TET3 Antibody, FITC conjugated
Biotin CSB-PA023398LD01HU TET3 Antibody, Biotin conjugated ELISA
Purification Method
>95%, Protein G purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Tested Applications
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG.
Gene References into Functions
  1. High mRNA levels of TET3 is independent predictor of poor outcome in Renal Cell Carcinoma patients. PMID: 28069330
  2. TET3 interacts with different members of the thyroid hormone nuclear receptors superfamily and also enhances their association to chromatin. PMID: 28716910
  3. TET3-5-hydroxymethylcytosine was upregulated in the femoral head tissues of SAON patients and MLO-Y4 cells with dexamethasone (Dex) treatment. PMID: 27627619
  4. Results revealed that TET3 acted as a suppressor of ovarian cancer by demethylating miR-30d precursor gene promoter to block TGF-beta1-induced epithelial-mesenchymal transition. PMID: 27141829
  5. TET3 expression inhibits glioblastoma tumorigenesis and self-renewal in glioblastoma stem cells. PMID: 26838672
  6. levels of TET3 and TDG mRNAs were independent prognostic factors for early breast cancer patients who received anthracycline chemotherapy PMID: 26207381
  7. Hypoxia deregulates TET3. TET1/3 levels were associated with tumor hypoxia, tumor malignancy, and poor prognosis in breast cancer patients. Coordinate functions of TET1 and TET3 were needed to activate TNFalpha-p38-MAPK signaling in hypoxia. PMID: 26294212
  8. In hepatic stellate cells, cell proliferation rise significantly and cell apoptosis reduce obviously after knockdown of TET3. PMID: 25550811
  9. OGT catalyzes the O-GlcNAcylation of TET3, promotes TET3 nuclear export, and, consequently, inhibits the formation of 5-hydroxymethylcytosine catalyzed by TET3. PMID: 24394411
  10. TET3 enhanced its localization to chromatin through the stabilization of OGT protein. PMID: 24304661
  11. variable association with CXXC modules may contribute to context specific functions of Tet proteins PMID: 23690950
  12. Studies indicate that the TET-family enzymes are Fe(II), 2-oxoglutarate-dependent oxygenases and catalyze demethylation of 5-methylcytosine (5mC) by iterative oxidation reactions. PMID: 23727577

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Subcellular Location
Nucleus. Cytoplasm. Chromosome.
Protein Families
TET family
Tissue Specificity
Expressed in colon, muscle, adrenal gland and peripheral blood lymphocytes.
Database Links

HGNC: 28313

OMIM: 613555

KEGG: hsa:200424

STRING: 9606.ENSP00000386869

UniGene: Hs.516107

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