UGGT1 Antibody

1. both vIL-6 and VKORC1v2 interact with calnexin cycle proteins UDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1), which catalyzes monoglucosylation of N-glycans, and oppositely acting glucosidase II (GlucII), and that vIL-6 can promote protein folding. PMID: 28878084
2. These findings provide important insight on the role of unfolded protein response (UPR) and host UGGT1 in regulating RNA virus replication and pathogenicity. PMID: 28545059
3. The results demonstrated that FAM5C is an N-glycosylated protein, and N-glycosylation by UGGT1 is necessary for the secretion of FAM5C. PMID: 28351617
4. A novel UGGT1- and p97-dependent protein quality checkpoint is shown. This checkpoint is alerted to prevent secretion of a polypeptide that passes the luminal quality control scrutiny by BiP and CNX but contains an intramembrane ionizable residue. PMID: 25694454
5. Kyte-Doolittle analysis as well as homology modeling revealed a cluster of hydrophobic amino acids that may be functional in the folding sensing mechanism of HUGT1 PMID: 26196150
6. Results indicate that glycan structures are similar to endogenous glycans at low expression levels of uridine 5'-diphosphate-glucose: glycoprotein glucosyltransferase (UGGT1). PMID: 25935482
7. The UGGT1 is a well-documented enzyme which functions as a folding sensor in the endoplasmic reticulum, by the virtue of its ability to transfer a glucose residue to non-glucosylated high-mannose-type glycans of immature glycoproteins. PMID: 24415556
8. UGT1 aids in the folding of sequential domain-containing proteins such as prosaposin. PMID: 20498017
9. The substrate binding specificity PMID: 12682060
10. the amino-terminal 80% of HUGT1 is required for activation of the catalytic domain PMID: 12913004
11. overexpression leads to increase in production of recombinant proteins; gene targeting PMID: 19466607

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HGNC: 15663

OMIM: 605897

KEGG: hsa:56886

STRING: 9606.ENSP00000259253

UniGene: Hs.743306