Recombinant Human Calcium/calmodulin-dependent protein kinase type IV (CAMK4)

1. vanillin binds strongly to the active site cavity of CAMKIV and stabilized by a large number of non-covalent interactions. PMID: 28744811
2. Genotype and allele frequencies of CAMKIV gene SNPs differed significantly between alcohol dependence patients and control subjects. The results of the present study suggest that CAMKIV might be a candidate alcohol dependence gene. PMID: 28734942
3. hTau accumulation impairs synapse and memory by CaN-mediated suppression of nuclear CaMKIV/CREB signaling. PMID: 27298345
4. Within the pH range 5.0-11.5, CAMK4 maintained both its secondary and tertiary structures, along with its function, whereas significant aggregation was observed at acidic pH (2.0-4.5). PMID: 27032767
5. A positive association was not observed between rs10491334 in the CAMK4 gene and longevity in a Chinese population. PMID: 27659345
6. The T-allele of rs10491334 in CAMK4 was associated with hypertension in the Uygur group. PMID: 26909912
7. Expression of CaMKIV inhibits autophosphorylation and activation of CaMKII, and elicits G0/G1cell cycle arrest,impairing cell proliferation. PMID: 25446257
8. An imbalance of specific isoforms of CYFIP1, an FMRP interaction partner, and CAMK4, a transcriptional regulator of the FMRP gene, modulates risk for autism spectrum disorders. PMID: 24442360
9. CaMK4-dependent activation of AKT/mTOR and CREM-alpha underlies autoimmunity-associated Th17 imbalance. PMID: 24667640
10. CaMK4 regulates beta-cell proliferation and apoptosis in a CREB-dependent manner and CaMK4-induced IRS-2 expression is important in these processes PMID: 23049845
11. study suggests that the mutations in CAMK4 may lead to abnormal semen parameters PMID: 22897820
12. Phosphorylated Notch1-IC by CaMKIV increases Notch1-IC stability, which enhances osteoclast differentiation. PMID: 23103515
13. Prolongevity genes are activated by CAMKIV, the levels of which are influenced by rs10491334, a single-nucleotide polymorphism associated with human longevity. PMID: 21612516
14. The regulation of RORalpha activity by PKA as well as CaMK-IV provides a new link in the signalling network that regulates metabolic processes such as glycogen and lipid metabolism. PMID: 21514275
15. These findings suggest that PLC/CAMK IV-NF-kappaB is involved in RAGE mediated signaling pathway in human endothelial cells. PMID: 20171262
16. CaMKIV proteins were found in the nucleus of epithelial ovarian cancer tissue. CaMKIV expression was significantly associated with clinical stage (P<0.01), histological grade (P<0.01), and clinical outcome (P<0.01). PMID: 12065094
17. sequestration of CaMKK may be the molecular mechanism by which catalytically inactive mutants of CaMKIV exert their "dominant-negative" functions within the cell PMID: 14701808
18. the Ca(2+)/CaM binding-autoinhibitory domain of CaMKIV is required for association of the kinase with PP2A PMID: 15143065
19. calcium/CaMKIV signaling pathway may play an important role in the excitation-mediated regulation of corticotropin releasing hormone synthesis PMID: 15591024
20. the function of CaMK II is essential for PAF-induced macrophage priming, while CaMK IV is not specific for priming by PAF and appears to have a direct link in TLR4-mediated events PMID: 15665723
21. CaMKIV is expressed in human sperm and may have a role in the regulation of human sperm motility PMID: 15840651
22. Results identify calcium/calmodulin-dependent kinase IV as being responsible for the increased expression of CREM and the decreased production of interleukin-2 in systemic lupus erythematosus T cells. PMID: 15841182
23. Transgenic CaMKIV plays a modulatory role in the nucleus accumbens in anxiety-like behavior of adult CaMKIV variant mice. PMID: 18053176
24. CaMK-4 expression correlates positively with the ability to form long-term memory and implicates the decline of CaMKIV signaling mechanisms in age-related memory deficits. PMID: 18829949
25. CaMKIV plays a critical role in the development and persistence of cocaine-induced behaviors, through mechanisms dissociated from acute effects on gene expression and CREB-dependent transcription. PMID: 19001277
26. hnRNP L is an essential component of CaMKIV-regulated alternative splicing through CA repeats, with its phosphorylation likely playing a critical role. PMID: 19017650
27. a group of RNA elements are responsive to PKA and CaMKIV from in vivo selection PMID: 19386606
28. CaMKIV is a molecular link between Group I mGluRs and fragile X mental retardation protein in anterior cingulate cortex neurons PMID: 19436069
29. analysis of regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification PMID: 19506079
30. these data indicate that the B subunits alpha and delta are essential for the interaction of PP2A with CaMKIV. PMID: 19538941
31. Data show that RA-induced repression of the CaMKIV signaling pathway may represent an early event in retinoid-dependent neuronal differentiation. PMID: 19633294

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HGNC: 1464

OMIM: 114080

KEGG: hsa:814

STRING: 9606.ENSP00000282356

UniGene: Hs.438801