Recombinant Human Fibrinogen beta chain(FGB),partial Yeast

Code CSB-YP008608HU
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Source Yeast
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Code CSB-EP008608HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP008608HU
Size Pls inquire other sizes
Source Baculovirus
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Code CSB-MP008608HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names FGB
Uniprot No. P02675
Alternative Names Beta fibrinogen; Epididymis Secretory Sperm Binding Protein Li 78p; FGB; FIBB_HUMAN; Fibrinogen beta chain; Fibrinogen; B Beta Polypeptide; HEL-S-78p
Species Homo sapiens (Human)
Expression Region 45-491
Protein Length partial
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Gene References into Functions
  1. High fibrinogen expression is associated with esophageal carcinoma. PMID: 29134563
  2. Compared with the patients with TT genotypes of fibrinogen beta, expressions of fibrinogen, IL-6 and CRP were significantly higher in the patients with the CC and CT genotypes. PMID: 29165755
  3. Two novel fibrinogen Bbeta chain mutations in two Slovak families with hypofibrinogenemia/afibrinogenemia have been described. PMID: 29286337
  4. FGB c.490G>A indicated the activation of a cryptic splice site causing the insertion of 99 bp in intron 3. This splicing abnormality led to the production of a Bbeta-chain possessing 33 aberrant amino acids, including two Cys residues in the coiled-coil domain. Therefore, a splicing abnormality may cause impaired fibrinogen assembly and secretion. PMID: 29156616
  5. FGB mutations leading to congenital hypofibrinogenaemia PMID: 28306188
  6. Fibrinogen Bbeta448Lys variant is associated with thrombotic fibrin clots in type 2 diabetic patients independently of traditional risk factors. PMID: 27929198
  7. There was underexpression of the majority of genes after sunitinib treatment. The lower expression levels of IGFBP1, CCL20, CXCL6 and FGB were confirmed by qRT-PCR in all cases. The downregulation of gene expression leads us to search for methylation as a mechanism of action of the tyrosine kinase inhibitors PMID: 27834463
  8. elevated levels of plasma homocysteine /homocysteine thiolactone contribute to AD pathology via the Abeta-fibrin(ogen) interaction PMID: 27090576
  9. procoagulant changes in fibrin metastructure appear to result from excessive carbonylation of fibrinogen, which may compensate for a decrease in fibrinogen level in patients with cirrhosis PMID: 26833718
  10. Prognostic impact of plasma fibrinogen levels in patients with esophageal squamous cell carcinoma PMID: 28064398
  11. a tight cluster of alternating multiple splicing regulatory elements and U1 snRNA binding sites controls cryptic splice donor usage throughout the human fibrinogen Bbeta-chain gene (FGB) exon 7 PMID: 28039323
  12. The plasma fibrinogen level was found to be a possible biomarker for clinical response to chemotherapy and postoperative metastasis or death in advanced breast cancer patients who received neoadjuvant chemotherapy PMID: 28621233
  13. Data suggest that, in the binding of fibrin beta N-domains and the (1-8) peptide fragment of VLDLR (very low density lipoprotein receptor), the second and third Lys/Arg clusters in fibrin make major contributions to this interaction while the contribution of the first cluster is moderate. PMID: 28437098
  14. The novel missense mutation in the FGB gene causes afibrinogenemia most probably by affecting the secretion of the fibrinogen beta-chain. PMID: 27824214
  15. fibrinogen aggregation is accompanied by the formation of beta-sheet conformation, and induction of non-native helical segments in the protein inhibits aggregation PMID: 27150313
  16. fibrinogen is an independent predictor of the angiographic presence of coronary artery disease in hypertensive patients. PMID: 27553289
  17. novel mutation was identified in exon 2 of FGB caused by c.221G> T (dagger) substitution PMID: 27812779
  18. Our results show that higher levels of circulating chemerin, CRP, fibrinogen, and ESR are associated with an increased risk of developing colorectal cancer PMID: 26628300
  19. We assessed the diagnostic accuracy of a newly developed laboratory score-based on CA125, platelet count (PLT), C-reactive protein (CRP), and fibrinogen levels-in the preoperative diagnosis of adnexal mass PMID: 26499778
  20. the mechanical properties of individual fibrin fibers formed from blood plasma, were examined. PMID: 27028649
  21. Here we report a new B[beta] gene mutation (Fibrinogen St Kilda) identified in two Caucasian sisters with reduced fibrinogen level (1.2-1.6 g/L) during investigation for recurrent early miscarriages. PMID: 26308135
  22. desAB fibrin binds to prothrombin through the Bbeta26-42 amino acid residues and the formation of such a complex causes a non-enzymatic activation of prothrombin PMID: 26317125
  23. Strong positive association has been found between betatrophin, plasma fibrinogen (FBG), and insulin resistance in non-diabetic subjects. Correlations with FBG and insulin resistance were diminished in type 2 diabetes subjects. PMID: 26077345
  24. These experiments demonstrate, for the FGB-p.Asp185Asn mutation, a pathogenic mechanism not common for fibrinogen deficiencies, i.e. the hyperglycosylation of the Bbeta chain due to the introduction of a novel N-glycosylation motif. PMID: 26006300
  25. High plasma fibrinogen levels and platelet count are associated with esophageal squamous cell carcinoma. PMID: 25896470
  26. Results suggest that FGB -148 C/T and -854 G/A polymorphisms probably contribute to susceptibility of ischemic stroke in Chinese population. PMID: 25890854
  27. The results of the meta-analysis indicate that the -455 G>A polymorphism in the beta-fibrinogen gene is a susceptibility marker of ischemic cerebral infarction in the Chinese population. PMID: 25398500
  28. In the present study, we found that the -148C>T polymorphism in the FGB gene was significantly associated with ischemic stroke in a Chinese population [meta-analysis] PMID: 25867317
  29. This prospective study in 110 patients undergoing major cardiovascular surgery at risk of post-cardiopulmonary bypass bleeding compares fibrinogen level. PMID: 26011420
  30. the NGR motif in fibrinogen is the site that is primarily responsible for the interaction with resting alphaIIbbeta3 and is responsible for triggering platelet activation PMID: 25413489
  31. Elevated fibrinogen levels are associated with negative tumor response to therapy in rectal cancer. PMID: 25384698
  32. Four novel FGB mutations were identified in two afibrinogenemic (one new-born and one 30 years old male) and hypofibrinogenemic (a 49 years old female) patient, with heterogeneous thrombotic and bleeding phenotype PMID: 24560896
  33. plasma fibrinogen increase during ischemic stroke has a role in worse outcome PMID: 24531853
  34. meta-analysis suggests that the FGB-455G/A polymorphism contributes to susceptibility to ischemic stroke and coronary heart disease PMID: 24448059
  35. results of our meta-analysis suggested that the-148C>T polymorphism in the FGB gene is a susceptibility marker of ischemic stroke PMID: 24720800
  36. The A + genotype of the FGB -455 G/A polymorphism associated with poor survival among 55-71 years old Caucasian women in the Finnish stroke cohort. PMID: 24957141
  37. results indicate that FGbeta-455G/A polymorphism may be a susceptible predictor of ischemic stroke [meta-analysis] PMID: 24366241
  38. Elevated fibrinogen is associated with idiopathic sudden hearing loss. PMID: 24466284
  39. High fibrinogen levels are associated with gynecologic cancer. PMID: 25204086
  40. Both fibrinogen polymorphisms are capable to modify the atherosclerotic process via their effects on the coagulation cascade. PMID: 23931975
  41. The beta-fibrinogen -455G/A gene polymorphism is not a risk factor for ischaemic stroke in a Polish population. PMID: 23650004
  42. A meta-analysis of a Chinese population found that the FgB -455G/A and the -148C/T gene polymorphism was implied to be associated with coronary artery disease susceptibility. PMID: 23129316
  43. Both isoforms of the beta-chain of FIB discovered by 2D-gel electrophoresis are decreased in the Parkinson's disease group cerebrospinal fluid, compared to normal controls. PMID: 22889670
  44. Lys, as an inhibitor of protein glycation, improved fibrinogen's structure and function, both in vitro and in vivo. PMID: 22575419
  45. Fibrinogen polymorphisms contributes to the association between common variants in the fibrinogen gene and the risk of developing sporadic cerebral hemorrhage. PMID: 22386478
  46. study found that -C148T FGB polymorphism was an independent predictor of pre- and early postoperative C-reactive protein levels in coronary artery bypass graft patients PMID: 21499712
  47. genetic polymorphism is associated with plasma fibrinogen levels and haematological traits in whites, blacks and mexican americans PMID: 22273812
  48. Levels of fibrinogen and thromboelastometry fibrin polymerisation following treatment with desmopressin (DDAVP). PMID: 22293628
  49. The BF -455G/A polymorphisms was found to be positively. PMID: 21241403
  50. Fibrinogen has chaperone activity which is compromised upon glycation by methylglyoxal. PMID: 22053176
  51. mutation presents as hypodysfibrinogenaemia due to alterations in sialic acid content PMID: 21713329
  52. genetic polymorphism is associated with delayed clot formation and more permeable fibrin network PMID: 21725578
  53. increased fibrinogen concentration in black South Africans, especially in rural areas PMID: 21800007
  54. LRP1b shows restricted expression in human tissues and binds to several extracellular ligands, including fibrinogen and apoE--carrying lipoproteins PMID: 21420681
  55. Patients with atherothrombotic stroke showed raised fibrinogen and erythrocyte sedimentation rate PMID: 21296900
  56. Clinical manifestations of acute focal neurological deficits in stroke were associated with plasma antithrombin-III and fibrinogen PMID: 21316837
  57. The allele frequencies for beta fibrinogen were similar between women with recurrent pregnancy loss and control women, suggesting that the effect of beta-fibrinogen polymorphisms on recurrent miscarriages, if any, is actually very slight. PMID: 21160146
  58. FgB beta Bcl-1A allele and variation genotype were susceptible to cerebral infarction. PMID: 19954614
  59. Data suggest that the interaction between Abeta and fibrinogen may be an important contributor to the vascular abnormalities found in Alzheimer's disease. PMID: 21098282
  60. The beta-fibrinogen -455 G>A gene polymorphism is associated with peripheral vascular injury in systemic sclerosis patients. PMID: 21122273
  61. Fg-beta455 G/A polymorphism may contribute to elevated plasma fibrinogen levels and put individuals at higher risk of having severe periodontitis. PMID: 18683729
  62. Fibrinogen gene single nucleotide polymorphisms are associated with cardiovascular diseases. PMID: 20978265
  63. fibrinogen may have a role in progression of coronary artery calcification in adults with type 1 diabetes PMID: 20079495
  64. Polymorphic markers G(-455)A of gene FGB and C(-1654)T of gene PROC and genetic predisposition to unfavorable outcomes patients undergoing acute coronary syndrome PMID: 20873219
  65. The beta-chain of fibrinogen level was found significant risk factor only for the venous thrombosis group. PMID: 20535834
  66. Plasma fibrinogen levels and fibrinogen Bbeta-148C/T polymorphism are associated with coronary artery lesions in children with Kawasaki disease. PMID: 20637145
  67. There was FGA gene 128C/G polymorphism in the Hunan Han population. There was no association of this polymorphism with the increased Fg level of CI patient in the population. PMID: 20533267
  68. The B beta -455 and -249 mutated genotypes are accumulative genes for overweight by regulating the fibrinogen function. PMID: 20376805
  69. The SNP rs4220 in FGB , which leads to the substitution of arginine by lysine at position 448, is independently associated with plasma fibrinogen level and hypertension in Hong Kong Chinese men. PMID: 20135074
  70. G-455A polymorphism of beta-fibrinogen gene and the risk of premature myocardial infarction in Greece is reported. PMID: 19409601
  71. we identified FBG-beta as a hepatitis C virus (HCV) core interacting protein by screening a human liver complementary DNA (cDNA) library PMID: 20162731
  72. There was a complete linkage disequilibrium between fibrinogen beta -148C/T and -455G/A found in Han population with pulmonary thrmoboembolism. PMID: 16750002
  73. Elevated levels of C-reactive protein and fibrinogen and reduced level of adiponectin can be used for early diagnosis of type 2 diabetes mellitus and can predict diabetic complications. PMID: 20075509
  74. FGB rs1800787 and rs1800789 SNPs seem to confer protection to coronary artery disease onset, lowering the risk by about 50% in homozygotes for the minor alleles. PMID: 20167083
  75. A single-nucleotide polymorphism in the FGB is a risk factor for cardiovascular Diseases. PMID: 20031576
  76. There was no effect of the -854G>A beta-fibrinogen promoter polymorphism on fibrinogen, but the fibrinogen -455G>A polymorphism increased fibrinogen levels following exercise. The genotype might be clinically relevant at times of hyperfibrinogenaemia. PMID: 11858186
  77. Among Iranian afirbinogenemia patients, for the first time, a nonsense mutation (3282C-->T) was found in exon 2 of the fibrinogen Bbeta-chain gene, causing truncation of the corresponding polypeptide. PMID: 12161363
  78. 2 new homozygous mutations in introns 6 & 7 represent the first Bbeta-chain splicing mutations in afibrinogenemia. IVS6 + 13C > T creates a donor splice site in intron 6. IVS7 + 1G >T removes the invariant GT of intron 7 donor splice site. PMID: 12393540
  79. The first prenatal diagnosis for afibrinogenemia found a novel nonsense mutation in the FGB gene, Trp467Stop (W467X). This confirms the need for intact C-terminal portions of FGB for the secretion of functional hexamers. PMID: 12511408
  80. frequencies of the beta-fibrinogen 448 A allele were higher in patients with no flow-limiting stenosis after myocardial infarction PMID: 12514663
  81. Fibrinogen gene promoter -455 A allele as a risk factor for lacunar stroke. PMID: 12637691
  82. Fibrinogen molecules from a compound FGB heterozygote with an N-terminal nonsense mutation W47X (exon 2) & a missense mutation (G444S, exon 8), can assemble but are not secreted, confirming the need for an intact FGB C-terminal domain for secretion. PMID: 12893758
  83. Polymorphism of BclI betaFbg gene is associated with an increased fibrinogen plasma level. 2. There is no association between BclI polymorphism of betaFbg gene and the number of affected coronary arteries PMID: 14618197
  84. suggest a possible interactive effect of cigarette smoke and the b fibrinogen gene G-455-A polymorphism in the risk of developing Legg-Perthes disease PMID: 14629463
  85. a heterozygous single point mutation of T-->G at position 3356 of the patient fibrinogen Bbeta chain gene resulted in a nonsense mutation, and also resulted in a new NheI recognition sequence at this position PMID: 14629469
  86. results demonstrate that the FGB beta -455 G/A polymorphism is not associated with myocardial infarction and the closely linked B beta Arg448Lys protein coding variation does not influence function nor structure of the protein in a purified system. PMID: 14652632
  87. the C-terminal sequences of the beta and gamma chains of fibrinogen have roles in fibrin polymerization as well as in cell attachment PMID: 14691567
  88. Erythrocyte aggregation and -455G/A polymorphism of the beta-fibrinogen gene in survivors of acute myocardial infarction. PMID: 15213870
  89. The study demonstrates that A allele of the B beta gene FGB -455G/A polymorphism may be a susceptible predictor of the occurrence of ACI, particularly in smokers. PMID: 15300640
  90. a beta-fibrinogen polymorphism may have a role in myocardial infarction PMID: 15583729
  91. the basal expression of gamma-fibrinogen is regulated by a constitutive transcriptional repressor protein, hnRNP A1, and the decreased binding activity of hnRNP A1 leads to the overexpression of gamma chain in HepG2 cells that overexpress the Bbeta chain PMID: 15671034
  92. the HNF-3 site in the fibrinogen beta promoter is important for IL6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism PMID: 15737987
  93. Dysfibrinogenemia in the family is caused by Arg275His in the beta chain of fibrinogen and it is the first report on a Chinese family with inherited dysfibrinogenemia. PMID: 15793786
  94. Bbeta-Leu353Arg is associated with impaired fibrinogen secretion, but not with hepatic endoplasmic reticulum storage disease PMID: 15842357
  95. Truncation of the seven most C-terminal residues (R455-Q461) of the Bbeta chain specifically inhibits fibrinogen secretion. PMID: 16195396
  96. FgB beta -148 and 448 mutational genotypes have impact on Fg concentrationi and therefore increase the risk of infarction. PMID: 16215953
  97. We hypothesize that the modification of lysine by Hcys thiolactone might occur in vivo, lead to abnormal resistance of clots to lysis, and thereby contribute to the prothrombotic state associated with homocysteinemia. PMID: 16489740
  98. analysis of hypofibrinogenaemia resulting from novel single nucleotide deletion at codon Bbeta58 PMID: 16601848
  99. In this work we report the identification of a strong SF2/ASF binding site within exon 7 of the human fibrinogen Bbeta-chain gene (FGB). PMID: 16611940
  100. results concord with the already shown link between fibrinogen concentration & fasting insulin concentration (FIC) & support the hypothesis of relationship between fibrinogen & endothelium in FIC homeostasis whose alteration may induce metabolic disorders PMID: 16697386

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Involvement in disease Congenital afibrinogenemia (CAFBN); Dysfibrinogenemia, congenital (DYSFIBRIN)
Subcellular Location Secreted
Tissue Specificity Detected in blood plasma (at protein level).
Database Links

HGNC: 3662

OMIM: 134830

KEGG: hsa:2244

STRING: 9606.ENSP00000306099

UniGene: Hs.300774

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