Recombinant Human Somatoliberin (GHRH)

1. c.57+1G>A mutation in the GHRH receptor gene is associated with severe and congenital isolated GH deficiency. PMID: 29571594
2. GHRH stimulates a ligand-independent activation of EGFR involving at least cAMP/PKA and Src family signaling pathways PMID: 27816751
3. GHRH analogs of the Miami series powerfully suppress tumor growth, but have only a weak endocrine GH inhibitory activity. The suppression of tumor growth could be induced in part by the downregulation of PMID: 28130121
4. Report a high rate of GHRH-R and GHRH expression in apocrine breast carcinomas. PMID: 28438614
5. GHRH and GHRH-R loops are involved in placental choriocarcinoma cell line viability and apoptosis through Akt and eIF2a pathways. PMID: 26917260
6. GHRH excess and blockade in X-LAG syndrome PMID: 26671997
7. case Report: multiple endocrine neoplasia type 1 family characterized by primary hyperparathyroidism, in association with acromegaly because of ectopic GHRH secretion by a pancreatic neuroendocrine tumor in a young man. PMID: 23542451
8. After 20 weeks of GHRH administration, gamma-aminobutyric acid levels are increased in all brain regions, N-acetylaspartylglutamate levels are increased in the dorsolateral frontal cortex, and myoinositol levels are decreased in the posterior cingulate. PMID: 23689947
9. The pathomechanisms involved in the genetic defects at both ends of the GHRH-IGF-1 axis. PMID: 22423511
10. Pretreatment with GHRH for 12 days could restore pituitary responsiveness to GHRH either in healthy aged men and growth hormone-deficient adult patients. PMID: 20843274
11. GHRH stimulated the NF-kappa b transcription factor, which is not only known to activate angiogenic factors but also the expression of genes involved in encoding enzymes in the prostaglandin-synthesis pathway such as COX-2 and the iNOS PMID: 20518847
12. GHRH mutations were not identified in a selected cohort of patients with isolated GH deficiency, suggesting that, if they exist, they may be an extremely rare cause of isolated GH deficiency. PMID: 21715545
13. The common regenerative and neuroprotective effects of epidermal growth factor (EGF) and growth hormone releasing hormone peptide(GHRP)-6 are associated with their versatile pro-survival and pro-regenerative mechanisms. PMID: 20169434
14. A single nucleotide polymorphism (SNP) in GnRH shows relationship to central precocious puberty in Chinese Han girls. PMID: 20869425
15. The present paper will give an overview of the main cardiovascular actions of the ghrelin gene-derived peptides and of GHRH. PMID: 21478211
16. Data show that GHRH can stimulate the secretion of IL-17 from human peripheral blood mononuclear cells. PMID: 21196925
17. Results demonstrate that a positive correlation exists between the endocrine potency and the antiproliferative efficacy of GHRH antagonists in tumors strongly expressing pGHRH-R. PMID: 20633588
18. the juxtapositions between GHRH axonal varicosities may be functional synapses and may represent the morphological substrate of the synchronized release of GHRH in the human hypothalamus. PMID: 20673733
19. growth hormone-releasing hormone has a role as a growth factor in diverse tissues and various tumors PMID: 20372804
20. GHRH mRNA was found in transformed human endometriotic stromal cells. PMID: 19524226
21. human GHRH is expressed in experimental prostate neoplasms in mice; this could explain the effects of GHRH antagonists on growth of prostate cancer PMID: 12126741
22. expression in gastroenteropancreatic carcinomas PMID: 12186980
23. expressed in a subset of endometrial tumors, of the endometrioid type in particular; A paracrine/autocrine role for GHRH in the development of the disease should be considered PMID: 12213676
24. presence of GHRH and its tumoral receptor splice variants in prostate cancers suggests the possible existence of an autocrine mitogenic loop PMID: 12364462
25. GHRH is essential for the somatotrope cellular proliferation that normally occurs during development-REVIEW PMID: 12424433
26. Review. Growth hormone-releasing hormone (GHRH) is a hypothalamic hormone that is essential for normal expansion of the somatotrope lineage during pituitary development. PMID: 12511850
27. autocrine stimulatory loop between GHRH and SV1 variant of GHRH receptor in primary breast cancers PMID: 15362970
28. Endogenous GHRH is indispensable for the nocturnal augmentation of GH secretion, but that it is unlikely to participate in the genesis of slow-wave sleep. PMID: 15538933
29. GHRH operates as a growth factor in breast cancer and probably other cancers as well PMID: 17372203
30. GHRH enhanced the ghrelin-induced GH secretion but had no effect on cortisol secretion PMID: 18329818
31. Variations in GHRH splice variants may play a role in promoting the development of endometriosis. PMID: 18684444
32. GHRH interacts with ghrelin receptor GHS-R1a, and, in consequence, modifies the ghrelin-associated intracellular signaling pathway PMID: 19088192
33. There is a relationship between allelic variation in the gene encoding GHRH and bone density. PMID: 19487270
34. Our study was conducted on putatively sporadic IGHD patients. Thus, the finding of a dominant mutation with incomplete penetrance is not in contrast with previous reports of a recessive inheritance of GHRHR mutations. PMID: 19622623

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HGNC: 4265

OMIM: 139190

KEGG: hsa:2691

STRING: 9606.ENSP00000237527

UniGene: Hs.37023