Recombinant Human T-box transcription factor TBX21(TBX21)

1. The repression of TBX21 expression by high-affinity binding of YY1 to the -1993C allele may contribute to a decreased development of AIH-1 via suppression of type 1 immunity. PMID: 29358858
2. Phosphorylation of T-bet by RSK2 is required for IFNgamma expression for attenuation of colon cancer metastasis and growth. PMID: 29133416
3. siRNA-mediated knockdown of T-bet and RORgammaT contributes to decreased inflammation in preeclampsia. PMID: 28849203
4. Investigated the associations of IL-28B rs12979860 and TBX21 rs17250932, rs4794067 polymorphisms with the susceptibility to, and outcomes of, hepatitis C virus (HCV) infection; rs4794067 variant genotypes significantly correlated with increased risk of HCV chronic infection and susceptibility PMID: 29399747
5. TBX21 expression level showed a reduction expression in aged men and women. PMID: 28509479
6. Studies indicate the accumulation of T-bet transcription factor (T-bet)+ B cells in autoimmune patients. PMID: 28641866
7. Data show that T-box transcription factor TBX21 (T-bet) expressed in unstimulated memory more than naive B cells, and more in young individuals. PMID: 28457482
8. Studies indicate the induction of T-bet transcription factor (T-bet) in B cells following both HIV and HCV infections. PMID: 28739077
9. Studies indicate that CD11c+ T-bet+ memory B cells exhibit a distinct transcriptome. PMID: 28838763
10. Studies indicate a feedback loop amongst T-bet, STAT and cytokines. PMID: 28923237
11. Studies indicate enriched expression of TBX21 (T-bet), which is important for B cell survival and response to antigen, was observed in CD11c+ B cells. PMID: 28756897
12. the model of mutually antagonistic differentiation programs driven by mutually exclusively expressed T-bet or GATA-3 does not completely explain natural CD4 T cell priming outcomes PMID: 29088218
13. The aim of this study was to investigate the clinical significance of three immune cell-related transcription factors, T-bet, GATA-3 and Bcl-6 in bladder cancer in Tunisian patients. PMID: 27237631
14. this study shows that T-bet restrains IFN-gamma-induced collateral type I IFN circuitry in the Th1 response in vivo PMID: 28623086
15. this review discusses how T-bet regulates transcriptional programs in response to type 1 inflammatory signals PMID: 28279590
16. HDAC11-knockout T cells displayed enhanced proliferation, proinflammatory cytokine production, and effector molecule expression of Eomes and TBX21 transcription factors previously shown to regulate inflammatory cytokine and effector molecule production. PMID: 28550044
17. severe but not euthyroid Hashimoto's thyroiditis is associated with robust upregulation of T-bet and FOXP3 mRNA in peripheral T cells, independent of the thyroid hormone status but proportional to disease activity PMID: 27478306
18. T-helper Cell Type-1 Transcription Factor T-Bet Is Down-regulated in Type 1 Diabetes. PMID: 27917625
19. Results suggest that genetic polymorphisms may predispose individuals to mucosal autoimmune disease through alterations in transcription factor T-bet (TBX21) binding. PMID: 28187197
20. There is a genetic association of ankylosing spondylitis with TBX21 which influences T-bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis. PMID: 27125523
21. this study shows that in peripheral blood, end-stage renal disease patients show increased levels of t-bet PMID: 26970513
22. IFNG and IFNG-TBX21 allele interaction are involved in systemic lupus erythematosus susceptibility in a Chinese Han population. PMID: 26916970
23. expression of T-bet may influence the function of HBV-specific CD8+ T cells and thus can be an attractive target for modulation to improve HBV-specific immunity in CHB. PMID: 26809262
24. HMGB1 contributed to IFN-gamma-producing Th17-cell bias in coronary artery atherosclerosis by controlling expression of T-bet and RUNX3. PMID: 26520896
25. A high copy number of T-bet and GATA-3 confers susceptibility to AAU and AS, and a high copy number of FOXP3 confers susceptibility to female patients with AAU either with or without AS. PMID: 27082299
26. There is a common program of effector T cell differentiation that is regulated by IL-2 and IL-12 signaling and the combined activities of the transcriptional regulators Blimp-1 and T-bet. PMID: 26950239
27. TBX21 expression was low in multiple sclerosis (MS), and stable over time. The low EOMES/TBX21 phenotype in MS reflects cd56+ cell dysregulation. PMID: 26762769
28. Data indicate that overexpression of micrRNA miR-135a alters transcription factor T-bet and GATA binding protein 3 (GATA-3) mRNA expression in allergic rhinitis (AR). PMID: 26418311
29. Our data indicate that Tim-3 expression on NK cells is regulated by T-bet, and that Tim-3 levels correlate with advanced stages of gastric cancer PMID: 26214042
30. T-bet expression might be associated with differentiation into effector memory cells and PD-1 expression in mycobacterial antigen-specific CD4(+) T cells. PMID: 26302932
31. Our results suggested that TBX21 variants may be involved in the etiology of this disease. PMID: 25759111
32. the level of T-bet and Eomesodermin, two T-box transcription factors regulating lymphocyte effector functions, is strongly reduced in NK cells from allogeneic hematopoietic stem cell transplantation recipients compared with healthy control subjects. PMID: 26438526
33. observed the polymorphic allele T was enriched in the chronic periodontitis patients compared to chronic gingivitis patients; investigating the putative functionality TBX21-1993T/C in modulation of local response, observed transcript levels of T-bet, but not of IFN-gamma, were upregulated in homozygote and heterozygote polymorphic subjects PMID: 25832120
34. The tested 25 SNPs in TBX21, GATA3, Rorc and Foxp3 did not associate with BD and VKH syndrome. PMID: 25873156
35. Data show that the expression levels of transcription factors GATA-3 and FOXP3 were upregulated with 1.0 mug/ml galectin-1, while transcription factors TBX21 and RORC expression levels were reduced with both 1.0 and 2.0 mug/ml concentrations of galectin-1. PMID: 25292313
36. Studies indicate that a key feature of age-associated B cells (ABCs) is that they express and depend upon B cell-intrinsic expression of the T-bet transcription factor. PMID: 26297793
37. study concludes that TBX21 gene polymorphism was associated with an increased risk of asthma in Indian population PMID: 25056814
38. The mRNA level of Th1-specific transcription factor T-bet was reduced in patients with liver cancer. PMID: 25552913
39. This study supports the concept that poor human viral-specific CD8(+) T cell functionality is due to an inverse expression balance between T-bet and Eomes PMID: 25032686
40. Polymorphism rs9910408 in TBX21 gene was associated with response to inhaled corticosteroids in asthma. PMID: 24107858
41. Expression of T-bet was high in gammadeltaT cells that were expanded in the Th2 polarizing condition. PMID: 25575062
42. Especially, the ACC, ACT, and ATC haplotypes derived from the TBX21 gene would increase the susceptibility to ESCC in the high-risk Chinese population. PMID: 25577251
43. High tumor nuclei T-bet expression in primary tumors of breast cancer was correlated with poor prognosis and high density of T-bet+ interstitial lymphocytes in primary tumors of breast cancer were correlated with favorable prognosis. PMID: 25400774
44. Knockdown of T-bet expression in Mart-127-35 -specific T-cell-receptor-engineered human CD4(+) CD25(-) and CD8(+) T cells attenuates effector function. PMID: 25495780
45. The transcription factor, t-bet, primes intestinal transplant rejection, and associates with disrupted homeostatic relationships between innate and adaptive immune cells in the allograft mucosa during rejection. PMID: 25340608
46. Results indicate that the pre-existence and nuclear mobilization of transcription factor T-bet in resting memory CD4(+) T cells might be a possible transcriptional mechanism for rapid production of cytokines by memory CD4(+) T cells. PMID: 25378399
47. expression in CD8+ T cells during early chronic infection differentiates controllers from relapsers PMID: 25339676
48. Chronic lymphocytic leukemia cells express CD38 in response to Th1 cell-derived IFN-gamma by a T-bet-dependent mechanism. PMID: 25505279
49. TOX2 plays a crucial role in controlling normal NK cell development by acting upstream of TBX21 transcriptional regulation PMID: 25352127
50. In the presence of 100 ng/ml IL-11, GATA-3 transcript abundance rose up to ~85-fold of that measured in untreated cells, whereas T-bet transcripts were lowered merely to ~41% PMID: 24338248

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HGNC: 11599

OMIM: 208550

KEGG: hsa:30009

STRING: 9606.ENSP00000177694

UniGene: Hs.272409