Recombinant Human Transcription factor AP-2-alpha (TFAP2A)

1. The data suggest that IRF6, TFAP2A, and GRHL3, among others, are shared in neural tube and orofacial development. PMID: 27933721
2. Results show that gout-associated increased NRBP1 expression is regulated through methylation-dependent TFAP2A binding to the B1 region, which might be involved in the pathogenesis of gout. PMID: 28932319
3. our results indicate that AP-2alpha can reverse the Multidrug resistance (MDR) of gastric cancer cells, which may be realized by inhibiting the Notch signaling pathway. PMID: 28439677
4. High-confidence AP2alpha-binding peaks were detected in the regulatory regions of many target genes involved in the development of facial tissues including MSX1, IRF6, TBX22, and MAFB. In addition, we uncovered multiple single-nucleotide polymorphisms (SNPs) disrupting a conserved AP2alpha consensus sequence. PMID: 24641171
5. We identified two SLN genes (PIGR and TFAP2A) that provided high prognostic accuracy in SLN-positive melanoma patients (AUC = 0.864). These two SLN genes, along with clinicopathological features, can differentiate the high- and low-risk groups in node-positive melanoma patients PMID: 27663566
6. We identified miR-1254 as a negative regulator inhibiting HO-1 translation by directly targeting HO-1 3'UTR via its seed region, and suppressing HO-1 transcription via non-seed region-dependent inhibition of transcriptional factor AP-2 alpha (TFAP2A), a transcriptional activator of HO-1. PMID: 28749936
7. dimerization-defective mutant of Nef failed to interact with either CD4 or AP-2 in the BiFC assay, indicating that Nef quaternary structure is required for CD4 and AP-2 recruitment as well as CD4 down-regulation PMID: 28031466
8. Data show that TFAP2A binds many of the same regulatory elements as MITF in melanocytes. PMID: 28249010
9. the atrial fibrillation (AF)-associated SNP rs2595104 altered PITX2c expression via interaction with TFAP2a; such a pathway could ultimately contribute to AF susceptibility at the PITX2 locus associated with AF PMID: 27866707
10. AP-2a is an important transcription factor of DEK expression, which is correlated with the methylation level of the DEK core promoter in hepatocellular carcinoma . PMID: 27499261
11. AP-2alpha expression has a role in human hepatocellular cancer by regulating signaling to affect cell growth and migration PMID: 26780928
12. role in the expression of Latent membrane protein 1 PMID: 26819314
13. Hepatitis B virus X protein is able to elevate the expression of SPHK1 in hepatoma cells by upregulating transcription factor AP2 alpha. PMID: 26073327
14. Results indicate that AP-2alpha activates COX-2 expression to promote NPC growth. PMID: 25669978
15. The AP-2alpha transcription factor may play an important role in suppressing glioma progression. PMID: 25674231
16. TFAP2A might play a role in the development of Ovarian Cancer, and may be a therapeutic target in OC. PMID: 25953442
17. INHA gene expression is upregulated by cAMP via CRE in human trophoblasts, and TFAP2 regulates this expression by interacting with CRE. PMID: 25358080
18. Human melanomas display higher than normal CpG DNA methylation at the TFAP2A promoter.Aberrant CpG DNA methylation as an epigenetic mark associated with TFAP2A silencing in human melanoma. PMID: 25625848
19. ETS1 induction of syncytiotrophoblast marker genes likely results in part from transactivation by activator protein-2alpha. PMID: 25651508
20. Direct sequencing of the coding region of the TFAP2A gene revealed missense mutations in four branchio-oculo-facial syndrome patients; one patient was observed to have a previously described mutation (p.Arg251Gly), while three patients from two families were found to have novel mutations: p.Arg213Ser and p.Val210Asp. PMID: 25590586
21. AP-2alpha continues to be required after lens vesicle separation to maintain a normal lens epithelial cell phenotype and overall lens integrity and to ensure correct fiber cell differentiation. PMID: 24753151
22. Cigarette smoke condensate decreased AP-2alpha expression by suppressing its transcription in human lung cancer cell lines, particularly in p53-deficient NCI-H1299 cells. PMID: 25050743
23. AP2-mediated receptor internalization can be dissociated from AP2-mediated chemotaxis PMID: 24450359
24. During pregnancy, regulation of hCG beta subunit genes expression correlates with both methylation of their promoters and TFAP2A expression level. PMID: 25063728
25. TFAP2A regulates nasopharyngeal carcinoma growth and survival through the modulation of the HIF-1alpha-mediated VEGF/PEDF signaling pathway. PMID: 24335623
26. These data define a mechanism through which AP-2alpha acetylation and increased promoter access induce the expression of the TLR2 gene. PMID: 23680675
27. Hoxa7, Hoxa9 and Hox cofactor Meis1 were identified as AP-2alpha target genes, which are involved in myeloid leukemogenesis. PMID: 23660297
28. The present study examined the expression of AP-2alpha, TIMP-2, MMP-2, MMP-9, and E-cadherin in severe preeclamptic placentas and normal placentas. PMID: 23660954
29. Result suggests that the individual TFAP2A Branchio-Oculo-Facial Syndrome mutations can generate null alleles. These mutations combined with a role for AP-2alpha in epigenetic events, may influence the resultant pathology and the phenotypic variability. PMID: 23578821
30. TFAP2C repressed CD44 expression in basal-derived breast cancer. PMID: 23764310
31. Molecular modeling of the HIV-1 Nef C-terminal flexible loop in complex with AP2 suggests that M168L170 occupies a pocket in the AP2 sigma2 subunit. PMID: 23151229
32. ESDN and AP-2g expression is lower in thick melanomas, it is associated with unfavourable histo-pathological parameters (increased vascularity, vascular invasion and mitoses) and correlates with a shorter DFS like for AP-2a. PMID: 23036739
33. results indicate that Kctd15 acts in the embryo at least in part by specifically binding to the activation domain of AP-2alpha, thereby blocking the function of this critical factor in the neural crest induction hierarchy. PMID: 23382213
34. Evidence of association was obtained with both single marker and haplotype analyses, thus providing a support for TFAP2A in non-syndromic cleft lip with or without cleft palate aetiology PMID: 21781438
35. The different pattern of activator protein-2alpha expression in mild and severe preeclampsia clearly suggests that these conditions may have 2 independent pathogenic mechanisms. PMID: 22575257
36. A mutation in the TFAP2A gene associated with Branchio-Oculo-Facial syndrome (heterozygous H384Y in exon 7) was found in both the proband and her mother. PMID: 22191992
37. a robust transcriptional CTNNAL1 up-regulation occurs during acute ozone-induced stress and is mediated at least in part by ozone-induced recruitments of LEF-1 and AP-2alpha to the human CTNNAL1 promoter. PMID: 22359570
38. fcho1 morphant phenotype is distinct from severe embryonic defects apparent when AP-2 is depleted PMID: 22484487
39. findings suggest that TFAP2A isoforms may be differentially regulated during breast tumourigenesis and this, coupled with differences in their transcriptional activity, may impact on tumour responses to tamoxifen therapy PMID: 21375726
40. AP2 regulates the inhibin alpha subunit gene expression during trophoblast differentiation and may be a key regulator of syncytialization PMID: 21659426
41. Data suggest that AP-2alpha plays an important role in tumor progression and that reduced AP-2alpha expression independently predicts an unfavorable prognosis in gastric adenocarcinoma patients. PMID: 21966377
42. AP-2alpha regulation of CHRNA7 mRNA expression in multiple tissues during development PMID: 21979958
43. Bcl-2 gene transcription is regulated by Ap2alpha-Rb complex binding to the Bcl-2 promoter. PMID: 21850486
44. findings provide a better understanding of the epigenetic mechanisms that are involved in the loss of AP-2alpha protein in prostate cancer cells which lead to decreased cellular zinc uptake-a sine qua non of prostate cancer development PMID: 21940908
45. Patients with Branchio-Oculo-Facial Syndrome (BOFS) and predominant ocular phenotypes can be diagnosed by upper lip examination. TFAP2A analysis provides diagnostic confirmation and improves genetic counselling. PMID: 21728810
46. Data demonstrate a cross-talk between IGF-1R and AT-1R in AT-II and IGF-1-induced Cx43 expression in SV SMCs involving Erk 1/2 and downstream activation of the AP-1 transcription factor. PMID: 20731749
47. A protein-binding microarrays-based study of human healthy and breast tumor tissue extracts allowed the identification of previously unknown AP2alpha target genes. PMID: 21876733
48. These data suggest a novel cellular function of CK-2 as a transcriptional co-activator of AP-2alpha. PMID: 21777522
49. Multiple isoforms of AP-2alpha are highly expressed in pancreatic cancer cell lines including a new isoform, AP-2alpha variant 6, which seems to be pancreatic cancer specific and is deprived of transcriptional activity. PMID: 21654541
50. this study provides further evidence regarding the role of IRF6 variations in non-syndromic cleft lip with or without cleft palate (NSCLP) development and finds no significant association between TFAP2A and NSCLP in this northern Chinese population. PMID: 21683068

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HGNC: 11742

OMIM: 107580

KEGG: hsa:7020

STRING: 9606.ENSP00000368924

UniGene: Hs.519880