Recombinant Mouse Apoptotic protease-activating factor 1 (Apaf1), partial

1. data collectively demonstrated that Apaf1 is a negative regulator of T cell responses and implicated Apaf1 as a potential target for immunosuppressive drug discovery PMID: 29596528
2. miR-183 was induced in protective postconditioning and reduced reperfusion injury of the livers via the targeting of apoptotic signaling. miR-183 mediated the tolerance induced by iPoC in livers via Apaf-1 repressing. PMID: 27580417
3. Apaf1's pivotal role during embryonic development as has been demonstrated to be in regulation of neuronal cell death PMID: 26374523
4. Inhibition of Caspase-9 restricted, while Apaf-1 promoted, Chlamydia pneumoniae infection in HEp-2, HeLa, and mouse epithelial fibroblast (MEF) cells. PMID: 26290316
5. Apaf1 is required for proper cortical neuron differentiation since its deletion specifically impairs axonal outgrowth. PMID: 25975226
6. study demonstrates that MMP-3 leads to caspase-9 activation and suggests that this occurs indirectly via a cytosolic protein, possibly involving Apaf-1 PMID: 25285627
7. results provide evidence that Apaf-1 pharmacological inhibition has therapeutic potential for the treatment of apoptosis-related diseases. PMID: 25330150
8. Study reports experimental evidence suggesting the likely participation of the Apaf1 protein in the aggregation of polyQ stretches; Apaf1 may enhance polyglutamine aggregation by reducing the cellular protein levels of available functional Hsp70 PMID: 24412373
9. miR-23a/b and miR-27a/b are endogenous inhibitory factors of Apaf-1 expression and regulate the sensitivity of neurons to apoptosis. PMID: 24651435
10. a role for Apaf1 at the mitochondria PMID: 24416260
11. The Apaf-1-independent caspase activation was not inhibited by Bcl-2, and occurred without the release of cytochrome c from mitochondria, suggesting that the mitochondrial pathway was not involved in this death process. PMID: 23197294
12. These data are consistent with a model in which alterations of GH signaling and/or insulin sensitivity lead to increased lifespan mediated by decreased renal expression of pro-apoptotic genes. PMID: 21431351
13. we have for the first time demonstrated the critical role of Apaf-1 in the regulation of MAP kinases, rective oxygen species and mitochondrial membrane potential in UVC-radiated fibroblasts. PMID: 22226830
14. plays a pro-survival role by regulating centrosome morphology and function PMID: 21984814
15. Crystal structure of full-length Apaf-1, proper function of Apaf-1 relies on R265 in the vicinity of the bound nucleotide PMID: 21827944
16. Ku70/86 binds to the Apaf1 promoter and represses its activity. PMID: 20966962
17. Findings suggest that Apaf-1/caspase-9-mediated nonapoptotic caspase signaling is required for the proper neural network formation during olfactory development. PMID: 20624980
18. Non-apoptotic cell death of neural progenitor cells may compensate for APAF-1 deficiency in developing central nervous systems. PMID: 19914347
19. A drug targeting Apaf-1 allows protection from apoptosis as well as regeneration in the course of inflammation-induced tissue injury PMID: 19675677
20. Apaf-1 plays a critical role in apoptosis in a subset of tissues and that both E2F1:p53:Apaf-1-dependent and -independent apoptotic pathways operate downstream of Rb. PMID: 11731416
21. The Apaf-1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes PMID: 11859117
22. Apaf1 reduced expression levels generate a mutant phenotype in adult brain and skeleton of mice. PMID: 11859416
23. Apaf-1(-/-) (null) fibroblasts were resistant to cell death initiated by proapoptotic stimuli such as tamoxifen; susceptible to apoptosis induced by thapsigargin and brefeldin-A, both of which induce ER stress PMID: 11919205
24. apoptotic cells show perinuclear cytochrome c aggregation, which may be critical for nuclear redistribution of cytochrome c and Apaf-1. PMID: 12062423
25. Apaf-1 is not involved in positive selection or death by neglect, but may have a partial role in negative selection during early thymic T-cell development. PMID: 12121437
26. Bcl-2 regulates a caspase activation programme independently of the cytochrome c/Apaf-1/caspase-9 'apoptosome', which seems to amplify rather than initiate the caspase cascade PMID: 12374983
27. Apaf-1 has been detected in developing kidney cells and may be required for caspase-9 activation in kidney organogenesis. PMID: 12660414
28. APAF-1 has a nonessential role in apoptosis PMID: 12773531
29. p53 regulation of Apaf-1 expression is tissue-specific PMID: 12883670
30. Apaf-1 and caspase-9 do not suppress c-myc-induced lymphomagenesis and embryo fibroblast transformation. PMID: 14709542
31. Coupling of caspase-9 to Apaf1 in apoptotic pathways is cell-type-specific. PMID: 14713951
32. the cytochrome c-Apaf-1-procaspase-9 complex functions in the caspase amplification rather than in its initiation PMID: 14747474
33. disruption of the Apaf1 gene led to a decrease in apoptosis in the inner ear epithelium, morphogenetic defects and a size reduction of the membranous labyrinth, demonstrating an Apaf1-dependent apoptotic pathway is necessary for inner ear development PMID: 15105372
34. Loss of Apaf-1 or caspase-9 would be unlikely to enhance survival of cancer cells. PMID: 15210730
35. Apaf-1/pro-caspase-9 complex is recruited by Nucling for the induction of stress-induced apoptosis PMID: 15271982
36. Hsp72 inhibits apoptosis upstream of the mitochondria and not through interactions with Apaf-1 PMID: 15371421
37. loss of HAND2 in the pharyngeal arch mesenchyme leads to apoptosis in an Apaf-1-dependent fashion PMID: 15649468
38. These studies indicate the existence of a Cyt c- and apoptosome-independent but Apaf-1-dependent mechanism(s) for caspase activation. PMID: 15907471
39. The data indicate that ultraviolet-C light activates in mouse embryonic fibroblasts both the Fas (CD95, Apo-1) receptor and the mitochondrial damage pathways. PMID: 16215690
40. neuroprotective effects of Hsp70 overexpression in neonatal hypoxic/ischemic injury are mediated by apoptotic pathways through upregulation of FLIP and sequestering Apaf-1, leading to reduced cleavage of caspase-8 and caspase-9 PMID: 16397188
41. progression of UV-induced apoptosis requires IRES-mediated translation of Apaf-1 to ensure continuous levels of Apaf-1 despite an overall suppression of protein synthesis PMID: 16595687
42. Apaf-1 and the mitochondrial pathway of apoptosis play significant roles in ER stress-induced apoptosis. PMID: 16954146
43. These findings identify a critical function of Bax in committing neurons to endoplasmic reticulum stress-induced apoptosis and clarify the importance of the apoptosome as the non-redundant caspase activation pathway. PMID: 17218955
44. Data support a model in which Apaf-1 is necessary for the cleavage or activation of all procaspases and the promotion of mitochondrial apoptotic events induced by genotoxic drugs. PMID: 17348858
45. Caspase 9 activation in response to intrinsic apoptotic stimuli can be uncoupled from Apaf-1 in vivo by XIAP antagonists. PMID: 17562856
46. Apaf-1 and caspase-9 deficiency prevents apoptosis in a Bax-controlled pathway and promotes clonogenic survival during paclitaxel treatment. PMID: 17652622
47. These data point to a role for Apaf-1 as a bona fide tumor suppressor. PMID: 18042457
48. As neurons mature, cytochrome c- mediated apoptosis progresses from inhibitor of apoptosis protein-dependent to -independent regulation because of a complete loss of Apaf-1 expression. PMID: 18056406
49. Survival study of mature postmitotic neuronal populations in mice in which Apaf-1 has been genetically deleted reveals quantitatively normal programmed cell death of developing postmitotic neurons. PMID: 18256270
50. Data show that Faf1 protein level is down-regulated during apoptosis in a caspase-3- and Apaf1-dependent manner. PMID: 18480964

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KEGG: mmu:11783

STRING: 10090.ENSMUSP00000020157

UniGene: Mm.220289