Recombinant Mouse GDNF family receptor alpha-3 (Gfra3)

Code CSB-YP009381MO
MSDS
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Source Yeast
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Code CSB-EP009381MO
MSDS
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Source E.coli
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Code CSB-EP009381MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP009381MO
MSDS
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Source Baculovirus
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Code CSB-MP009381MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Gfra3
Uniprot No.
Alternative Names
Gfra3; GDNF family receptor alpha-3; GDNF receptor alpha-3; GDNFR-alpha-3; GFR-alpha-3
Species
Mus musculus (Mouse)
Expression Region
29-371
Target Protein Sequence
NS LATENRFVNS CTQARKKCEA NPACKAAYQH LGSCTSSLSR PLPLEESAMS ADCLEAAEQL RNSSLIDCRC HRRMKHQATC LDIYWTVHPA RSLGDYELDV SPYEDTVTSK PWKMNLSKLN MLKPDSDLCL KFAMLCTLHD KCDRLRKAYG EACSGIRCQR HLCLAQLRSF FEKAAESHAQ GLLLCPCAPE DAGCGERRRN TIAPSCALPS VTPNCLDLRS FCRADPLCRS RLMDFQTHCH PMDILGTCAT EQSRCLRAYL GLIGTAMTPN FISKVNTTVA LSCTCRGSGN LQDECEQLER SFSQNPCLVE AIAAKMRFHR QLFSQDWADS TFSVVQQQNS N
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Receptor for the glial cell line-derived neurotrophic factor, artemin. Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase.
Gene References into Functions
  1. GFRa3 is expressed at the surface of a subset of Ngn3-positive endocrine progenitors as well as of embryonic alpha- and beta-cells in the mouse pancreas. PMID: 26576643
  2. cold allodynia is mediated exclusively by a single molecular pathway, suggesting that artemin-GFRalpha3 signaling can be targeted to selectively treat cold pain. PMID: 27051069
  3. Suggest that enhanced GFRalpha3 signaling in visceral afferents may contribute to development of colorectal hypersensitivity. PMID: 21193524
  4. GFRalpha3, the receptor for artemin, is increased following axotomy and regeneration in heat-sensitive C-fibers. PMID: 21123573
Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Protein Families
GDNFR family
Database Links
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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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