Recombinant Mouse Low-density lipoprotein receptor(Ldlr),partial

Code CSB-YP012846MO
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Source Yeast
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Code CSB-EP012846MO
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Source E.coli
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Code CSB-EP012846MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP012846MO
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Source Baculovirus
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Code CSB-MP012846MO
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Source Mammalian cell
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Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Ldlr; Low-density lipoprotein receptor; LDL receptor
Mus musculus (Mouse)
Protein Length
Tag Info
The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

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Target Background

Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
Gene References into Functions
  1. Vitamin D3 was a significantly beneficial dietary additive to blunt a prediabetic phenotype in diet-induced obesity of female LDLR(-/-) and LDLR(+/+) mice. PMID: 28474500
  2. The results obtained from liver-specific NPC1L1 transgenic mouse (L1-Tg) crossed with LDLR-/- mouse indicated no feedback mechanism to inhibit NPC1L1 function in liver and hepatic expression of NPC1L1 correlated with VLDL secretion in hypercholesterolemia state. PMID: 29601818
  3. Type 2 diabetic, hyperlipidemic LDLr(-/-)ApoB(100/100) mice show increased calcific aortic valve disease. PMID: 29539583
  4. Platelet activation in ApoE and LDLR-deficient mice was not further increased by strenuous exercise, but was instead attenuated. PMID: 28067100
  5. Our data suggests that sphingosine-1-phosphate receptor 1 in macrophages plays an important role in protecting them against apoptosis in vitro and in atherosclerotic plaques in vivo, and delays diet induced atherosclerosis development in Ldlr deficient mice PMID: 29244772
  6. Macrophage Fatp1 limits atherogenesis in LDL receptor knockout mice. PMID: 29035781
  7. Network analysis reveals DJ-1/LDLR as common host proteins modulating pathogenesis of neurotropic viruses. PMID: 27581498
  8. Atorvastatin therapy did not show cholesterol-independent effects on inflammation in atherosclerotic lesions in Ldlr(-/-)Apob(100/100) mice, whereas a cholesterol-lowering diet intervention was effective. PMID: 28457625
  9. LDLR modulation is associated with early atherosclerosis-related lymphatic dysfunction, and bring forth a pleiotropic role for PCSK9 in lymphatic function. PMID: 27279328
  10. FXR signaling is a bile acid nuclear receptor that regulates lipids and glucose homeostasis and lack of it causes hepatomegaly and liver dysfunction. PMID: 29142166
  11. Endothelial LOX-1 overexpression in an atherosclerosis-prone LDL receptor knockout mice impairs endothelial function, proving its importance in the development of atherosclerosis. PMID: 29096854
  12. Dietary supplementation with the long chain monounsaturated fatty acid isomers C20:1 or C22:1 was equally effective in reducing atherosclerosis in LDLr(-/-)mice and this may partly occur through activation of the Ppar signaling pathways and favorable alterations in the proteome of lipoproteins. PMID: 28486149
  13. Dihydromyricetin could reduce atherosclerosis via its pleiotropic effects, including improvement of endothelial dysfunction, inhibition of macrophage foam cell formation, amelioration of lipid profiles, anti-inflammatory action and anti-oxidative effect in LDL receptor deficient mice. PMID: 28500865
  14. data reveal a novel role of Ldlr as functional modulator of metabolic alterations associated with hypogonadism. PMID: 24837748
  15. this work identifies a novel posttranscriptional regulatory mechanism by which dietary cholesterol inhibits liver LDLR expression via inducing HNRNPD to accelerate LDLR mRNA degradation. PMID: 24792925
  16. PPARdelta activation attenuates hepatic steatosis in Ldlr-/- mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity. PMID: 24864274
  17. both LRP1 and LDLR expression and agLDL uptake are regulated by P2Y2R in vascular smooth muscle cells, and agLDL uptake due to P2Y2R activation is dependent upon cytoskeletal reorganization mediated by P2Y2R binding to FLN-A PMID: 27522265
  18. Results indicate the importance of the LDL receptor (LDLR) in the growth of triple-negative and HER2-overexpressing breast cancers in the setting of elevated circulating LDL cholesterol (LDL-C). PMID: 28759039
  19. this study shows that STAT4 regulates the CD8(+) regulatory T cell/T follicular helper cell axis and promotes atherogenesis in insulin-resistant Ldlr(-/-) mice PMID: 29055004
  20. Data (including data from studies using transgenic mice) suggest that plasma and liver cholesterol homeostasis and hepatic expression of LDL receptor and lipolysis-stimulated lipoprotein receptor are modulated differently and independently by APOE allele (E4 versus E3) and docosahexaenoic acid intake. (APOE = apolipoprotein E) PMID: 27239755
  21. increased blood pressure and reduced aortic compliance are not direct causes of increased aortic plaque accumulation in a model of LDLR knockout mice PMID: 27062406
  22. Cdkn2a transcripts modulate platelet production and activity in the setting of hypercholesterolemic LDLR knockout mice. PMID: 27098250
  23. Lysosomal oxLDL accumulation within macrophages contributes to murine atherosclerosis. Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr(-/-) mice PMID: 27816810
  24. This study investigated the effects of Aerobic exercise training on endothelial dysfunction and vascular redox status in the aortas of LDL receptor knockout mice (LDLr(-/-)), a genetic model of familial hypercholesterolemia. PMID: 27435231
  25. PCSK9 inhibits lipoprotein(a) clearance through the LDLR. PMID: 28750079
  26. PTP1B inhibitors protect against atherosclerotic plaque formation in the LDLR(-/-) mouse model of atherosclerosis. PMID: 28899902
  27. LDLR is a relevant receptor for CNS drug delivery via receptor-mediated transcytosis and that the peptide vectors we developed have the potential to transport drugs PMID: 28108572
  28. ApoC-III inhibits turnover of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR/LRP1 axis PMID: 27400128
  29. Leukocyte GPR120/FFAR4 WT or KO mice in the LDL receptor KO background were generated by bone marrow transplantation.leukocyte GPR120 expression has minimal effects on dietary PUFA-induced plasma lipid/lipoprotein reduction and atheroprotection, and there is no distinction between n-3 versus n-6 PUFAs in activating anti-inflammatory effects of leukocyte GPR120/FFAR4 in vivo PMID: 27811230
  30. This study reports the creation of a mouse model of autoimmunity-associated atherosclerosis by transplanting bone marrow from FcgammaRIIB knockout (FcRIIB(-/-)) mice into LDL receptor knockout mice. PMID: 26891734
  31. hepatocytes clear lipopolysaccharides from the circulation via the LDLR. PMID: 27171436
  32. Atherosclerosis and Hypercholesterolemia in Mice Lacking Both the Melanocortin Type 4 Receptor and Low Density Lipoprotein Receptor PMID: 28030540
  33. Cyclosporin A does not cause hyperlipidemia via direct effects on the LDLr. Rather, LDLr deficiency plays an important permissive role for CsA-induced hyperlipidemia, which is associated with abnormal lipoprotein clearance, decreased lipoprotein lipase activity, and increased levels of apolipoprotein C-III and proprotein convertase subtilisin/kexin type 9. PMID: 27150391
  34. Ldlr(-/-) Creb3l3(-/-) mice developed significantly more atherosclerotic lesions in the aortas than Ldlr(-/-) mice. PMID: 27417587
  35. Loss of Jnk1, but not Jnk2, in macrophages protects them from apoptosis, increasing cell survival, and this accelerates early atherosclerosis in LDL receptor knockout mice. PMID: 27102962
  36. ATP-citrate lyase inhibitor bempedoic acid effectively prevents plasma and tissue lipid elevations and attenuates the onset of inflammation, leading to the prevention of atherosclerotic lesion development in a Ldlr knockout mouse model of metabolic dysregulation. PMID: 28153881
  37. Increased colonization of the disease-protective gut bacteria Akkermansia muciniphila protected the host from acute and chronic hyperlipidemia by enhancing the low-density lipoprotein receptor expression and alleviating hepatic endoplasmic reticulum stress and the inflammatory response in CREBH-null mice. PMID: 27230129
  38. These data indicate that serum amyloid A (SAA)regulates the level of bone marrow monocytes and their myeloid progenitors in hyperlipidemic Ldlr(-/-) mice. PMID: 27339627
  39. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation. PMID: 27284008
  40. Ldlr knockout mice had smaller litter sizes than wild type. KO mice had higher serum cholesterol level, and decreased cholesterol, triglycerides and total lipids in ovary. KO mice had fewer ovarian follicles, lower estrogen levels and impaired estrous cycles and ovulation than wild type mice. PMID: 25023761
  41. These data strongly imply that LDLr significantly contributes to beta-carotene uptake in the adult mouse liver. In contrast, LDLr does not seem to mediate acquisition of beta-carotene by the placental-fetal unit. PMID: 27916814
  42. The values in the Apoe-deficient mice were much greater than in the Ldlr mice. These findings suggest that Apoe-deficient mice showed increased susceptibility to inflammation-associated colorectal carcinogenesis due to their high reactivity to inflammatory stimuli. PMID: 27801847
  43. We carried out our experiment in mice deficient in the low density lipoprotein (LDL) receptor and expressing only ApoB100 molecule (ApoB-LDLr) where the development of atherosclerosis is known to closely mimic human atherosclerosis PMID: 27133569
  44. Atherosclerosis is accelerated in LDL receptor-deficient mice fed a high-fat diet. PMID: 26974699
  45. Myeloid cell IFNGR2 deficiency does not affect atherosclerosis development in LDLR knockout mice. PMID: 26828750
  46. HDL is redundant for adrenal steroidogenesis in LDLR knockout mice with a human-like lipoprotein profile PMID: 26891738
  47. Neurometabolic roles of ApoE and Ldl-R in mouse brain. PMID: 26686234
  48. Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model. PMID: 26619823
  49. Suggest Idol as a gatekeeper of LDLR-dependent ApoE and Abeta clearance in the brain and a potential enzyme target for therapeutic intervention in Alzheimer disease. PMID: 26582899
  50. binding of PCSK9 to GRP94 protects LDLR from degradation likely by preventing early binding of PCSK9 to LDLR PMID: 26628375

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Subcellular Location
Cell membrane; Single-pass type I membrane protein. Membrane, clathrin-coated pit. Golgi apparatus. Early endosome. Late endosome. Lysosome.
Protein Families
LDLR family
Database Links
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