Mouse low density lipoprotein receptor,LDLR ELISA Kit

Code CSB-EL012846MO
Size 96T
See More Details 24T ELISA kits trial application
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Product Details

Target Name low density lipoprotein receptor
Alternative Names Ldlr ELISA Kit; Low-density lipoprotein receptor ELISA Kit; LDL receptor ELISA Kit
Abbreviation LDLR
Uniprot No. P35951
Species Mus musculus (Mouse)
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Storage Store at 2-8°C. Please refer to protocol.

Target Data

Function Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.
Gene References into Functions
  1. Vitamin D3 was a significantly beneficial dietary additive to blunt a prediabetic phenotype in diet-induced obesity of female LDLR(-/-) and LDLR(+/+) mice. PMID: 28474500
  2. The results obtained from liver-specific NPC1L1 transgenic mouse (L1-Tg) crossed with LDLR-/- mouse indicated no feedback mechanism to inhibit NPC1L1 function in liver and hepatic expression of NPC1L1 correlated with VLDL secretion in hypercholesterolemia state. PMID: 29601818
  3. Type 2 diabetic, hyperlipidemic LDLr(-/-)ApoB(100/100) mice show increased calcific aortic valve disease. PMID: 29539583
  4. Platelet activation in ApoE and LDLR-deficient mice was not further increased by strenuous exercise, but was instead attenuated. PMID: 28067100
  5. Our data suggests that sphingosine-1-phosphate receptor 1 in macrophages plays an important role in protecting them against apoptosis in vitro and in atherosclerotic plaques in vivo, and delays diet induced atherosclerosis development in Ldlr deficient mice PMID: 29244772
  6. Macrophage Fatp1 limits atherogenesis in LDL receptor knockout mice. PMID: 29035781
  7. Network analysis reveals DJ-1/LDLR as common host proteins modulating pathogenesis of neurotropic viruses. PMID: 27581498
  8. Atorvastatin therapy did not show cholesterol-independent effects on inflammation in atherosclerotic lesions in Ldlr(-/-)Apob(100/100) mice, whereas a cholesterol-lowering diet intervention was effective. PMID: 28457625
  9. LDLR modulation is associated with early atherosclerosis-related lymphatic dysfunction, and bring forth a pleiotropic role for PCSK9 in lymphatic function. PMID: 27279328
  10. FXR signaling is a bile acid nuclear receptor that regulates lipids and glucose homeostasis and lack of it causes hepatomegaly and liver dysfunction. PMID: 29142166
  11. Endothelial LOX-1 overexpression in an atherosclerosis-prone LDL receptor knockout mice impairs endothelial function, proving its importance in the development of atherosclerosis. PMID: 29096854
  12. Dietary supplementation with the long chain monounsaturated fatty acid isomers C20:1 or C22:1 was equally effective in reducing atherosclerosis in LDLr(-/-)mice and this may partly occur through activation of the Ppar signaling pathways and favorable alterations in the proteome of lipoproteins. PMID: 28486149
  13. Dihydromyricetin could reduce atherosclerosis via its pleiotropic effects, including improvement of endothelial dysfunction, inhibition of macrophage foam cell formation, amelioration of lipid profiles, anti-inflammatory action and anti-oxidative effect in LDL receptor deficient mice. PMID: 28500865
  14. data reveal a novel role of Ldlr as functional modulator of metabolic alterations associated with hypogonadism. PMID: 24837748
  15. this work identifies a novel posttranscriptional regulatory mechanism by which dietary cholesterol inhibits liver LDLR expression via inducing HNRNPD to accelerate LDLR mRNA degradation. PMID: 24792925
  16. PPARdelta activation attenuates hepatic steatosis in Ldlr-/- mice by enhanced fat oxidation, reduced lipogenesis, and improved insulin sensitivity. PMID: 24864274
  17. both LRP1 and LDLR expression and agLDL uptake are regulated by P2Y2R in vascular smooth muscle cells, and agLDL uptake due to P2Y2R activation is dependent upon cytoskeletal reorganization mediated by P2Y2R binding to FLN-A PMID: 27522265
  18. Results indicate the importance of the LDL receptor (LDLR) in the growth of triple-negative and HER2-overexpressing breast cancers in the setting of elevated circulating LDL cholesterol (LDL-C). PMID: 28759039
  19. this study shows that STAT4 regulates the CD8(+) regulatory T cell/T follicular helper cell axis and promotes atherogenesis in insulin-resistant Ldlr(-/-) mice PMID: 29055004
  20. Data (including data from studies using transgenic mice) suggest that plasma and liver cholesterol homeostasis and hepatic expression of LDL receptor and lipolysis-stimulated lipoprotein receptor are modulated differently and independently by APOE allele (E4 versus E3) and docosahexaenoic acid intake. (APOE = apolipoprotein E) PMID: 27239755
  21. increased blood pressure and reduced aortic compliance are not direct causes of increased aortic plaque accumulation in a model of LDLR knockout mice PMID: 27062406
  22. Cdkn2a transcripts modulate platelet production and activity in the setting of hypercholesterolemic LDLR knockout mice. PMID: 27098250
  23. Lysosomal oxLDL accumulation within macrophages contributes to murine atherosclerosis. Prevention of oxLDL uptake leads to decreased atherosclerosis in hematopoietic NPC1-deficient Ldlr(-/-) mice PMID: 27816810
  24. This study investigated the effects of Aerobic exercise training on endothelial dysfunction and vascular redox status in the aortas of LDL receptor knockout mice (LDLr(-/-)), a genetic model of familial hypercholesterolemia. PMID: 27435231
  25. PCSK9 inhibits lipoprotein(a) clearance through the LDLR. PMID: 28750079
  26. PTP1B inhibitors protect against atherosclerotic plaque formation in the LDLR(-/-) mouse model of atherosclerosis. PMID: 28899902
  27. LDLR is a relevant receptor for CNS drug delivery via receptor-mediated transcytosis and that the peptide vectors we developed have the potential to transport drugs PMID: 28108572
  28. ApoC-III inhibits turnover of TG-rich lipoproteins primarily through a hepatic clearance mechanism mediated by the LDLR/LRP1 axis PMID: 27400128
  29. Leukocyte GPR120/FFAR4 WT or KO mice in the LDL receptor KO background were generated by bone marrow transplantation.leukocyte GPR120 expression has minimal effects on dietary PUFA-induced plasma lipid/lipoprotein reduction and atheroprotection, and there is no distinction between n-3 versus n-6 PUFAs in activating anti-inflammatory effects of leukocyte GPR120/FFAR4 in vivo PMID: 27811230
  30. This study reports the creation of a mouse model of autoimmunity-associated atherosclerosis by transplanting bone marrow from FcgammaRIIB knockout (FcRIIB(-/-)) mice into LDL receptor knockout mice. PMID: 26891734
  31. hepatocytes clear lipopolysaccharides from the circulation via the LDLR. PMID: 27171436
  32. Atherosclerosis and Hypercholesterolemia in Mice Lacking Both the Melanocortin Type 4 Receptor and Low Density Lipoprotein Receptor PMID: 28030540
  33. Cyclosporin A does not cause hyperlipidemia via direct effects on the LDLr. Rather, LDLr deficiency plays an important permissive role for CsA-induced hyperlipidemia, which is associated with abnormal lipoprotein clearance, decreased lipoprotein lipase activity, and increased levels of apolipoprotein C-III and proprotein convertase subtilisin/kexin type 9. PMID: 27150391
  34. Ldlr(-/-) Creb3l3(-/-) mice developed significantly more atherosclerotic lesions in the aortas than Ldlr(-/-) mice. PMID: 27417587
  35. Loss of Jnk1, but not Jnk2, in macrophages protects them from apoptosis, increasing cell survival, and this accelerates early atherosclerosis in LDL receptor knockout mice. PMID: 27102962
  36. ATP-citrate lyase inhibitor bempedoic acid effectively prevents plasma and tissue lipid elevations and attenuates the onset of inflammation, leading to the prevention of atherosclerotic lesion development in a Ldlr knockout mouse model of metabolic dysregulation. PMID: 28153881
  37. Increased colonization of the disease-protective gut bacteria Akkermansia muciniphila protected the host from acute and chronic hyperlipidemia by enhancing the low-density lipoprotein receptor expression and alleviating hepatic endoplasmic reticulum stress and the inflammatory response in CREBH-null mice. PMID: 27230129
  38. These data indicate that serum amyloid A (SAA)regulates the level of bone marrow monocytes and their myeloid progenitors in hyperlipidemic Ldlr(-/-) mice. PMID: 27339627
  39. Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Single Domain Antibodies Are Potent Inhibitors of Low Density Lipoprotein Receptor Degradation. PMID: 27284008
  40. Ldlr knockout mice had smaller litter sizes than wild type. KO mice had higher serum cholesterol level, and decreased cholesterol, triglycerides and total lipids in ovary. KO mice had fewer ovarian follicles, lower estrogen levels and impaired estrous cycles and ovulation than wild type mice. PMID: 25023761
  41. These data strongly imply that LDLr significantly contributes to beta-carotene uptake in the adult mouse liver. In contrast, LDLr does not seem to mediate acquisition of beta-carotene by the placental-fetal unit. PMID: 27916814
  42. The values in the Apoe-deficient mice were much greater than in the Ldlr mice. These findings suggest that Apoe-deficient mice showed increased susceptibility to inflammation-associated colorectal carcinogenesis due to their high reactivity to inflammatory stimuli. PMID: 27801847
  43. We carried out our experiment in mice deficient in the low density lipoprotein (LDL) receptor and expressing only ApoB100 molecule (ApoB-LDLr) where the development of atherosclerosis is known to closely mimic human atherosclerosis PMID: 27133569
  44. Atherosclerosis is accelerated in LDL receptor-deficient mice fed a high-fat diet. PMID: 26974699
  45. Myeloid cell IFNGR2 deficiency does not affect atherosclerosis development in LDLR knockout mice. PMID: 26828750
  46. HDL is redundant for adrenal steroidogenesis in LDLR knockout mice with a human-like lipoprotein profile PMID: 26891738
  47. Neurometabolic roles of ApoE and Ldl-R in mouse brain. PMID: 26686234
  48. Absence of Elovl6 attenuates steatohepatitis but promotes gallstone formation in a lithogenic diet-fed Ldlr(-/-) mouse model. PMID: 26619823
  49. Suggest Idol as a gatekeeper of LDLR-dependent ApoE and Abeta clearance in the brain and a potential enzyme target for therapeutic intervention in Alzheimer disease. PMID: 26582899
  50. binding of PCSK9 to GRP94 protects LDLR from degradation likely by preventing early binding of PCSK9 to LDLR PMID: 26628375
  51. Short-term modulation of miR-27b expression in wild-type mice regulates hepatic LDLR and ABCA1 expression but does not influence plasma and hepatic lipid levels. PMID: 26520906
  52. miR-185 controls cholesterol homeostasis as a key posttranscriptional LDLR modulator in hepatic cells, providing novel insight into the regulatory mechanism for LDLR expression and the anti-atherosclerosis effect of miR-185-inhibitor. PMID: 26523989
  53. The absence of PCSK9 results in a sex- and tissue-specific subcellular distribution of the LDLR and VLDLR, which is determined by estradiol levels. PMID: 26323289
  54. In the present study, we examined the effects of H2 on atherosclerotic plaque stability and the underlying mechanisms in low-density lipoprotein receptor-knockout (LDLR-/-) mice and macrophage-derived foam cell models. PMID: 26117323
  55. Targeted deletion of ChREBP in bone marrow cells resulted in accelerated atherosclerosis progression in Ldlr-/- mice with increased monocytosis, lesional macrophage accumulation, and plaque necrosis. PMID: 26411684
  56. Blockade of Tim-1 and Tim-4 enhances atherosclerosis in LDL receptor knockout mice. PMID: 26821944
  57. Reveal a previously unappreciated strong link between adipose tissue and LDLR in plasma cholesterol metabolism in LDLR knockout mice. PMID: 26921684
  58. The effect of hypercholesterolemia induced immune response and inflammation on progression of atherosclerosis in ApoB(tm25gy) LDLr(tm1Her) mice, expressing only ApoB100 and deficient in the low density lipoprotein receptor. PMID: 26178198
  59. The Liver Clock Controls Cholesterol Homeostasis through Trib1 Protein-mediated Regulation of PCSK9/Low Density Lipoprotein Receptor (LDLR) Axis. PMID: 26547624
  60. SAA1/2 produced by macrophages promotes early lesion formation in the ascending aorta in LDLR knockout mice. PMID: 26187995
  61. to examine potential mechanisms by which murine norovirus influences the atherosclerosis disease process, we fed Ldlr(-/-) mice an atherogenic diet PMID: 25926396
  62. Fibronectin extra domain A stabilises atherosclerotic plaques in apolipoprotein E and in LDL-receptor-deficient mice. PMID: 25881051
  63. Porphyromonas gingivalis infection in the oral cavity can lead to significant TLR2-CD36/SR-B2 dependent IL1ss release. PMID: 25938460
  64. Increasing Grx2a activity in macrophage mitochondria disrupts mitochondrial respiration and ATP production, but without affecting the proatherogenic potential of macrophages from LDL receptor knockout mice. PMID: 25966442
  65. DPP4 inhibiton appeared to suppress neointimal formation by inhibiting inflammation, independently of its effects on glucose or cholesterol metabolism in atherogenic LDL receptor KO mice. PMID: 25770025
  66. Replenishment of deleted LDLR by adenovirus-mediated gene delivery results in alleviation of atherosclerosis in diabetic mice. PMID: 26046657
  67. Endothelial dysfunction in LDLR(-/-) mice fed a high fat diet could not be improved by voluntary running. PMID: 25936306
  68. Prolonged lowering of plasma S1P, using sphingosine kinase inhibitor, produces pro-atherogenic effects in LDL-R-/- mice that are evident under condition of pronounced hypercholesterolemia. PMID: 25801013
  69. Haloperidol treatment lowered the susceptibility of hyperlipidaemic LDL receptor knockout mice to develop atherosclerotic lesions by inhibiting macrophage chemotaxis. PMID: 25572138
  70. hepatic insulin resistance is unrelated to cholesterol-induced hepatic inflammation in Ldlr (-/-) mice, indicating that hepatic inflammation may not contribute to metabolic dysfunction per se PMID: 25815343
  71. our studies in a mouse model with a human-like lipoprotein profile provide the first in vivo evidence for a novel inhibitory role of the LDLR in the control of adrenal glucocorticoid production. PMID: 26136384
  72. LDLR expression has a substantial impact on both HDL and LDL metabolism in mice. PMID: 24954421
  73. both LDLR and ApoE are required for PCSK9 inhibitor-mediated reductions in atherosclerosis PMID: 25258384
  74. the impact of macrophage Akt1 and Akt2 on early atherosclerosis PMID: 25240046
  75. GSK3alpha plays a pro-atherogenic role, possibly by mediating the effects of endoplasmic reticulum stress in the activation of pro-atherogenic pathways in high fat diet-fed low density lipoprotein receptor-deficient mice PMID: 25451156
  76. LDLR deficiency contributes to impaired spatial cognition in mice. PMID: 25413784
  77. the serum levels of ox-HDL peaked early before the formation of lesions in LDLR knockouts fed with a high fat diet similar to oxidatized low density lipoprotein PMID: 25912129
  78. MiR-143/145 deficiency has a role in attenuating the progression of atherosclerosis in Ldlr-/-mice PMID: 25008143
  79. LDL receptor and ApoE have roles in the clearance of ApoM-associated sphingosine 1-phosphate PMID: 25505264
  80. MMP-2 overexpression may protect the LDLR from PCSK-9-induced degradation. PMID: 25613181
  81. nucleotide catabolism in aortoiliac bifurcation of atherosclerotic ApoE/LDLr double knock out mice PMID: 24940687
  82. Study shows that the lack of LDLr increases the susceptibility to Abeta-induced neurotoxicity in mice providing new evidence about the crosslink between familial hypercholesterolemia and cognitive impairment PMID: 24577472
  83. Pla2g1b inactivation suppressed diet-induced body weight gain and reduced diabetes and atherosclerosis in LDL receptor-deficient mice. PMID: 24747111
  84. Replacement of saturated fatty acids by n-3 FA effectively reduce arterial lipid deposition by decreasing aortic LpL, macrophages and pro-inflammatory markers in LDLR-/- mice. PMID: 24747115
  85. the effect of high-fat/cholesterol/cholate diet, LDLR gene deficiency, and the diet-genotype interaction caused a significant perturbation in choline metabolism, notably the choline oxidation pathway. PMID: 20197419
  86. Thalidomide prevented neovascularization and atherogenesis in the aortas of ApoE/LDLR double knockout mice. PMID: 24487918
  87. Results demonstrate that the apoE-LDLR interaction affects regional brain apoE levels, brain cholesterol, and cognitive function in an apoE isoform-dependent manner PMID: 24412220
  88. Akt2/LDLr dKO mice develop insulin resistance and complex atherosclerotic lesions. PMID: 24220638
  89. LDLR-knockout mice fed a high-fat high-sucrose diet proved to be a time-saving model for cardio-metabolic disease. PMID: 24438079
  90. A vicious cycle in LDLR degradation might be generated by PCSK9 induced by hepatic Idol overexpression via dual mechanisms: sterol regulatory element-binding protein 2/LDLR. PMID: 24675665
  91. IDE deficiency in bone marrow-derived cells results in larger atherosclerotic lesions, increased lesion-associated Abeta and RAGE, and higher serum cholesterol in male, Ldlr(-/-) mice. PMID: 23684818
  92. We have demonstrated enhanced vascular calcification in LDL receptor knockout (LDLR(-/-)) mice fed a diet low in vitamin D. PMID: 24647396
  93. Ldlr deficiency is associated with significant changes in the hepatic lipidome that affect cytokine-growth factor signaling and impair liver regeneration. PMID: 23712050
  94. Data indicate that the single-chain antibodies downregulated the expression of Cd36, Tlr-4 and Cox-2 in macrophages and decreased the atherosclerotic lesion area in Ldlr(-/-) mice. PMID: 23924793
  95. Identify hematopoietic cell Rev-erbalpha as a new modulator of atherogenesis in LDL receptor knockout mice. PMID: 23963755
  96. HDL cholesteryl ester uptake was impaired in Ldlr (-/-) Scarb1 (I179N) mice compared to Ldlr (-/-) control mice PMID: 23722970
  97. LDLR and APOE are important factors for PCSK9-mediated HDL regulation PMID: 23883163
  98. myostatin directly up-regulated lipogenic genes and increased fat accumulation in cultured liver cells PMID: 23936482
  99. Anti-inflammatory effects of LXR activators are of key importance to their antiatherosclerotic effects in Ldlr knockout mice independent of cholesterol efflux pathways mediated by macrophage ABCA1/G1. PMID: 24311381
  100. Low-density lipoprotein receptor (LDLR) is the main route of elimination of proprotein convertase subtilisin/kexin type 9 (PCSK9) and reciprocal regulation between these 2 proteins controls serum PCSK9 levels, hepatic LDLR expression, and serum LDL level. PMID: 23690465

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Subcellular Location Cell membrane, Single-pass type I membrane protein, Membrane, clathrin-coated pit, Golgi apparatus, Early endosome, Late endosome, Lysosome
Protein Families LDLR family
Database Links

KEGG: mmu:16835

STRING: 10090.ENSMUSP00000034713

UniGene: Mm.3213

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