Recombinant Mouse Metabotropic glutamate receptor 1 (Grm1), partial

Code CSB-YP009931MO
Size Pls inquire
Source Yeast
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP009931MO
Size Pls inquire
Source E.coli
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-EP009931MO-B
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-BP009931MO
Size Pls inquire
Source Baculovirus
Have Questions? Leave a Message or Start an on-line Chat
Code CSB-MP009931MO
Size Pls inquire
Source Mammalian cell
Have Questions? Leave a Message or Start an on-line Chat

Product Details

>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
Grm1; Gprc1a; Mglur1Metabotropic glutamate receptor 1; mGluR1
Mus musculus (Mouse)
Protein Length
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Please contact us to get it.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum (By. similarity). May function in the light response in the retina.
Gene References into Functions
  1. Study states that metabotropic glutamate receptor subtype 1 (mGluR1) is critical for elimination of surplus climbing fiber-Purkinje cell synapses in the cerebellum, retinogeniculate synapses require mGluR1 for maintenance of mature connectivity. PMID: 28711710
  2. Study shows that blocking of metabotropic glutamate type 5 receptor (mGlu5) reduced the dysregulation of glutamate transmission and improved motor coordination in the metabotropic glutamate type 1 receptor (Grm1crv4) mouse model of cerebellar ataxia SCAR13. PMID: 28982591
  3. These findings demonstrate that mGlu1 receptors play a key role in excitotoxic degeneration of retinal ganglion cell PMID: 28918254
  4. this work reveals novel functions of mGlu1 receptors in the bone and indicates that in osteoblasts mGlu1 receptors are necessary for production of normal bone matrix, longitudinal bone growth, and normal skeletal development. PMID: 27989650
  5. mGluR1 activation at the onset of reperfusion induces cardioprotection and might represent a putative strategy to prevent ischaemia-reperfusion injury. PMID: 28453728
  6. These findings demonstrate a deleterious positive feedback loop involving elevated intracellular calcium and enhanced mGluR1 function, a mechanism likely to contribute to Purkinje neuron dysfunction and loss in spinocerebellar ataxia type 2. PMID: 28518055
  7. mouse external globus pallidus astrocytes critically control ambient glutamate level, which in turn gates striatopallidal transmission via the activation of presynaptic metabotropic glutamate receptors. PMID: 27880915
  8. The results of our study showed that thalamic mGluR1-PLCbeta4 pathway was critical in controlling sleep architecture. PMID: 27998287
  9. This study confirmed the presence of mGluR1/5 complex by (i) reverse immunoprecipitation using an mGluR1 antibody to pulldown mGluR5 from hippocampal tissue. PMID: 27392515
  10. results demonstrate that mGluR1 is crucial for the visual-experience-dependent maintenance of mature synaptic connectivity in the dorsal Lateral Geniculate Nuc. PMID: 27545713
  11. These results suggest that impairment of synaptic mGluR cascades is one of the important contributing factors to cerebellar ataxia in early and middle stages of spinocerebellar ataxia type 1 (SCA1) pathology, and that modulation of mGluR signalling by baclofen or other clinical interventions may be therapeutic targets to treat SCA1 PMID: 27440721
  12. activation of mGluR1 expressed by OCCM-30 cells induces cell proliferation in a manner that is dependent on mitogen-activated protein kinase pathways. PMID: 27261070
  13. In a mouse model of human spino-cerebellar ataxia type 1 (early SCA1, 12 weeks) we find prolonged parallel fiber mGluR1-dependent synaptic currents and calcium signaling PMID: 27147646
  14. Here we identify mGluR1 and mGluR5 as key elements in the dynamic regulation of cholinergic synaptic inputs onto neurons of the TRN. Our findings highlight potential mechanisms that regulate cholinergic signaling in the mammalian brain. PMID: 27466334
  15. data suggest that Lys(63)-linked polyubiquitination is involved in the ligand-mediated endocytosis of mGluR1. PMID: 28011638
  16. This study provides evidence that ASIC1a is involved in group I metabotropic glutamate (mGlu) receptor-induced increase in action potential firing. PMID: 28137639
  17. Homodimerization enhances both sensitivity and dynamic range of the ligand-binding domain of type 1 metabotropic glutamate receptor PMID: 27800613
  18. Unpredictable chronic mild stress mice exhibited elevated nucleus accumbens (NAC) shell levels of mGlu1alpha. The expression of stress-alcohol locomotor cross-sensitization was associated with lower mGlu1alpha within the NAC core. PMID: 25916683
  19. Ionizing radiation is able to trigger the altered neuronal differentiation in undifferentiated neural stem-like cells through PI3K-STAT3-mGluR1 and PI3K-p53 signaling. PMID: 26828720
  20. Because the mGluR1-PKCgamma signaling pathway is essential for the late-phase of climbing fiber synapse elimination, this signaling pathway promotes the two key features of excitatory synaptic wiring in Purkinje cells. PMID: 26858447
  21. Numb is a regulator for constitutive expression and dynamic transport of mGlu1. PMID: 26621723
  22. STIM1 is a key regulator of mGluR1-dependent Ca(2+) signaling. PMID: 25304289
  23. Selective photostimulation of astrocytes with channelrhodopsin-2 in primary visual cortex enhances both excitatory and inhibitory synaptic transmission, through the activation of type 1a metabotropic glutamate receptors. PMID: 24500276
  24. Results provide unequivocal demonstration of the intrasynaptic localization of mGlu1 receptors in GABAergic synapses and confirm their peri-junctional enrichment in glutamatergic synapses PMID: 25377770
  25. Activation of mGluR1 facilitates firing of molecular layer interneurons through the TRPC1-mediated inward current, which depends on not only G protein-dependent but also Src-ERK1/2-dependent signaling pathways. PMID: 25181481
  26. Homer 1a was neuroprotective against traumatic brain injury in vitro and in vivo, and this neuroprotection was associated with its effects on group I metabotropic glutamate receptors. PMID: 24722299
  27. Stimulation of mGluR1 during glutamate exposure mediates prolonged epileptiform discharges in the hippocampus. PMID: 25568123
  28. Transcriptome sequencing of melanocytic nevi and melanomas from Grm1 transgenic mice to determine melanoma driver mutations. PMID: 24661573
  29. a potential crosstalk network between mGluR1 and tyrosine kinase, insulin-like growth factor 1 receptor (IGF-1R). PMID: 24628914
  30. Results suggest a role for mGluR1 in breast cancer as a pro-angiogenic factor as well as a mediator of tumor progression. PMID: 24633367
  31. Results indicate that mGlu1 receptor-mediated activation of phospholipase C within the shell subregion of the nucleus accumbens is an intracellular signaling pathway involved in the maintenance of alcohol intake by mice under limited access procedures PMID: 24467847
  32. Results demonstrate that a lower constitutive level of mGluR1 has a significant positive impact on mice with experimental ALS, providing a rationale for future pharmacological approaches to ALS by selectively blocking Group I metabotropic Glu receptors PMID: 24361555
  33. Binge alcohol drinking increases mGluR1 signaling within the central nucleus of the amygdala. PMID: 23966068
  34. activation of both Group I and Group II metabotropic glutamatergic receptors suppress retinogeniculate transmission PMID: 23558090
  35. We conclude that the long C-terminal domain of mGluR1a is required for the proper perisynaptic targeting of mGluR1 and cerebellar function PMID: 24523559
  36. The Grm1(crv4) mouse with a spontaneous mutation inactivating the metabotropic glutamate type 1 receptor show overexpression of metabotropic glutamate type 5 receptor and enhanced glutamate release worsening motor-coordination defects in these mice. PMID: 22791805
  37. mGluR1 recruitment to lipid rafts is enhanced by agonist binding and is supported at least in part by an intact cholesterol recognition/interaction amino acid consensus (CRAC) motif in the receptor. PMID: 24045944
  38. The activation of mGluR1,5 is likely a potential therapeutic strategy to prevent nervous tissues from excitotoxicity by reducing the impairment of the astrocytes and GABAergic neurons during the early stage of ischemia. PMID: 23280324
  39. mGluR1,5 activation improves the anxiety-like behaviors of DBA/2 mice. PMID: 22681774
  40. Both cytokines as well as cellular immune escape mechanisms seem to contribute to the observed immunosuppressed state of tumor-bearing grm1-transgenic mice. PMID: 22674057
  41. Tg(Grm1)EPv melanoma model exhibits more extensive metastasis into distant organs than previously described. Disseminated cells undergo phenotypic changes, as we observed high numbers of non-pigmented Grm1-expressing melanoma cells within distant organs. PMID: 22882420
  42. Transient stimulation of mGluR1 alters receptor properties, rendering them persistently active in the absence of endogenous activation. PMID: 23392681
  43. metabotropic glutamate receptor 1 is involved in 17beta-estradiol and NMDA-induced neuronal death PMID: 23077075
  44. transient receptor potential 3 which is also needed for mGluR1-dependent slow excitatory postsynaptic potentials and motor coordination and associates with protein kinase C gamma PMID: 23115168
  45. Data suggest that both T-type and P/Q-type Ca(2+) channels, but not TRPC3 or other Ca(2+) -permeable channels, are involved in mGluR1 and PKC signaling leading to the inhibition of dendritic growth in cerebellar Purkinje cells. PMID: 22188405
  46. Group I mGluRs are a potentially important source of neuromodulation within the spinal cord that can modulate the intensity of motoneuron output during motor behavior. PMID: 21346211
  47. Disruption of mGluR1 signaling at parallel fiber-Purkinje cell synapses is a major synaptic defect in sg/sg mutant mice, correlating with spinocerebellar ataxia (SCA) type 1 pathology in the extreme mouse model. PMID: 21558162
  48. novel insights into the mechanisms of intracellular Ca(2+) mobilization by mGluR5 in the somata of hippocampal neurons PMID: 22028929
  49. Low-frequency potentiation of mossy fiber excitatory postsynaptic potentials (EPSP) requires postsynaptic mGlu1 receptors for induction but is expressed presynaptically as an increased release probability. PMID: 22114260
  50. Genetic reduction of mGluR1 modified a few select Fmr1 knockout behaviors PMID: 21571007

Show More

Hide All

Subcellular Location
Cell membrane; Multi-pass membrane protein.
Protein Families
G-protein coupled receptor 3 family
Database Links
icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1