Recombinant Mouse Neuromedin-U (Nmu), partial

1. These data indicate a novel role for the peripheral NMU system, providing new insights into the pathogenesis of NAFLD/NASH. PMID: 29017855
2. Loss of NMU-NMUR1 signalling reduced ILC2 frequency and effector function, and altered transcriptional programs following allergen challenge in vivo. Thus, NMUR1 signalling promotes inflammatory ILC2 responses, highlighting the importance of neuro-immune crosstalk in allergic inflammation at mucosal surfaces. PMID: 28902842
3. data indicate that the NMU-NMUR1 neuronal signaling circuit provides a selective mechanism through which the enteric nervous system and innate immune system integrate to promote rapid type 2 cytokine responses that can induce anti-microbial, inflammatory and tissue-protective type 2 responses at mucosal sites PMID: 28869965
4. NMU treatment in vivo resulted in immediate protective type 2 responses; accordingly, group 2 innate lymphoid cells -autonomous ablation of Nmur1 led to impaired type 2 responses and poor control of worm infection PMID: 28869974
5. These results suggested that NMU can act directly on beta cells through NMUR1 in an autocrine or paracrine fashion to suppress insulin secretion. Collectively, our results highlight the crucial role of NMU in suppressing pancreatic insulin secretion, and may improve our understanding of glucose homeostasis. PMID: 28864416
6. These results suggest that NMU and NMS are involved in thermoregulation via the prostaglandin E2 and beta3 adrenergic receptors, but that endogenous NMS might play a more predominant role than NMU. PMID: 26826380
7. the anorectic effect of the lipidated NMU is partly mediated by a decrease in gastric emptying which is subject to tachyphylaxis after continuous dosing. PMID: 25895852
8. Beta-adrenergic and cholinergic mechanisms are involved in the anxiolytic action of neuromedin-U. PMID: 23892031
9. Data show that neuromedin U (NMU)-deficient mice developed less severe arthritis than control mice. PMID: 22314006
10. investigation of neuromedin U effects on factors associated with obesity/diabetes: NMU reduced food consumption/body weight; NMU increased body temperature/metabolic rate; NMU improved glucose tolerance; these effects seem to be mediated by NMUR1 PMID: 21586559
11. Analysis of NMU expression in ob/ob mice revealed elevated NMU mRNA levels in the dorsomedial hypothalamic (DMH) nucleus of ob/ob mice compared to lean litter-mates. NMU mRNA levels were elevated in the DMH of mice fasted for 24 h relative to controls PMID: 14622096
12. results suggest that endogenous NMU may be involved in reflexes and adaptation to environmental stimuli PMID: 15369794
13. NMU plays an important role in the regulation of feeding behavior and energy metabolism independent of the leptin signaling pathway. PMID: 15448684
14. NMU receptor antagonists could be novel targets for pharmacological inhibition of allergic inflammatory diseases, including asthma. PMID: 16373672
15. data suggest that LPS-induced IL-6 expression is partly dependent on autocrine/paracrine activation of the NMU-NMU-R1 signals in macrophages PMID: 16466693
16. A study evaluating smooth muscle contraction in NMU1 receptor knockout mouse was used to determine which receptor subtype mediates the contractile responses generated by neuromedin in the mouse.[NMU1 receptor] PMID: 16474416
17. results indicate that NMU suppresses gonadotropin secretion and regulates the onset of puberty PMID: 16716306
18. Central control of bone remodeling by Nmu is reported. PMID: 17873881
19. negative regulator of bone formation through the molecular clock PMID: 18761104
20. proNMU(104-136) is a novel modulator of energy balance and may contribute to the phenotype exhibited by NMU knockout mice. PMID: 19531638

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KEGG: mmu:56183

STRING: 10090.ENSMUSP00000031146

UniGene: Mm.154879