Recombinant Mouse Pancreas/duodenum homeobox protein 1 (Pdx1)

1. Maturation of pancreatic beta-cells requires Pdx1 function in cooperation with Foxa2. PMID: 28580283
2. The dynamic undifferentiated cell states within the male germline expressing PDX1 have been found and characterized. PMID: 30026551
3. results indicated that conditioned medium, just as critical components of the stem cell niche associated with other factors, such as Pdx1, had high potential to differentiate mESCs into IPCs PMID: 29637395
4. the present study demonstrated that Pdx1+/-/Alzheimer mice exhibit enhanced cognitive decline, amyloid-beta plaque deposition, tau hyperphosphorylation, the loss of synaptic spine protein, and activation of microglia and astrocytes. PMID: 27406855
5. This study showed that altered Pdx1 mRNA and protein levels in weaned male mutant beta-cells were tightly linked with hyperglycemia, decreased beta-cell proliferation, reduced beta-cell area, and altered expression of Pdx1-bound genes that are important in beta-cell replication, endoplasmic reticulum function, and mitochondrial activity. PMID: 28705881
6. These results suggest that Oc1 and Pdx1 cooperate prior to their divergence, in pancreatic progenitors, to allow for proper differentiation and functional maturation of beta cells. PMID: 27292642
7. Data suggest that hepatocytes can be reprogrammed into insulin-producing cells in vivo by transfection of neurogenin-3, Pdx1, and MafA genes using non-viral hydrodynamics injection; this procedure was used in treatment of streptozotocin diabetes; fasting blood glucose was reduced to normal. (Pdx1 = pancreatic and duodenal homeobox 1; MafA = v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A) PMID: 28100871
8. Creating the Pdx1(DeltaAREAII) state after cells entered an insulin-expressing stage led to immature and dysfunctional islet beta cells carrying abnormal chromatin marking in vital beta-cell-associated genes. Therefore, trans-regulatory integration through Area II mediates a surprisingly extensive range of progenitor and beta-cell-specific Pdx1 functions. PMID: 27993987
9. The use of a GFP reporter knocked into the endogenous Pdx1 promoter allowed us to monitor pancreatic induction based on the expression of Pdx1, a pancreatic master transcription factor, and to isolate a pure Pdx1-GFP(+) population for downstream applications. PMID: 27181524
10. Upon neoplastic transformation, the role of PDX1 changes from tumor-suppressive to oncogenic PMID: 28087712
11. PDX1 role in beta-cell function and diabetes PMID: 28017717
12. Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation PMID: 26887806
13. These results suggest that Bax mediates beta-cell apoptosis in Pdx1-deficient diabetes. PMID: 27137932
14. the role of Epidermal Growth Factor (EGF) and Poly-L-Ornithine (PLO) and PDX1 on human amnion epithelial cell differentiation process, is reported. PMID: 27068127
15. Ets-1 links glucotoxicity to pancreatic beta cell dysfunction through inhibiting PDX-1 expression in type 2 diabetes. PMID: 26564177
16. Pdx1+Sox9 co-occupy regulatory sequences of pancreatic and intestinal genes. Pdx1+Sox9 are necessary and sufficient to repress the intestinal fate choice. PMID: 26440894
17. The paper identifies two conserved Pdx1 binding sites in the epithelial cadherin (E-cad, Cdh1) promoter, and shows that Pdx1 directly binds and activates E-cad transcription. PMID: 26657766
18. Introduction of the PDX1 gene makes cells acquire a functional insulin secretory capacity PMID: 25817342
19. physiological and pathophysiological conditions dynamically regulated Pdx1 binding to these Swi/Snf complexes in vivo PMID: 25801033
20. The novel Pdx1-Clec16a-Nrdp1 pathway this study describes provides a genetic basis for the pathogenesis of mitochondrial dysfunction in multiple forms of diabetes. PMID: 26085571
21. Pdx1 protein levels are maintained in the setting of the UPR. PMID: 25251389
22. Data indicate that the ability of transcription factor Pdx1 to regulate genes in beta cells is partially dependent upon its methylation by methyltransferase Set7/9. PMID: 25713082
23. Results indicate sarco-endoplasmic reticulum calcium ATPase 2b (SERCA2b) as a transcriptional target of Pancreatic and duodenal homeobox protein 1 (Pdx-1). PMID: 25271154
24. Pdx1, USF1 and USF2 co-ordinately regulate Alx3 gene expression in pancreatic beta-cells. PMID: 25040025
25. The findings indicate that Pdx1 acts as a master regulator of beta cell fate by simultaneously activating genes essential for beta cell identity and repressing those associated with alpha cell identity. PMID: 24506867
26. Pdx1 gene expression was knocked down in mouse MIN6 insulinoma cells resulting in apoptotic cell death that was found to be associated with increased expression of BH3-only molecules Bim and Puma. PMID: 24658302
27. Data indicate that CK2 is a co-factor of PDX-1 in response to glucose in pancreatic beta-cells. PMID: 24126110
28. three transcription factors, PDX1, NGN3 and MAFA, are very important in pancreatic development. Overexpression of these three factors can reprogram both pancreatic exocrine and SOX9-positive cells of the liver into cells resembling pancreatic beta cells PMID: 24312421
29. Data indicate that mice in which Pdx1 was chronically repressed developed hamartomas in the gastro-duodenal domain. PMID: 23873371
30. The expression of exogenous Pdx-1 is sufficient to induce pancreatic differentiation in vitro. PMID: 23031216
31. Hes-1 downregulation allows PDX-1 to act as a major determinant of cholangiocyte proliferation in response to cholestatic injury. PMID: 23207146
32. These results suggest that a secreted luciferase reporter system in vivo enables not only the monitoring of promoter activity but also a quantitative and minimally invasive assessment of physiological and pathological changes in small cell masses. PMID: 24029239
33. Findings suggest that Pdx1 is not necessary for the postnatal formation of beta-cells but is essential for their full maturation to glucose-responsive beta-cells. PMID: 23775765
34. Pdx-1 activates islet alpha- and beta-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2. PMID: 23938296
35. PASK phosphorylates and inactivates GSK3beta, thereby preventing PDX-1 serine phosphorylation and alleviating GSK3beta-mediated PDX-1 protein degradation in pancreatic beta-cells. PMID: 23853095
36. Mouse mesenchymal stem cells differentiate into effective glucose-responsive insulin producing cells through recombinant lentiviral transduction of the pdx-1 gene in vitro. PMID: 23831626
37. Characterization of an apparently novel beta-cell line-enriched 80-88 kDa transcriptional activator of the MafA and Pdx1 genes. PMID: 23269676
38. PDX-1 is a therapeutic target for both hormonal symptoms and tumor volume in models of pancreatic cancer, insulinoma and islet neoplasia PMID: 22905092
39. GATA4 and GATA6 transcription factors bind to 2 conserved GATA sites in the conserved area III of Pdx1 which are required for promoter activity. Pdx1 is a direct target of GATA factors. PMID: 23006330
40. SSTR5 is a negative regulator for PDX-1 expression and SSTR5 may mediate the inhibitory effects of somatostatin and its analogs on insulin expression/secretion and cell proliferation via down-regulating PDX-1 PMID: 22669743
41. Pdx1 mediates lipid metabolism gene networks in intestinal cells and that maternal expression is essential for perinatal growth in mice. PMID: 22771330
42. Results indicate that Pdx1 and MafA drive DE progenitors towards insulin-producing cells. PMID: 22563503
43. At the chromatin level, histone tail modifications of the Pdx1, Ins1 (insulin 1) and Ins2 (insulin 2) gene promoters are shifted in a direction associated with gene activity PMID: 22150363
44. pdx1 may regulate lipid metabolism in the duodenum and iron transport across the duodenal intestinal mucosa. PMID: 22135308
45. Forced expression of PLAG1 under the control of the Pdx1 or Ngn3 promoter in murine pancreas induces different degrees of endocrine hormone imbalances. PMID: 21294959
46. Findings show that the utility of manipulating Pdx1 and Ngn3 expression in a stage-specific manner as an important new strategy for the efficient generation of functionally immature insulin-producing beta-islet cells from ES cells. PMID: 21931641
47. these results suggest that ATF3 inhibits PDX-1-mediated transactivation through the inhibition of p300-stimulated coactivation, which may lead to beta-cell dysfunction by ER stress. PMID: 21986529
48. Findings show that Pdx1 can work single-handedly as a potent context-dependent autonomous reprogramming agent, and suggest a postnatal differentiation evaluation stage involved in normal endocrine maturation. PMID: 21852533
49. these results demonstrate that ATF3 represses PDX-1 expression via binding to an ATF3-responsive element in its promoter, which plays an important role in suppression of pancreatic beta-cells function. PMID: 21821004
50. 14-3-3epsilon interacts directly with PDX-1 to regulate its cellular distribution in pancreatic beta cells. PMID: 21287435

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KEGG: mmu:18609

STRING: 10090.ENSMUSP00000082729

UniGene: Mm.389714