Recombinant Mouse Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1)

1. Study using IL-33-induced type 2 immunity signaling in a combination of cell lines, mouse models, and primary cells from mouse models reveal critical roles of IRAK-M and PIN1 in IL-33-induced type 2 immunity. Upon IL-33-induced inflammation, activated PIN1 binds to and catalyzes cis-trans isomerization of phosphorylated IRAK-M, inducing IRAK-M stabilization and nuclear translocation. PMID: 29686383
2. Pin1 serves as a modulator of SERCA2a and Na(2+)/Ca(2+) exchanger 1 Ca(2+) handling proteins, with loss of function resulting in impaired cardiomyocyte relaxation. PMID: 29018025
3. expressed in developing periodontal tissue, in vitro PDLCs and cementoblasts and role in periodontal regeneration PMID: 28198538
4. These results suggest that Pin1 promotes the progression of the mitotic cell cycle of SSC in steady-state, which is required for the sperm production from SSCs. PMID: 29432730
5. Pin1 silencing in lymphomas retarded disease progression in mice, making Pin1 an attractive therapeutic target in Myc-driven tumors. PMID: 26943576
6. Pin1 enhances adipocyte differentiation by regulating the function of PPARgamma. PMID: 27475846
7. Pin1 serves as a positive regulatory molecule of proplatelet formation of megakaryocytes by enhancing the function of phosphorylated tau. PMID: 28943044
8. Direct delivery of recombinant Pin1 via fibroin nanoparticle encapsulated cationic lipid complex successfully rescued osteoblast differentiation of pin-1 deficient cells. PMID: 27800612
9. Pin1 plays important role in the cell cycle progression and increase oval cells proliferation which may be crucial in chronic liver injury. PMID: 28214206
10. in vivo functional analyses of Pin1 in the GFAP-tTA;TRE-SmoA1 mouse model of Hedgehog-driven medulloblastoma demonstrate that the loss of Pin1 impairs tumor development and dramatically increases survival. PMID: 28167297
11. Data, including data from studies conducted with knockout mice, suggest that Pin1 (prolyl isomerase 1) expression in pancreatic beta-cells is markedly elevated in obesity from diet high in fat/sucrose; Pin1 appears to be involved in proliferation of beta-cells and in regulation of secretion of insulin; Pin1 interacts with Sik2 (salt-inducible kinase 2) to regulate calcium signaling. PMID: 28566287
12. Pin1 knockout in lupus-prone MRL lpr mice prevents expression of lupus phenotype. PMID: 27159270
13. By interacting with PSD-95, Pin1 dampens PSD-95 ability to complex with NMDARs, thus negatively affecting NMDAR signaling and spine morphology. PMID: 27194325
14. Oral administration of brown algae polyphenol, a Pin1 inhibitor, reduced fat buildup in mice. PMID: 28036348
15. The findings provide evidence for a putative novel role of PIN1 in the development of the nociceptive system and indicate phosphorylation-mediated conformational changes as a mechanism for regulating the PRRXL1 role in the process. PMID: 28049756
16. Data show that peptidyl-prolyl isomerase (Pin1) inhibition inhibits high glucose (HG)-induced cardiac fibroblasts (CFs) proliferation and migration. PMID: 27634219
17. Pin1 knock-out mice exhibited disturbed neuronal projections from the cerebral cortex and reduced white matter tracks. PMID: 26991250
18. Pin1 plays a vital role on the development of vascular inflammation and atherosclerosis in ApoE-/- mice. PMID: 28300760
19. Studies indicate that Prolyl Isomerase Pin1 (Pin1) Is highly involved in the development of metabolic syndrome. PMID: 27618008
20. results revealed a pivotal role of Pin1 in regulation of alcohol-induced mouse cardiomyocytes apoptosis by promoting reactive oxygen species (ROS) accumulation and repressing eNOS expression, which could be potential therapeutic targets for ACM. PMID: 26697133
21. diet containing high phosphate induces rapid renal fibrosis before a significant impact on renal function and Pin1 plays an important role in the fibrotic process. PMID: 26914452
22. Pin1 regulates the osteogenic activity of Osterix. PMID: 25463757
23. Pin1-dependent signaling represents a mechanism to modulate GABAergic transmission by regulating NL2/gephyrin interaction. PMID: 25297980
24. Thus, Pin1 could be developed as a major therapeutic target in many skeletal diseases PMID: 25187260
25. The identification of Pin1 as a factor involved in cell fusion contributes to the understanding of osteoclast-associated diseases, including osteoporosis, and opens new avenues for therapeutic targets. PMID: 24891219
26. Studied genome-wide mRNA expression microarray using the RNA isolation from Pin1 (+/+) and Pin1 (-/-) mouse embryonic fibroblast (MEF) cells. Signaling pathways regulated by Pin1 were analyzed with the utility of KEGG pathway and GO annotation. PMID: 23563987
27. Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A-Bora complex. PMID: 23970419
28. Pin1-mediated structural modification of Runx2 is an indispensable step connecting phosphorylation and acetylation and, consequently, transcriptional activation of Runx2 by FGF signaling PMID: 24509851
29. Pin1 has pleiotropic roles in CPCs and may be a molecular target to promote survival, enhance repair, improve differentiation, and antagonize senescence. PMID: 24375406
30. Pin1 is a novel regulator of osteoblast differentiation that acts through the regulation of Runx2 function. PMID: 24113655
31. Pin1 null mice exhibit low bone mass and attenuation of BMP signaling. PMID: 23675491
32. Identify a novel form of histone H1 regulation through phosphorylation-dependent pin1 mediated proline isomerization, which has consequences on overall H1 phosphorylation levels and the stability of H1 binding to chromatin. PMID: 24100296
33. Data indicate that Pin1 is up-regulated in dopaminergic neurons in cell culture, animal models, and human Parkinson disease (PD) brains. Pin1 inhibition protects dopaminergic neurons in PD models. PMID: 23754278
34. Study defines a D1-dopamine receptor-signaling pathway that potentiates the ability of mGluR5 to activate NMDARs and implicates this pathway in cocaine-induced plasticity; Pin1 catalysis on mGluR5(pS1126) is central to this signaling. PMID: 23911326
35. Pin1 and c-Myc are cooverexpressed in cancer, and this drives a gene expression pattern that is enriched in poor-outcome breast cancer subtypes. PMID: 23716601
36. UVA-induced COX-2 expression is mediated by Pin1 activation and is associated with malignant transformation of epidermal cells. PMID: 23380442
37. Data support a role for Pin1 as a central modulator of the intensity and duration of 2 major hypertrophic signaling pathways. PMID: 23487407
38. the isomerase activity of Pin1 inhibited PIP4K activity. PMID: 23193159
39. Pin1 expression remained constant but Pin1 posttranslational two-dimensional pattern was modified by tau overexpression in a tau-inducible mouse neuroblastoma cell line and in a THY-Tau22 mouse model of tauopathy PMID: 22926167
40. Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites PMID: 23362255
41. Pin1 KO mice were resistant to nonalcoholic steatohepatitis development. PMID: 23112047
42. Data indicate that peptidyl-prolyl isomerase Pin1(-/-) mouse embryonic fibroblasts (MEFs) showed higher cyclin-dependent kinase 10 (CDK10) expression than Pin1(+/+) MEFs. PMID: 22158035
43. Pin1 plays a critical role in tumorigenesis plausibly via physical interaction with RSK2 and reciprocal phosphorylation PMID: 22562304
44. Results indicate that peptidyl-prolyl isomerase Pin1 Associates with Smad3 and Smad6. PMID: 22613712
45. Pin1 is a regulator of neural progenitor cell differentiation by acting on beta-catenin and provides a new postphosphorylation signaling mechanism to regulate developmental stage-specific functioning of beta-catenin signaling in neuronal differentiation. PMID: 22645310
46. Physiological levels of Pin1 are important to control the intracellular localization and metabolic fate of Thr668-phosphorylated AbetaPP. PMID: 22430533
47. Pin1 down-regulation could be a potential approach in obesity-related dysfunctions, such as high blood pressure, diabetes, non-alcoholic steatohepatitis. PMID: 22412843
48. Pin1 binds the hydrophobic motif of conventional PKC isozymes to catalyze the isomerization of the phospho-Thr-Pro peptide bond at the turn motif, thus converting these PKC isozymes into species that can be efficiently down-regulated following activation. PMID: 22318721
49. Via regulation of CD8+ cDC production, Pin1 may serve as an important modulator of adaptive immunity. PMID: 22238658
50. Pin1 overexpression in the liver of the experimental mice attenuated acute liver injury induced by carbon tetrachloride. PMID: 22192799

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KEGG: mmu:23988

STRING: 10090.ENSMUSP00000034689

UniGene: Mm.7906