Recombinant Mouse Serine racemase (Srr)

1. Study to demonstrate that serine racemase inhibitor alleviates neuronal ischemic injury. Serine racemase inhibition acts on the neurovascular unit as a neuroprotectant and ameliorant of reductions in regional cerebral blood flow. PMID: 27693471
2. These findings reveal the NMDAR-independent roles of SR in metabolism and cell survival. PMID: 27585868
3. These data reveal the first evidence that Srr may regulate glucose homeostasis in peripheral tissues and provide circumstantial evidence that D-serine may be an endogenous islet NMDAR co-agonist in beta-cells. PMID: 27880078
4. This study demonstrated that SR deficiency reduces retinal pigment epithelial cells response to laser-induced inflammatory stimuli, resulting in decreased production of a cascade of pro-angiogenic cytokines, including(.) NO and VEGF, and reduced macrophage recruitment, which contribute synergistically to attenuated angiogenesis. PMID: 28892569
5. results indicate that SRR indeed acts as a d-Asp biosynthetic enzyme in some organs and/or tissues, and also provide evidences that there should be some additional enzyme for d-Asp synthesis in mammals. PMID: 27387750
6. data show neuronal serine racemase could regulate the extracellular D-serine signaling responsible for N-methyl-D-aspartate type glutamate receptor activation in the hippocampus PMID: 25782690
7. The retinal levels of d-serine are tightly controlled during the first week of postnatal life and vary according to deficiencies in Serine racemase. PMID: 25083578
8. In the neocortex and hippocampus only 24-40% of interneurons expressed serine racemase. PMID: 24436034
9. SR interacts with the synaptic proteins, postsynaptic density protein 95 (PSD-95) and stargazin, forming a ternary complex. PMID: 25164819
10. The findings of this study suggest that D-serine-dependent NMDAR activity is involved in mediating the cellular and behavioral effects of 5-HT2AR activation. PMID: 24269270
11. serine racemase in the skin epidermis is involved in the differentiation of epidermal keratinocytes and the formation of the skin barrier PMID: 24441099
12. Disruption of D-serine synthesis, by blocking SRR, during developmental stages leads to behavioral abnormalities relevant to prodromal symptoms and schizophrenia. PMID: 23630632
13. SRR and/or d-serine may be involved in the production of d-aspartic acid in mouse forebrains PMID: 23439386
14. The serine racemase-null mutant mouse has less than 10% of normal brain D-serine in a model of schizophrenia PMID: 23729812
15. The present findings suggest that serine racemase may be a target for the development of new therapeutic strategies for epileptic seizures. PMID: 22742962
16. Serine racemase is expressed by the main neuronal populations in most brain regions, irrespective of the excitatory or inhibitory nature of the cells. (Review) PMID: 22847782
17. Serine racemase is the major enzyme responsible for D-serine production in the mouse forebrain. Other pathways of D-serine production may exist in the brain and peripheral organs. PMID: 21906644
18. In forebrain, serine racemase is predominantly expressed in glutamatergic neurons, and co-release of glutamate and D-serine is required for optimal activation of post-synaptic NMDA receptors. PMID: 22362148
19. SRR-/- mice exhibited a significantly disrupted representation of the order of events in distinct experiences as showed by object recognition and odor sequence tests PMID: 21029376
20. Infarct volume following middle cerebral artery occlusion is dramatically diminished in several regions of the brains of serine racemase mutant mice despite evidence of increased NMDA receptor number and sensitivity. PMID: 20107067
21. Direct calcium binding results in activation in brain PMID: 12021263
22. Serine racemase is a bifunctional enzyme, producing both d-serine and pyruvate in cultured cells and in vitro PMID: 12393813
23. in addition to serine racemization, brain serine racemase also catalyzes specific elimination of L-serine to pyruvate; D-serine is eliminated much less efficiently PMID: 12560076
24. Modulation of serine racemase degradation provides a new mechanism for regulating brain d-serine levels and NMDA receptor activity. PMID: 16714286
25. These findings support a model whereby postsynaptic stimulation of nitric-oxide (NO) formation feeds back to presynaptic cells to S-nitrosylate SR and decrease D-serine availability to postsynaptic NMDA receptors. PMID: 17293453
26. This is the first report of neuronal expression of D-serine and serine racemase in the veretebrate retina during development. PMID: 17976164
27. plays a role in biosynthesis of free D-amino acid. PMID: 18516911
28. REsults suggest that serine racemase is expressed in many types of neurons in the brain and plays a key role in the regulation of brain functions under physiological and pathological conditions via the production of the neuromodulator D-serine. PMID: 18698599
29. this study show that genetically modified mice lacking the ability to produce D-serine endogenously have profoundly altered glutamatergic neurotransmission, and relatively subtle but significant behavioral abnormalities. PMID: 19065142
30. Srr mutant mice display behavioral phenotypes relevant to schizophrenia. PMID: 19483194

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KEGG: mmu:27364

STRING: 10090.ENSMUSP00000067552

UniGene: Mm.131443