Recombinant Mouse Small ubiquitin-related modifier 1 (Sumo1)

1. These findings indicate that SUMO1-conjugation of synaptic proteins does not occur or is extremely rare and hence not detectable using current methodology. PMID: 28598330
2. Study found expression of several mutated forms of SOD1 in the NSC-34 motor neuronal cells induces the formation of cytosolic and sometimes nuclear aggregates containing the SUMO-1 protein and showed that the formation of these aggregates can be modulated by action on the K75 SUMOylation site PMID: 26605782
3. These findings point to a significant contribution of SUMO1 modification on neuronal function which may have implications for mechanisms involved in mental retardation and neurodegeneration. PMID: 26022678
4. PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence. PMID: 26578773
5. SUMO1 accelerates the accumulation of autophagic vacuoles and promotes Abeta production. PMID: 25484073
6. The present study used immunohistochemical and immunoblot analysis with the different developmental stages of mice and demonstrated the developmentally regulated distribution of SUMO1. PMID: 24639124
7. The results of this study indicate that post-translational modifications of SERCA2a caused by the toxic environment of the hypertrophied and failing myocardium can be prevented by SUMO-1. PMID: 24893265
8. SUMO-1 plays crucial roles for spindle organization, chromosome congression, and chromosome segregation during mouse oocyte meiotic maturation. PMID: 25123474
9. Adult mice showed proportionately greater increases in SUMO-1 than the aged group. PMID: 23583339
10. Increasing SUMOylation in astrocytes, by over-expression of constitutively active SUMO-1, but not its inactive mutant, abrogated Abeta-induced increase in GFAP, suggesting astrocytes require SUMO-1 conjugation to remain non-reactive. PMID: 23651519
11. Sumo1 Heterozygosity Rescues Senp1 Mutant Defects. PMID: 23684609
12. SUMO-1 is elevated in the brain of Alzheimer disease model mice. PMID: 22975420
13. SUMOylation of pancreatic glucokinase regulates its cellular stability and activity PMID: 23297408
14. Mutant lamin A/C alters the dynamics of sumo1 and thus misregulation of sumoylation may be contributing to disease progression in laminopathies. PMID: 23029315
15. identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice PMID: 23213215
16. SUMO1 covalently modifies Blimp-1 at lysine 816 PMID: 22555612
17. Alterations in SUMO substrate conjugation may occur and global posttranslational modifications by ubiquitin may play an important role in the mechanisms underlying an Alzheimer disease model. PMID: 21843595
18. SUMO-1 knockout mice developed congenital heart defects, atrial septal defects, and ventricular septal defects, coincident with the dysregulation of genes involved in cell proliferation. PMID: 21563299
19. levels of SUMO1 and the SUMOylation of SERCA2a itself were greatly reduced in failing hearts PMID: 21900893
20. The results of this study showed that the SUMO-1 protein interacts with mutant ataxin-1 and colocalizes with its aggregates which suggests the involvement of the SUMO-1 system in the pathogenesis of SCA1 disease. PMID: 21308649
21. oncogenic Ras efficiently activates the ERK pathway both by activating Raf and by inhibiting MEK SUMOylation, thereby inducing carcinogenesis PMID: 21336309
22. SUMO1 sumoylation activates p32 Pax-6 in both DNA-binding and transcriptional activities PMID: 21084637
23. Studies define an important role of PIASy in hypoxia signaling through promoting HIF1alpha SUMOylation. PMID: 20661221
24. SUMO-1 (small ubiquitin-related modifier) is found to regulate unfolded protein response activation and endoplasmic reticulum homeostasis. PMID: 20408817
25. N4BP1 can be conjugated with SUMO1 and that this abrogates N4BP1 ubiquitylation. PMID: 20233849
26. Histone deacetylase 1 is a substrate for SUMO-1 (small ubiquitin-related modifier) modification in vitro and in vivo PMID: 11960997
27. activation of SUMO-1 system in polyglutamine diseases PMID: 12054600
28. induction of modification by PIAS3 PMID: 12387893
29. results suggest that a functional link between SUMO-1 and PR is of physiological importance for the local modulation of PR-mediated events in the ovary PMID: 14500579
30. Increased levels of SUMO-1 participate in the modulation of HIF-1alpha function through sumoylation in brain and heart. PMID: 15225651
31. GATA4 is a SUMO-1-targeted transcription factor and together with PIAS1 is a potent regulator of cardiac gene activity PMID: 15337742
32. Testicular expression of small ubiquitin-related modifier-1 (SUMO-1) supports multiple roles in spermatogenesis: silencing of sex chromosomes in spermatocytes, spermatid microtubule nucleation, and nuclear reshaping. PMID: 15950612
33. Via sumoylation SUMO-1 has an important role in the regulation of granulosa cell apoptosis during granulosa cell differentiation in the mouse ovary. PMID: 16175636
34. We show that Msx1 conjugation to SUMO-1 in vivo is enhanced by an E3 SUMO ligase. PMID: 16678795
35. findings show that Sumo1 is expressed in the developing lip and palate and that a Sumo1 hypomorphic allele manifests an incompletely penetrant orofacial clefting phenotype PMID: 16990542
36. Results demonstrate the post-translational modification of endogenous Oct-4 by SUMO-1 and the role of sumoylation in regulating Oct-4 protein stability and function. PMID: 17496161
37. The small ubiquitin-like protein SUMO-1 can modify MafB in vitro and in vivo on lysines 32 and 297. PMID: 17548468
38. These results support the notion that most, if not all, SUMO-1 functions are compensated for in vivo by SUMO-2 and SUMO-3. PMID: 18573887
39. The function of calcium/calmodulin-dependent serine protein kinase (CASK), a MAGUK protein, in dendritic spine formation by RNA interference, is analyzed. PMID: 18606847
40. SUMO-1 further enhances the suppression of cell growth through stabilization of RbAp46 protein. This is the first report to demonstrate that SUMO-1 can suppress Ras-related cell proliferation through stabilization of RbAp46 protein. PMID: 19189660
41. Maintenance of a globally elevated SUMO-1 conjugation level as revealed by immunoblot assays is a component of ischemic tolerance. PMID: 19200349
42. Adenosine signaling mediates SUMO-1 modification of IkappaBalpha during hypoxia and reoxygenation. PMID: 19297320
43. c-Maf can be modified at lys 33 by SUMO-1; c-Maf sumoylation contributes to immune deviation in type 1 diabetes by reducing c-Maf access to and transactivation of the IL-4 gene PMID: 19553542

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KEGG: mmu:22218

STRING: 10090.ENSMUSP00000088935

UniGene: Mm.362118