Recombinant Mouse Sodium- and chloride-dependent GABA transporter 1 (Slc6a1), partial

1. the expression of inhibitory neurotransmitter transporters GlyT1, GAT-1, and GAT-3 in inferior colliculus and hippocampus astrocytes, was examined. PMID: 29370841
2. Results demonstrated that GAT-1-/- mice have phenotypes of hyperactivity, impaired sustained attention and learning deficiency, and the performance of GAT-1-/- mice is similar to ADHD symptoms. PMID: 26072958
3. Results demonstrate that high-affinity activation by GABA of GAT1 transporters provokes release of [3H]GABA from nerve terminals by different mechanisms PMID: 25150942
4. these data show that during paclitaxel-induced neuropathic pain there is significant increase in GAT-1 expression in the ACC. GAT-1 is the main transporter of GABA from the synapse PMID: 25700370
5. Development of GABA-removal system and its relationship to development of GABAergic networks studied by examination of changes in GAT-1 and GAT-3 expression and localization in embryonic and postnatal mouse spinal cord PMID: 24412234
6. GAT1 plays a critical role in the regulation of rapid eye movement (REM) sleep and homeostasis of non-REM sleep. PMID: 24155871
7. results suggest that GAT1 ko mouse is a new animal model for ADHD studying and GAT1 may be a new target to treat ADHD PMID: 23656791
8. We failed to provide proof-of-concept evidence that lower PV and GAT1 expression in schizophrenia are a consequence of lower GAD67 expression PMID: 23103418
9. Results suggest that a moderate reduction in GAT1 activity causes the enhancement of learning and memory in mice. PMID: 22318715
10. We used immunohistochemistry to analyze the spatiotemporal patterns of GABA and GABA Transporter-1 (GAT1) immunoreactivities in the developing and adult mouse amygdala PMID: 21382352
11. the terminal sialic acid of N-linked oligosaccharides of GAT1 plays a crucial role in the gamma aminobutyric acid transport process PMID: 21045010
12. GABA Transporter Mutagenesis Database (GATMD), a web-accessible, relational database of manually annotated biochemical, functional and pharmacological data reported on GAT1. PMID: 21131297
13. abnormal expression of GAT1 could result in spermiogenesis function injury, sperm paramorphia and dysgenesis. PMID: 19938951
14. GAT1 deletion reduces the frequency of hippocampal theta oscillation in vivo; behavioral studies show that GAT1 knock-out mice exhibit impaired hippocampus-dependent learning and memory. PMID: 20016099
15. GAT1 deficiency leads to enhanced extracellular GABA levels resulting in an overactivation of hippocampal GABA-A receptors responsible for a postsynaptic tonic conductance. PMID: 12815026
16. The rewarding effects induced by morphine were significantly decreased in GAT1-overexpressing mice as measured by the conditioned place preference (CPP) paradigm. Morphine withdrawal symptoms were substantially reduced in GAT1-overexpressing mice. PMID: 14598306
17. GAT1 abnormal expression may result in gonadal dysgenesis and might be therapeutically targeted for contraception or dysgenesis treatment. PMID: 15040890
18. It is concluded that GABA GAT-1 transporters and glutamate transporters coexist on the same spinal cord glutamatergic terminals. Activation of these GABA transporters elicits release of glutamate partially by reversal of glutamate transporters. PMID: 15789377
19. results identify the transport mode and the channel mode of GAT1 and also raise the possibility of separating these components in a physiological environment PMID: 16150932
20. Increased GABA transporters is associated with Niemann-Pick disease, type C PMID: 16429462
21. These results showed that the absence of GAT1 affects mental status through enhancing the GABAergic system, as well as modifying the serotonergic system and the hypothalamic-pituitary-adrenal (HPA) activity in mice. PMID: 17164814
22. An important target involved in the regulation of aggressive behavior in mice; long-term dysfunction of GAT1 may result in the alteration of testosterone secretion, seen in gt1 knockout mice. PMID: 17183588
23. Both acute and partial block of GAT1 increased the sensitivity of mice to GABAergic sedative/hypnotic drugs, whereas permanent GAT1 dysfunction in the GAT1(-/-) mice decreased the sensitivity to some extent. PMID: 17655829
24. GAT-1 plays a prominant role in both tonic and phasic GABA(A) receptor inhibition, in particular during systained neuronal activity. PMID: 18248614
25. The effects of DAT KO in animal models of depression are larger than those produced by NET or SERT KO, and unlikely to be simply the result of the confounding effects of locomotor hyperactivity. PMID: 18690111
26. In the developing murine postnatal neostriatum GAT-1 operates in a net uptake mode. It prevents the persistent activation of presynaptic GABA(B)Rs (P12-34) and prevents (P7-14) or reduces (P19-34) tonic postsynaptic GABA(A)R activity. PMID: 18832421
27. These findings demonstrate that GABA uptake and release via GAT-1, GAT-3, and VGAT are initially established in the inner retina during the first postnatal week and that these systems then mature in the outer retina during the second postnatal week. PMID: 18975268
28. GAT-1 is a critical modulator in T cell-mediated immune responses and in the pathogenesis of experimental autoimmune encephalomyelitis, the animal model of multiple sclerosis. PMID: 19050239
29. Actin confines GAT1 to the plasma membrane via ezrin, and this interaction is mediated through the PDZ-interacting domain of GAT1. PMID: 19348776
30. GAT-1 expression on T lymphocytes is modulated by protein kinase C activation; GAT-1 deficiency induces more vigorous cell cycle entry and less cell apoptosis in T cells, thus leading to enhanced cell proliferation. PMID: 19667098
31. The gamma-aminobutyric acid transporter 1 protomer exists in membranes as dimers and higher order oligomers. Important C-terminal motifs are critical in oligomer assembly and trafficking. PMID: 19948998

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KEGG: mmu:232333

STRING: 10090.ENSMUSP00000032454

UniGene: Mm.5260