Recombinant Mouse TIR domain-containing adapter molecule 2 (Ticam2)

1. Using ovalbumin as model antigen, the authors showed that exposure of dendritic cells to hyperosmolarity strongly inhibits activation of antigen-specific T cells despite enhancement of antigen uptake, processing and presentation. They identified TRIF as key mediator of this phenomenon. PMID: 28331179
2. the present study indicated that MyD88 and TRIF blockades serve notable and equivalent roles in protecting cardiac deterioration from severe sepsis by attenuating cytokine release, reducing neutrophil infiltration and alleviating apoptosis. PMID: 29115392
3. lipopolysaccharide (LPS) application induces proliferation of dormant hematopoietic stem cells (HSC) and impairs HSC self-renewal via TLR4-TRIF-ROS-p38 signaling. PMID: 28736216
4. These results indicate a critical role for Ticam2 in SARS-CoV disease, and highlight the importance of host genetic variation in disease responses. PMID: 28592648
5. Distinct mechanisms downstream of TLR4 signaling mediate myelosuppression and hematopoietic stem cell exhaustion during sepsis through unique effects of MyD88 and TRIF. PMID: 27264973
6. these data show that both Myd88 and TRIF are necessary for Th17 differentiation in the lungs in response to immunization with lipopolysaccharide PMID: 27328989
7. Stimulation of the TLR4-TRIF pathway can protect against the development of allergic airway disease and that a TRIF-dependent adjuvant effect on CD4(+) ICOS(+) T-cell responses may be a contributing mechanism. PMID: 28502093
8. Monophosphoryl lipid A stimulation of a TLR4-TRIF-PI3K-Akt pathway prevents lipopolysaccharide-induced ERK activation in the medullar thick ascending limb. PMID: 28356284
9. study reporst a key role for TNF/TNFR1 in Yersinia-induced cell death of murine macrophages, which occurs despite the blockade of NF-kappaB and MAPK signaling imposed by Yersinia on infected cells PMID: 27733552
10. the role of Toll-like receptor (TLR) 2, TLR4, myeloid differentiation response gene 88, and Toll-IL-1 receptor domain-containing adaptor-inducing interferon-gamma (TRIF), factors critically involved in the TLR signaling pathway, was studied in experimental autoimmune neuritis. PMID: 27842213
11. Juniperus rigida Sieb. extract inhibits macrophage inflammatory responses by attenuating TRIF-dependent signaling and inflammasome activation. PMID: 27260408
12. TRIF mediates antibacterial defense during Gram-negative pneumonia, at least in part, by inducing IFN-x03B3; at the primary site of infection. PMID: 26065469
13. MMP-12 up-regulation mediated by SARM-TRIF signaling pathway contributes to IFN-gamma-independent airway inflammation and AHR post RSV infection in nude mice. PMID: 25652021
14. HMGB1 and its downstream TLR4/Myd88/TRIF signaling pathway play important roles in the mouse intestinal I/R injury. PMID: 26217083
15. TLR4, TRIF, and MyD88 mediate the intraocular inflammatory response in endophthalmitis caused by Bacillus cereus. PMID: 26195555
16. TRIF is a mediator of the innate and adaptive immune interactions in the protective properties of memory immunity against Gram-negative bacteria. PMID: 26351279
17. Inhibitory effects of SP were mediated through the regulation of TRIF-dependent signaling. PMID: 25747147
18. These findings indicate that a balanced immune response operating through both TRIF-driven and MyD88-driven pathways likely provides the most effective host cell intrinsic antiviral defense responses to severe SARS-CoV disease PMID: 26015500
19. TIR-domain-containing adapter-inducing interferon-beta (TRIF) regulates Th17-mediated intestinal immunopathology in colitis PMID: 25073675
20. TRIF promotes angiotensin II-induced cross-talk between fibroblasts and macrophages in atrial fibrosis. PMID: 26056004
21. MyD88 and TRIF pathways differently regulate TLR4-induced immune responses in B cells. PMID: 25448706
22. Data suggest that both TIR-domain-containing adapter-inducing interferon-beta (TRIF) and myeloid differentiation factor 88 (MyD88) are essential for the activation and maturation of dendritic cells in response to Mycobacterium tuberculosis Hsp70 (Mtb Hsp70). PMID: 25461391
23. role in development of Th17 immunity in neutrophilic asthma PMID: 24985082
24. Type I interferon has a role in the bias that Toll-like receptor 4 exhibits for signaling mediated by the adaptor protein TRIF PMID: 25389373
25. HIS exerted potent anti-inflammatory effects via the regulation of TRIF-dependent signaling. PMID: 25689174
26. TRIF-dependent innate immune activation is critical for survival to neonatal gram-negative sepsis. PMID: 25548220
27. a previously unknown function of the DDX21-TRIF-S100A9-TLR4-MyD88 signaling network in regulating inflammation during infection. PMID: 24391503
28. PTX3 binds MD-2 and promotes TRIF-dependent immune protection in aspergillosis. PMID: 25049357
29. SARM expression was reduced and TRIF expression was increased after respiratory syncytial virus infection. PMID: 24478430
30. neither the unfolded protein response transcription factors XBP1 and CHOP nor the TLR4 adaptor molecule MyD88 is necessary for caspase-8 activation. Instead, both caspase activation and IL-1beta production require the alternative TLR4 adaptor TRIF. PMID: 24489101
31. a critical role for Arf6 in regulating Tram/Trif-dependent TLR4 signaling. PMID: 24297182
32. Recruitment of TLR adapter TRIF to TLR4 signaling complex is mediated by the second helical region of TRIF TIR domain. PMID: 24194546
33. data indicate that LDL affects the TNF-alpha and IL-6 response of macrophages to P. gingivalis challenge and that MyD88 and TRIF play important roles in P. gingivalis-elicited foam cell formation. PMID: 23194377
34. signaling through the TLR4 and TRIF pathways limits skin barrier dysfunction, cutaneous allergic sensitization, and proinflammatory cytokine production. PMID: 23997219
35. Both TRIF and IPS-1 adaptor proteins contribute to the cerebral innate immune response against herpes simplex virus 1 infection. PMID: 23596298
36. Palmitate & lipopolysaccharides led to a macrophage death pathway requiring TLR4 signaling via TRIF but independent of NF-kappaB, MAPKs, and IRF3. PMID: 23275600
37. involvement in liver reperfusion injury not found PMID: 22911673
38. TRIF plays a modest role in protection from Sindbis-induced neurologic disease. PMID: 23084425
39. IgG class switch was mediated by TIR-domain-containing adapter inducing interferon-beta (TRIF), but not by MyD88. PMID: 23144170
40. MyD88- and TRIF-dependent signaling has a differential contribution to host defense in different cell types that changes from early- to late-stage gram-negative pneumonia. PMID: 22904341
41. Caspase-11 activation via the TLR4-TRIF-IFNbeta pathway synergizes with the NLRP3 pathway to coordinate caspase-1-dependent IL-1beta and IL-18 secretion and also leads to caspase-1-independent cell death. PMID: 22819539
42. This study reveals a central role of MyD88 and a counterregulatory function of TRIF in T cell-driven arthritis. PMID: 22147588
43. This study indicated that TRIF deficiency promotes ON axon regeneration by attenuating microglial activation and consequently reducing the release of harmful cytokines via NF-kappaB inactivation. PMID: 22361049
44. TLR2 and TRIF are two critical components leading to the induction of the IFN-beta gene during Listeria infection. PMID: 22432012
45. The findings of the present study establish the importance of cardiac-specific TRIF-mediated signaling in the heart in acute viral myocarditis PMID: 21956162
46. Results highlight a critical role for TLR4 and TRIF-IRF3 signaling as the governing mechanism in the neuroprotective response to stroke. PMID: 21999375
47. The mechanism of TRIF-mediated protective immunity appears to be orchestrated by macrophage-induced IFN-beta and NK cell production of IFN-gamma. PMID: 22124111
48. gene knock-out mice develope worse acute and chronic CVB3 myocarditis with elevated levels of IL-33 PMID: 22013485
49. TRIF adaptor protein acts as a potent negative regulator of TLR agonist-triggered immune responses. PMID: 21760953
50. These data indicate distinct roles for MyD88 and Trif in IR-induced inflammation and suggest that chronic, undetected infections, such as Helicobacter, alter the use of the adaptor proteins to induce damage. PMID: 21056969

Show More

Hide All

KEGG: mmu:225471

STRING: 10090.ENSMUSP00000066239

UniGene: Mm.149280