Recombinant Mouse Transcription factor 4 (Tcf4)

1. The findings reveal the commitment and flexibility of E2-2high progenitor differentiation and imply that pertinent tuning machinery is present in the gut microenvironment. PMID: 29106601
2. TCF4 is broadly expressed in cortical and subcortical structures in the developing and adult mouse brain. Tcf4 haploinsufficiency in mice replicated structural brain anomalies observed in Pitt-Hopkins syndrome patients. PMID: 29588831
3. Our findings indicate that H2O2 inhibits NaV1.5 expression by activating the Wnt/b-catenin signaling and beta-catenin interacts with TCF4 to transcriptionally suppress cardiac NaV1.5 expression. PMID: 27068063
4. Hdac2 isoform-selective knockdown was sufficient to rescue memory deficits in Tcf4(+/-) mice. PMID: 27568567
5. We report that TCF4 comprises two transcriptional isoforms, both of which are required for optimal plasmacytoid DC development in vitro PMID: 27986456
6. these data identified E2A and E2-2 as central regulators of B cell immunity. PMID: 27261530
7. down-regulation of Id3 in B cells is essential for releasing E2A and E2-2, which in a redundant manner are required for antigen-induced B cell differentiation. PMID: 27217539
8. TCF-4 as a co-activator of p65 in the potentiation of proinflammatory cytokine production in macrophages and aggravation of high-fat diet induced chronic inflammation and insulin resistance in mice. PMID: 27129186
9. Data indicate that upregulation of E2-2 protein markedly attenuated the inhibitor of DNA-binding 1 (ID1)-mediated increase in endothelial progenitor cells (EPCs) proliferation and migration. PMID: 27635429
10. This study demonstrated that Tcf4tg mice displayed significantly delayed conditioning when pre-exposed to the conditioned stimulus (12 kHz) but not when pre-exposed to a different stimulus PMID: 26404636
11. We conclude that E2-2 inhibited EPC proliferation via suppressing their autophagy, and E2-2 regulated EPC autophagy by mediating the expression of ATG7. PMID: 26986900
12. demonstrated that Id1 and E2-2 are critical regulators of EPCs function in vitro. Id1 interacts with E2-2 and relieves the E2-2-mediated repression of FGFR1 and VEGFR2 expression to modulate EPCs functions PMID: 26476925
13. TCF4 is a regulator of neuronal intrinsic excitability in part by repression of Kcnq1 and Scn10a. PMID: 26971948
14. A disease-promoting role of E2-2 dependent pDCs in the pancreas. PMID: 26624013
15. Genetic disruption of Itf2 on the Apc(Min/+) background results in earlier death and a significant increase in tumor number and size in the small intestine. PMID: 25869068
16. Results show that binding of the transcription factor Tcf4 correlates with hypo-methylation and demonstrate that Tcf4 is one of the factors contributing to formation of differentially methylated regions. PMID: 23714178
17. Wnt/beta-catenin stimulation may repress BACE1 transcription via binding of TCF4 to BACE1 gene, and therefore, activation of the Wnt pathway may hold the key to new treatments of Alzheimer disease PMID: 25384422
18. study suggests that CREPT acts as an activator to promote transcriptional activity of the beta-catenin.TCF4 complex in response to Wnt signaling. PMID: 24982424
19. Dendritic cell-specific Tcf4 haplodeficiency ameliorated systemic lupus erythematosus-like disease caused by the overexpression of the endosomal RNA sensor Tlr7. PMID: 25180061
20. beta-catenin patterns zonal liver metabolism together with Tcf-4, Hnf-4alpha, and xenobiotic nuclear receptors. PMID: 24214913
21. Zac1 interacts with two cis-regulatory elements in the Tcf4 gene locus. PMID: 24396065
22. The data of this study indicated that the reduced cognitive performance in Tcf4tg mice includes deficits at the level of attention and behavioral anticipation. PMID: 23069005
23. increased beta-catenin/Tcf4 levels i) correlated with reduced TRalpha1 transcriptional activity on its target genes and, ii) were likely responsible for the shift of TRalpha1 binding on WNT targets PMID: 22509275
24. We show that forced expression of Tcf4 or a stabilised beta-catenin mutant is sufficient to promote macrophage differentiation in response to GM-CSF and that GM-CSF can regulate beta-catenin stability, most likely via GSK3b. PMID: 22099176
25. miR-155 directly suppresses the expression of the transcription factor TCF4. PMID: 21460854
26. continuous expression maintains the cell fate of mature plasmacytoid dendritic cells PMID: 21145760
27. published beta-catenin coactivators p300 and BRG1 displayed a more pleiotropic target gene expression profile controlling Wnt and other pathways. tcf4, mllt10/af10, and dot1l are co-expressed in Wnt-driven tissues in zebrafish PMID: 21103407
28. Unlike other intrinsic regulators of fiber type, low levels of Tcf4 in myogenic cells promote both slow and fast myogenesis, thereby promoting overall maturation of muscle fiber type. PMID: 21177349
29. These observations provide insight for the first time into the physiological function of TCF4 in the adult brain and its possible contributions to neuropsychiatric disease condition. PMID: 20434134
30. analysis of control of TCF-4 expression by VDR and vitamin D in the mouse mammary gland and colorectal cancer cell lines PMID: 19924301
31. KLF4 directly interacts with TCF4 independently of beta-catenin and that KLF4 and TCF4 are expressed in similar patterns within the large intestine PMID: 19901072
32. E2-2 is required for optimal expansion of pre-B cells, E2-2 modulates the follicular vs marginal zone B-cell populations. PMID: 17082585
33. VMD2 is regulated by the MITF-TFE family through two E-boxes, with E-box 1 required for a direct interaction of MITF-TFE factors and E-box 2 for binding of the as yet unidentified factors PMID: 17085443
34. Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors PMID: 17878293
35. The bHLH transcription factors, splice variants, ITF-2A and ITF-2B, were identified as the Id1 and Id2 interacting protein during pregnancy. PMID: 18519032
36. SMRT and NCoR have important roles in the regulation of beta-catenin-TCF4-mediated gene transcription PMID: 18632669
37. These results identify E2-2 as a specific transcriptional regulator of the plasmacytoid dendritic cells lineage in mice and humans and reveal a key function of E proteins in the innate immune system. PMID: 18854153
38. The involvement of AR, beta-catenin, and TCF-4 pathway during androgen action to activate a number of Wnt target genes, including Fst, and cross communication with the Smad signaling pathway during myogenesis. PMID: 18948405
39. Data show that GFP directly reports Tcf4 activation in vivo and tracks the predicted increases in Tcf4 activation that result from Apc inactivation. PMID: 19263440
40. The identification of class I basic Helix-Loop-Helix factor E2-2 (TCF4/ITF2) as a new epithelial-mesenchymal transition regulator is reported. PMID: 19295128
41. Studies present the precise distribution of gene expression of canonical Wnt pathway transcriptional regulators, Tcf1, Lef1, Tcf3, Tcf4 and beta-catenin between PMID: 19303461
42. embryonic progenitor cells and postnatal hair follicle stem cells coexpress Tcf3 and Tcf4, which can act as transcriptional activators or repressors. PMID: 19718027

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KEGG: mmu:21413

STRING: 10090.ENSMUSP00000077577

UniGene: Mm.4269