Recombinant Mouse Tumor necrosis factor alpha-induced protein 8 (Tnfaip8)

Code CSB-YP835637MO
MSDS
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Source Yeast
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Code CSB-EP835637MO
MSDS
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Source E.coli
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Code CSB-EP835637MO-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP835637MO
MSDS
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Source Baculovirus
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Code CSB-MP835637MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Tnfaip8
Uniprot No.
Alternative Names
Tnfaip8; Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8
Species
Mus musculus (Mouse)
Expression Region
1-198
Target Protein Sequence
MLSEAEEPRE VATDVFNSKN LAVQAQKKIL GKMVSKSIAT TLIDDTSSEV LDELYRVTKE YTQNKKEAER VIKNLIKTVI KLAVLHRNNQ FNQDELALME KFKKKVHQLA MTVVSFHQVE YTFDRNVLSR LLNECRELLH EIIQRHLTAK SHGRVNNVFD HFSDCDFLAA LYNPFGKFKP HLQKLCDGIN KMLDEENI
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Acts as a negative mediator of apoptosis. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.
Gene References into Functions
  1. Study revealed that TIPE overexpression obviously augmented the volume and weight of the tumors, indicating that TIPE facilitates tumor formation probably through its antiapoptotic effect on JNK and p38 activation. PMID: 29620232
  2. TNFAIP8 expression following CLP may be associated with the pathogenesis of immune dysfunction in splenic T lymphocytes in mice. PMID: 29488604
  3. CD4+ T lymphocyte proliferative activity was significantly down-regulated when TNFAIP8 gene was silenced by siRNA in mice at 24 h post burn. Down-regulation of TNFAIP8 can significantly decrease expression levels of IL-2 and soluble IL-2R at 24 h after thermal injury. PMID: 27655497
  4. TNFAIP8 regulates RAC1 signaling during TNF-alphaR activation and L. monocytogenes invasion of cells and that this regulation is crucial for controlling cell death and lethal L. mono-cytogenes infection of mice. PMID: 25948813
  5. TIPE plays an important role in maintaining colon homeostasis and in protecting against colitis. PMID: 25948814
  6. Data indicate that mutant Tnfaip8/Oxi-alpha has been crystallized and X-ray data have been collected to 1.8 A using synchrotron radiation. PMID: 24637935
  7. Tnfaip8 expression is associated with susceptibility to Staphylococcus aureus sepsis. PMID: 20824097
  8. Data suggest that Galphai-TNFAIP8-mediated rescue of pre-oncogenic cells enhances progression to oncogenic transformation, providing a selective target to inhibit cellular transformation. PMID: 20607800
  9. Tnfaip8 is crucial in regulating glucocorticoid-mediated apoptosis of thymocytes PMID: 19730441

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Subcellular Location
Cytoplasm.
Protein Families
TNFAIP8 family
Database Links
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