Recombinant Mouse Tyrosine-protein phosphatase non-receptor type 1 (Ptpn1)

1. Findings collectively suggested that PTP1B ablation protects against ER stress-induced cardiac anomalies through regulation of autophagy. PMID: 28941626
2. Activity of PTP1B specifically in myeloid lineage cells protects against atherosclerotic plaque formation, under atherogenic conditions, in an ApoE-/- mice. PMID: 28752048
3. A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models. PMID: 29217773
4. PTP1B has a tumor suppressor function in myeloid lineage cells.PTP1B deficiency leads to shorter lifespan and the development of acute leukemia. PMID: 29122767
5. These results demonstrate a key role for PTP1B in the protection against the cytotoxicity of irradiation in intact animal and in macrophages, which might be therapeutically relevant. PMID: 29705509
6. PTP1B gene deletion significantly limited CLP-induced insulin resistance, improved AMP-activated protein kinase signaling pathway and Glucose Transporter 4 translocation, and decreased inflammation. These effects were associated with a reduction of sepsis-induced endothelial dysfunction/impaired NO production and especially of insulin-mediated dilatation. PMID: 28272165
7. Sleep fragmentation induces increased food intake, reduced leptin signaling in hypothalamus, systemic insulin resistance, and reduced visceral white adipose tissue insulin sensitivity and inflammation that are mediated by increased PTP-1B activity. PMID: 28651353
8. S-nitrosylation of endogenous SHP2 Phosphatase and PTP1B in endothelial insulin signaling has been demonstrated. PMID: 27521458
9. The findings show that reduced PTP1B responses contribute to disease symptoms in part by enhancing S100A9 expression during viral-associated chronic obstructive pulmonary disease exacerbations. PMID: 26813343
10. Under normoglycemia control and pod-PTP1B KO mice exhibited comparable renal functions. However, podocyte PTP1B disruption attenuated hyperglycemia-induced albuminuria and renal injury and preserved glucose control. Also, podocyte PTP1B disruption was accompanied with improved renal insulin signaling and enhanced autophagy with decreased inflammation and fibrosis. PMID: 28987240
11. Endothelial PTP1B deletion improves cardiac VEGF signalling and angiogenesis and protects against chronic afterload-induced heart failure. PMID: 27207947
12. The results suggest a deficiency of PTP1B improves hypothalamic insulin sensitivity resulting in the attenuation of AgRP mRNA expression under HFD conditions. PMID: 28479249
13. cadherin 2 (CDH2) and CDH4 cooperate to regulate radial migration in mouse brain via the protein tyrosine phosphatase 1B (PTP1B) and alpha- and beta-catenins. PMID: 27151949
14. this paper shows that PTP1B specifically regulates IgE-mediated STAT5 pathway, but is redundant in influencing mast cell function in vivo PMID: 27311921
15. PTP1B/RNF213/alpha-KGDD pathway is critical for survival of HER2(+) breast cancer, and possibly other malignancies, in the hypoxic tumour microenvironment PMID: 27323329
16. These findings reveal a novel role for pancreatic PTP1B in cerulein- and arginine-induced acute pancreatitis. PMID: 27461362
17. POMC-Ptp1b deletion increases plasma TNF-alpha levels PMID: 26935109
18. Taken together, the data presented here suggest that PTP1B is essential for proper differentiation of ES cells into cardiomyocytes. PMID: 27826746
19. This study demonstrates that PTP1B is an important positive regulator of neuroinflammation PMID: 27095436
20. Cudrania tricuspidata leaves (CTe) had a strong inhibitory effect on PTP1B activity and substantially inhibited fat accumulation in 3T3-L1 cells PMID: 26989693
21. Deletion of Ptp1b in POMC neurons protects from leptin- and sympatho-mediated increases in BP. PMID: 26523876
22. these data provide first evidence for a key regulatory role for PTP1B in mediating a central dendritic cells function of initiating adaptive immune responses in response to innate immune cell activation. PMID: 26063615
23. These findings indicated that improvement of insulin sensitivity and hypoglycemic effects of ME may be attributed to the inhibition of PTP1B. Thereby, we pioneered the inhibitory potential of ME targeted on PTP1B as anti-T2DM drug discovery. PMID: 26064877
24. This study presents PTP1B as a mechanism-based therapeutic target for RTT, validating a unique strategy for treating the disease by modifying signal transduction pathways with small-molecule drugs. PMID: 26214522
25. Studied the liver-specific role of PTP1B in GH signaling. PMID: 24948418
26. Fumosorinone increased glucose uptake and improved insulin resistance by down-regulating the expression of PTP1B and activating the insulin signaling pathway, suggesting that it may possess antidiabetic properties. PMID: 25796170
27. that PTP1B knockout offers cardioprotection against high fat diet intake through activation of AMPK. PMID: 25018087
28. PTP1B up-regulation in podocytes induces a migratory response by activating Src-family kinases and focal adhesion kinase, leading to foot process effacement and proteinuria PMID: 24951831
29. Complement-mediated glomerular injury is reduced by inhibition of protein-tyrosine phosphatase 1B. PMID: 25056348
30. results establish a novel role for PTP1B in regulating insulin action in the ventromedial hypothalamus PMID: 25083988
31. TRPV1 activation inhibited EGFR-induced epithelial cell proliferation via activation of Ca2+/calpain and resulting activation of protein tyrosine phosphatase 1B (PTP1B) PMID: 25083990
32. PTP1B modulates pancreatic beta-cell mass promoting beta-cell proliferation and reducing apoptosis. PMID: 24587334
33. High-fat feeding promoted earlier impairment of glucose tolerance and attenuated glucose-stimulated insulin secretion in PTP1B Knockout mice. PMID: 24956127
34. Results indicate that, although inhibition of PTP1B has potential benefits for the treatment of diabetes, it accentuates pro-inflammatory responses compromising at least macrophage viability. PMID: 24625984
35. PTP1B gene deletion protects against septic shock-induced cardiovascular dysfunction and mortality, and this may be the result of the profound reduction of cardiovascular inflammation. PMID: 24578383
36. IGF-1R positively regulates acute GH signaling by preventing access of PTP-1B activity to Janus kinase 2 and thereby preventing PTP-1B-mediated suppression of GH-induced STAT5 activation. PMID: 24030252
37. PTP1B level and activity were significantly higher in sperm from ob/ob mice than in wild-type littermates. PTP1B serves as a link between male obesity and infertility/subfertility. PMID: 24519936
38. deletion of PTP1B attenuates light stress-induced photoreceptor degeneration PMID: 24203758
39. PTP1B deficiency ameliorates murine experimental colitis via the expansion of myeloid-derived suppressor cells. PMID: 23951017
40. PTP1B is the first known tyrosine phosphatase for Munc18c and a regulator of its phosphorylation and function in adipocytes. PMID: 23937695
41. Detection of a PTP1b-dependent set of phosphosites on lipid-metabolic proteins motivated global lipidomic analyses that revealed altered polyunsaturated-fatty-acid (PUFA) and triglyceride metabolism in L-PTP1b(-/-) mice. PMID: 23685806
42. GPx-1-PTP1B-PP2A axis plays a critical role in countering the inflammatory and proteolytic responses that result in lung-tissue destruction in response to cigarette smoke exposure. PMID: 23590304
43. A role of PTP1B is in the regulation of SOCE in hippocampal neurons and evidence for tyrosine phosphorylation processes that follow intracellular ER Ca2+ store depletion. PMID: 23218930
44. Although loss of PTP1B enhances tyrosine phosphorylation of the IGF-IR in retinal explants of IRS2(-/-) mice, Akt activation remains defective owing to elevated PTEN levels and, thus, structural and functional visual defects persist in this model. PMID: 23702782
45. the metabolic basis to the pivotal role of PTP1B in liver regeneration PMID: 23246914
46. PTP1B negatively regulates adipocyte development and may mediate TNFalpha action to impair adipocyte differentiation in obesity. PMID: 23711960
47. These data demonstrate that PTP1B negatively regulates palmitate-induced cytokine secretion in macrophages by mechanisms involving the activation of MAPKs and NF-kB pathways PMID: 23229720
48. COP1 physically interacted with PTP1B and suppressed PTP1B phosphatase activity as well as the association of PTP1B with IRbeta. PMID: 23439647
49. PTP1B deficiency in the nonhematopoietic compartment or PTP1B deletion in endothelial cells blocks allergic lung inflammation. PMID: 23275627
50. It was shown that neuronal androgen receptors regulate hypothalamic insulin signaling by repressing NF-kappa B-mediated induction of protein-tyrosine phosphatase 1B. PMID: 23139353

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KEGG: mmu:19246

STRING: 10090.ENSMUSP00000029053

UniGene: Mm.277916