Recombinant Rat Pancreas/duodenum homeobox protein 1 (Pdx1)

1. Results found that Pdx-1 overexpression exerts its effects on islet cell replication via a noncell-autonomous mechanism involving induction of a secreted soluble factor or factors. Also, Inhbb is identified as one factor mediating the proliferative effect of Pdx-1. PMID: 27620967
2. restoring proteins in the diet after birth in low protein offspring dramatically impairs glucose homeostasis in early adulthood, by altering Pdx1 expression and downstream-target genes increasing the risk to develop type 2 diabetes. PMID: 25667428
3. These results suggest that a secreted luciferase reporter system in vivo enables not only the monitoring of promoter activity but also a quantitative and minimally invasive assessment of physiological and pathological changes in small cell masses. PMID: 24029239
4. It might promote both the proliferation and cytodifferentiation of small acinar cells and, thus, be closely related to acinar cell regeneration. PMID: 23123389
5. PASK phosphorylates and inactivates GSK3beta, thereby preventing PDX-1 serine phosphorylation and alleviating GSK3beta-mediated PDX-1 protein degradation in pancreatic beta-cells. PMID: 23853095
6. B-cell translocation gene 2 (BTG2) is a crucial regulator in GLP-1-induced insulin gene expression and insulin secretion via upregulation of pancreatic duodenal homeobox-1 (PDX-1) in pancreatic beta-cells. PMID: 23703573
7. a key role of PPARgamma in regulating pancreatic beta-cell function by improving the stability of Pdx1 and Mafa proteins PMID: 23424659
8. Triiodothyronine (T3) induces proinsulin gene expression by activating PI3K: possible roles for GSK-3beta and the transcriptional factor PDX-1. PMID: 23147208
9. Pdx1 expressing pancreatic progenitor cells preserve the viability and function of pancreatic islets. PMID: 22644623
10. The inhibitory effect of Urotensin IIon insulin secretion is associated with a suppression of GCK expression, not regulation of PDX-1 expression. PMID: 20401447
11. Nicotinamide mononucleotide can stimulate insulin secretion and upregulate the mRNA expression of PDX-1 in RIN-m5f cells. PMID: 22086006
12. Through multiple mechanisms, SREBP-1c, when induced in a lipotoxic state, repressed PDX-1 expression contributing to the inhibition of insulin expression and beta cell dysfunction. PMID: 21652712
13. PDX-1 and to a lesser extent other pancreatic transcription factors, could rapidly and specifically activate pancreatic lineage and beta-cell-like functional characteristics in ectoderm-derived human keratinocytes. PMID: 22028850
14. AGEs induced nuclear accumulation of Foxo1; this in turn reduced Pdx-1 expression by decreasing its protein stability, ultimately affecting insulin synthesis PMID: 21533167
15. IUGR rats that failed to undergo catch-up growth might be prone to abnormal glucose tolerance, decreases islet size, and increased PDX-1 mRNA in early adult life. PMID: 20626638
16. Pax6 is localized in the nucleus and prevents the activation of the insulin gene by occupying the PDX-1 binding site and by interacting with BETA2 PMID: 20943817
17. The purpose of this study was to confirm that the expression of Pdx1 could mediate the differentiation of rat mesenchymal stem cells (MSCs) into insulin-producing cells. PMID: 20306305
18. AMPK regulates the expression of PDX-1 at both the transcriptional and protein levels, and PPARalpha may be acutely involved in the regulation of INS-1 cells. PMID: 20644547
19. Roux-en-Y gastric bypass (RYGB) increases the expression of pancreatic PDX-1 and induces the regeneration of beta-cells. The associated regeneration of islet cells may be a possible mechanism that how RYGB could improve type 2 diabetes mellitus. PMID: 20458761
20. the PDX1 C terminus has a role in mediating the effects of glucose, which modulates PDX1 stability via the AKT-GSK3 axis PMID: 19833727
21. Data support the conclusion that the activation of Akt by ANP or 8-Br-cGMP promotes cyclin D2, PDX-1, and glucokinase transcription by phosphorylating and restricting Foxo1a activity. PMID: 19837876
22. Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin. PMID: 11978636
23. role in mediating GAD67 transcription in islets of Langerhans PMID: 12150938
24. loss of PDX1 function alters expression of mitochondrially encoded genes through regulation of TFAM leading to impaired insulin secretion PMID: 15151993
25. Pdx1 induces the expression of multiple genes related to endocrine pancreas development and islet function in these liver cells. PMID: 15561947
26. Beta cell maturation accompanied by increased IL-1beta sensitivity is, in part, dependent upon the expression of genes regulated by Pdx1. PMID: 15605246
27. prolonged exposure of pancreatic islets to palmitate inhibits insulin gene transcription by impairing nuclear localization of PDX-1 and cellular expression of MafA PMID: 15944145
28. Expression of PDX-1, a repressor of sucrase and lactase promoters, was 4.5-fold higher in iron deficiency in rats. PMID: 16081762
29. the pancreatic duodenal homeobox-1 protein is regulated by DNA-dependent protein kinase PMID: 16166097
30. Data show that FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. PMID: 16847327
31. pancreatic duodenal homeobox (PDX)-1 expression decreased with age in pancreatic tissue sections of rats. These data support the use of islets from older rats as a more appropriate model to study glucose-induced beta-cell apoptosis. PMID: 16936193
32. exogenous expression of Pdx-1 should provide a promising approach for efficiently producing islet-like cells from bone marrow mesenchymal stem cells for the future therapeutic use in diabetic patients PMID: 17172056
33. Expression in pancreatic beta cells is enhanced by peroxisome proliferator-activated receptor-gamma. PMID: 17192469
34. possible relationship between PDX-1 and the state of islet proliferation, islet-to-ductal transdifferentiation, apoptosis, and the expression of SSTRs PMID: 17583748
35. PDX-1 expression may have a role in proliferation of duct epithelial cells after partial pancreatectomy in rats PMID: 17690043
36. PDX-1 can differentiate rat pancreatic ductal epithelial cells into insulin-producing cells in vitro. In vitro PDX-1 transfection is a valuable strategy for increasing the source of insulin-producing cells. PMID: 17876894
37. The expression of PDX-1 mRNA in islet samples of different purity suggests the presence of stem cells in all islet samples. PMID: 17897921
38. progressive epigenetic silencing of Pdx1 has a role in development of type 2 diabetes following intrauterine growth retardation in rats PMID: 18464933
39. Small hepatocytes were transformed into both insulin- and glucagon-producing cells following ectopic Pdx-1 gene expression. Mature hepatocytes were transformed predominantly into glucagon-producing cells. PMID: 18670842
40. Data show that liver cells over-expressing Pdx-1 present interesting alterations concerning glucose metabolism. PMID: 18971862
41. KGF directly induces the expression of PDX1 in some ductal cells thus inducing beta-cell neogenesis PMID: 19266047
42. Chronic leucine might result in an increase in AMPK and then a decrease in PDX-l, in turn to depress GCK and GLUT2 resulting in decreased glucose-stimulated insulin secretion at high glucose and insulin content. PMID: 19438972
43. In high-fat diet throughout gestation neonates, immunoreactivity of Pdx-1 was significantly reduced PMID: 19604517
44. Insulin promoter factor 1 regulates transcription of mitochondrial DNA-encoded genes via regulation of mitochondrial factor A. PMID: 19656489

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KEGG: rno:29535

STRING: 10116.ENSRNOP00000066935

UniGene: Rn.54603