Code | CSB-RA015486A343phHU |
Size | US$210 |
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Application | Recommended Dilution |
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WB | 1:500-1:5000 |
The phospho-NBN (S343) recombinant monoclonal antibody is a highly specific antibody against the phosphorylated human NBN at Ser 343. This phospho-NBN (S343) antibody was expressed by transfecting the S343 phospho-NBN monoclonal antibody gene-vector clones into the cell line for in vitro production and subsequent purification from the tissue culture supernatant (TCS) through affinity-chromatography. Its isotype matches with the rabbit IgG. This anti-NBN-pS343 antibody can be used in ELISA and WB applications.
NBN is a part of the MRE11/RAD50/NBN complex, which is involved in the detection and repair of DNA double-strand breaks in the early stages. The Nijmegen breakage syndrome is caused by mutations in the NBN gene (NBS). ATM phosphorylation of NbN is required for some human cell responses to DNA damage. The central region of NBN has several SQ motifs that are phosphorylated by ATM. In particular, phosphorylation of serine residues S278 and S343 are required for intra-S phase checkpoint activation.
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