Nibrin is a protein in humans that is encoded by NBN gene. Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3/PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions.
The following NBN reagents supplied by CUSABIO are manufactured under a strict quality control system. Multiple applications have been validated and solid technical support is offered.
NBN Antibodies for Homo sapiens (Human)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA015486GA01HU | NBN Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA069758 | Phospho-NBN (Ser343) Antibody | Human | ELISA,WB |
CSB-PA985787 | NBN (Ab-343) Antibody | Human | ELISA,WB,IHC |
CSB-PA252258 | NBN Antibody | Human,Mouse,Rat | ELISA,WB |
CSB-PA003451 | NBN Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
CSB-PA020027 | Phospho-NBN (S343) Antibody | Human,Rat | WB, ELISA |
CSB-PA020028 | Phospho-NBN (S278) Antibody | Human | WB, IF, ELISA |
CSB-PA020029 | NBN Antibody | Human | WB, IHC, IF, ELISA |
CSB-PA020030 | NBN Antibody | Human,Rat | WB, IHC, ELISA |
CSB-PA170330 | NBN Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-PA229808 | NBN Antibody | Human,Mouse,Rat | ELISA,IHC |
CSB-RA015486A343phHU | Phospho-NBN (S343) Recombinant Monoclonal Antibody | Human | ELISA, WB |
NBN Antibodies for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Species Reactivity | Application |
---|---|---|---|
CSB-PA015486XA01DIL | nbn Antibody | Danio rerio (Zebrafish) (Brachydanio rerio) | ELISA, WB (ensure identification of antigen) |
NBN Proteins for Homo sapiens (Human)
Code | Product Name | Source |
---|---|---|
CSB-YP015486HU CSB-EP015486HU CSB-BP015486HU CSB-MP015486HU CSB-EP015486HU-B |
Recombinant Human Nibrin (NBN) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NBN Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)
Code | Product Name | Source |
---|---|---|
CSB-YP015486DIL CSB-EP015486DIL CSB-BP015486DIL CSB-MP015486DIL CSB-EP015486DIL-B |
Recombinant Danio rerio Nibrin (nbn), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NBN Proteins for Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii)
Code | Product Name | Source |
---|---|---|
CSB-YP015486PYX CSB-EP015486PYX CSB-BP015486PYX CSB-MP015486PYX CSB-EP015486PYX-B |
Recombinant Pongo abelii Nibrin (NBN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NBN Proteins for Gallus gallus (Chicken)
Code | Product Name | Source |
---|---|---|
CSB-YP015486CH CSB-EP015486CH CSB-BP015486CH CSB-MP015486CH CSB-EP015486CH-B |
Recombinant Chicken Nibrin (NBN), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NBN Proteins for Rattus norvegicus (Rat)
Code | Product Name | Source |
---|---|---|
CSB-YP015486RA CSB-EP015486RA CSB-BP015486RA CSB-MP015486RA CSB-EP015486RA-B |
Recombinant Rat Nibrin (Nbn) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
NBN Proteins for Mus musculus (Mouse)
Code | Product Name | Source |
---|---|---|
CSB-YP015486MO CSB-EP015486MO CSB-BP015486MO CSB-MP015486MO CSB-EP015486MO-B |
Recombinant Mouse Nibrin (Nbn) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |