Recombinant Mouse Bone morphogenetic protein receptor type-1A(Bmpr1a)

Code CSB-CF002748MO
Size Pls inquire other sizes
Source in vitro E.coli expression system
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Product Details

Target Names Bmpr1a
Uniprot No. P36895
Alternative Names Bmpr1a; Acvrlk3; BmprBone morphogenetic protein receptor type-1A; BMP type-1A receptor; BMPR-1A; EC; Activin receptor-like kinase 3; ALK-3; BMP-2/BMP-4 receptor; Serine/threonine-protein kinase receptor R5; SKR5; CD antigen CD292
Species Mus musculus (Mouse)
Expression Region 24-532
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal 10xHis-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction
Gene References into Functions
  1. we generated the transgenic mouse line with deletion of Tak1 and gain of function of Bmpr1a. This compound mutation leads to more severe craniofacial deformities than each single mutation. PMID: 29411501
  2. Data shows that 1) hepatocyte-specific Alk3 deficiency partly protects from anemia of inflammation (AI), 2) the development of hypoferremia is partly dependent on ALK3, and 3) the ALK3/BMP/hepcidin axis may serve as a possible therapeutic target to attenuate AI. PMID: 29482530
  3. Bmpr1a deletion transiently disrupted development of prenatal pancreatic islets and reduced expression of E-Cadherin. PMID: 28922976
  4. These studies emphasize the pivotal role of BMPR1A in the determination of bone quality and mechanical integrity under physiological conditions, with different impact on femoral cortical and trabecular compartments. PMID: 27113526
  5. loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL and SOST, leading to osteoclast inhibition and Wnt activation together. PMID: 27402532
  6. Data indicate the regulation of energy balance in BMPR1A-mediated appetite regulation in POMC neurons. PMID: 29040444
  7. findings suggest that GJA1 may be one of the downstream targets of BMPR1A signaling in osteoclasts that mediates osteoclast-osteoblast communication during bone remodeling. PMID: 27649478
  8. deletion of BMPR1a in oncogenic astrocytes resulted in decreased proliferation, decreased invasion, decreased migration, and increased expression of stemness markers PMID: 26683138
  9. different levels of expression and subsequent activation of Smad signaling differentially contribute each BMP type I receptor to BMP-Smad signaling and craniofacial development. PMID: 28641928
  10. BMP signaling mediated by coordination of ALK2/ACVR1, ALK3/BMPR1A, and BMPR2 is an essential proangiogenic cue for retinal vessels. PMID: 28232325
  11. Gonadotrope-specific Bmpr1a knockout animals developed normally and had reproductive organ weights comparable with those of controls. Knockouts were fertile, with normal serum gonadotropins and pituitary gonadotropin subunit mRNA expression. Cre-mediated recombination of the floxed Bmpr1a allele was efficient and specific, as indicated by PCR analysis of diverse tissues and isolated gonadotrope cells. PMID: 27029473
  12. CK2.1 peptide drives chondrogenesis and cartilage formation without induction of chondrocyte hypertrophy by releasing CK2 from distinct sites at BMPRIa PMID: 27312334
  13. These results suggest that Pax8 maybe the downstream molecule of ALK3, it mediates the murine heart development via cellular senescence, which may serve as a mechanism that compensates for the cell loss via apoptosis in heart development. PMID: 26781745
  14. Bmpr1aDeltaMES mice exhibited increased subepithelial proliferation with changes in cellular composition leading to the development of a primed stroma with modulation of extracellular matrix proteins, immune cells and cytokines as early as 90 days of age PMID: 26773796
  15. study suggested that Bmpr-Ia and Bmpr-Ib signaling regulates tooth formation via miR-135a. PMID: 24667771
  16. signaling via activin-like kinase 3 (ALK3/BMPR1A), a BMP type 1 receptor, is necessary for blastocyst attachment. PMID: 26721398
  17. Interactions between mechanical loading and BMP signaling through BMPR1A. PMID: 26489086
  18. Myo-endothelial progenitors with functioning Bmpr1a signalling demonstrate myogenic potential, but their main function in vivo is to inhibit intramuscular adipogenesis, both through a cell-autonomous and a cell-cell interaction mechanism. PMID: 24898859
  19. Bmpr1a is critical for the development and growth of the mandibular condyle via its effect on proliferation of prechondroblasts and chondrocyte differentiation PMID: 25158185
  20. BMP-Smad4 signaling is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse. PMID: 25641697
  21. An essential role of finely tuned BMPRIA mediated signaling in temporomandibular joint development. PMID: 25093411
  22. Alk3 mediated Bmp signaling is important in the cascade of events that regulate the contribution of EPDCs to the AV sulcus, annulus fibrosus, and the parietal leaflets of the AV valve PMID: 25300579
  23. Anti-Mullerian hormone recruits BMPR-IA in immature granulosa cells PMID: 24312319
  24. results provide evidence that HFE induces hepcidin expression via the BMP pathway: HFE interacts with ALK3 to stabilize ALK3 protein and increase ALK3 expression at the cell surface. PMID: 24904118
  25. Data indicate that epithelial-specific bone morphogenetic protein (Bmp) receptor 1a (Bmpr1a) conditional mutation leads to prostatic epithelial hyperplasia. PMID: 24731097
  26. Bmpr1a is involved in postnatal growth plate cell differentiation. PMID: 24163588
  27. FGFR3 induces degradation of Bmpr1a to regulate skeletal development. PMID: 24657641
  28. Data suggest BMP2 (bone morphogenetic protein 2) stimulates SMAD2/3 signaling in gonadotrophs via Bmpr1a activation; such signaling via SMAD3 appears to be necessary for up-regulation of Fshb (follicle stimulating hormone beta) transcription. PMID: 24601881
  29. The ability of IL-6 to induce hepatic hepcidin gene expression and reduce serum iron concentrations is dependent on the BMP type I receptor Alk3. PMID: 24501215
  30. BMPR1a and BMPR2 are downregulated in cardiac remodeling and heart failure PMID: 24398041
  31. Augmented BMPRIA-mediated BMP signaling in cranial neural crest lineage leads to cleft palate formation and delayed tooth differentiation. PMID: 23776616
  32. The effects of Alk3 knockout on tooth epithelial cells are dependent on the upregulation of the Wnt/beta-catenin pathway. PMID: 24081330
  33. BMPR1 signaling controls dendrite complexity postnatally during the major dendritic growth period of sympathetic neurons. PMID: 24048844
  34. This study demonistrated that BMP signaling has no major role in the development of excitatory and inhibitory synapses in the lateral superior olive. PMID: 23708139
  35. Perturbation of Alk3-mediated BMP signaling from the second heart field results in impaired development of the dorsal mesenchymal protrusion and ostium primum defects. PMID: 23584254
  36. These findings provide genetic evidence indicating that optimal Bmpr1a-mediated signaling is essential for neural crest-derived mesenchymal cell survival in both normal nasal and frontal bone development. PMID: 22773757
  37. These findings suggest that BMPR1A signaling is critical for postnatal establishment of leptin-responsive orexigenic fibers from ARH to multiple hypothalamic nuclei. PMID: 23197713
  38. ALK3 is the primary type I receptor recruited by the MIS-MISRII complex during Leydig cell differentiation. PMID: 22872577
  39. evidence functionally identifies BMPR1A as a potential new regulator of mammary epithelial alveolar cell differentiation PMID: 22729646
  40. BMPR1A fusion protein stimulates osteoblastic bone formation and decreases bone resorption, which leads to an increase in bone mass, and offers a promising unique alternative for the treatment of bone-related disorders. PMID: 22761317
  41. A regulatory mechanism of BMPRIa signaling at the plasma membrane of BMSCs. PMID: 22170575
  42. activin-like kinase 3 (Alk3) is elevated early in diseased kidneys after injury..its deletion leads to enhanced Smad3 signaling, epithelial damage and fibrosis, suggesting a protective role for Alk3-mediated signaling in the kidney PMID: 22306733
  43. These data suggest that in congenic 6T mice BMP receptor, including BMPR1a, aggregation is inhibited causing an inhibition of signaling and reduced bone mass. PMID: 22036911
  44. Mineralization was initiated with the overexpression of the BMPRIa mutants indicating CK2 is a negative regulatory protein for osteoblast differentiation PMID: 21763800
  45. results indicate that deletion of Bmpr1a in differentiated osteoclasts increases osteoblastic bone formation, thus suggesting that BMPR1A signaling in osteoclasts regulates coupling to osteoblasts by reducing bone-formation activity during bone remodeling PMID: 21786321
  46. This would be the first report showing that the mutation of the Bmpr1a gene in the bulbourethral gland (BUG) epithelia phenocopied some abnormalities of human congenital syndromes affecting the BUG duct PMID: 21848994
  47. Alk3, is critically responsible for basal hepcidin expression, whereas 2 type I BMP receptors, Alk2 and Alk3, are required for regulation of hepcidin gene expression in response to iron and BMP signaling. PMID: 21841161
  48. The results demonstrate a requirement for Alk3 in distinct progenitor cell populations derived from the intermediate mesoderm. PMID: 21613322
  49. JNK1 activation decreases binding of inhibitory Smad6 to the type I BMP receptor. PMID: 21542012
  50. A requirement for BMP signaling in patterning of dorsal neural tube cell fate and in neural crest cell formation, and a critical period shortly before neural tube closure. PMID: 21394823
  51. signaling through BMPR1A;B performs at least two roles in early respiratory development: first, it promotes tracheal formation through repression of Sox2; and second, it restricts the site of lung bud initiation. PMID: 21303850
  52. Expression of Msx1 and Fgf10 was downregulated in the anterior palate mesenchyme and expression of Shh was downregulated in the anterior palatal epithelium in the Bmpr1a conditional mutant embryos PMID: 21185278
  53. BmprIa is required in mesenchymal tissue and has limited redundant function with BmprIb in tooth and palate development. PMID: 21034733
  54. Deletion of Bmpr1a inhibits differentiation of the esophageal and forestomach epithelium. PMID: 21068065
  55. BMPRIA in osteoblasts negatively regulates endogenous bone mass and Wnt/beta-catenin signaling and that this regulation may be mediated by the activities of Sost and Dkk1 PMID: 19874086
  56. These studies support a role for a functional BMP signaling axis as a tumor suppressor pathway in the ovary, with BMPR1A and BMPR1B acting downstream of BMP ligands and upstream of BMP receptor SMADs. PMID: 20363875
  57. results indicate a requirement for BMP signaling in generating the dorsalmost neuronal lineage of the telencephalon, DG granule neurons, and development of the stem cell niche that makes neurons in the adult hippocampus. PMID: 20445055
  58. In embryos with an epiblast-specific deletion of Bmpr1a (Bmpr1a(null/flox); Sox2Cre embryos), the anterior visceral endoderm cells migrate randomly from the distal end of embryos, resulting in an expansion of the anterior visceral endoderm. PMID: 20211162
  59. Data found that the mice with ALK3 gene knock-out produced heart defects involving the interventricular septum. PMID: 15969004
  60. TbetaRIII specifically enhanced ALK3-mediated up-regulation of the early response gene ID-1. TbetaRIII associated with ALK3 primarily through their extracellular domains. PMID: 19726563
  61. BMPR1a and BMPR1b exert directly opposing effects on the initial reactive astrocytic hypertrophy in gliosis after spinal cord injury. PMID: 20130193
  62. ALK3 is essential, beyond just the egg cylinder stage, for myocyte-dependent functions and signals in cardiac organogenesis. PMID: 11854453
  63. Bmpr1a is a type I receptor for anti-Mullerian hormone-induced regression of Mullerian ducts PMID: 12368913
  64. BMP signalling through BMPRIA controls the number of hematopoietic stem cells by regulating niche size PMID: 14574412
  65. BMPR-1A, -2, and Noggin are upregulated in undifferentiated mesenchymal cells and regenerating muscle fibers occurs during the early phase of BMP-2-induced bone formation PMID: 14584896
  66. identification of Leu51 and Asp53 on bone morphogenetic protein 2 as receptor binding sites PMID: 15064755
  67. Data suggest that bone morphogenetic protein receptor IA is unnecessary for many aspects of early neural crest biology, but mutant embryos display a shortened cardiac outflow tract with defective septation, a process essential for perinatal viability. PMID: 15073157
  68. Type IA receptor for BMP signaling is required for osteoblast function and bone remodeling. PMID: 15090551
  69. Bmpr1a is required for completion of tooth morphogenesis, and regulates terminal differentiation and proliferation in postnatal hair follicles. PMID: 15102710
  70. BMPR-IA signaling plays critical and multiple roles in controlling cell fate decisions or maintenance, proliferation, and differentiation during hair morphogenesis and growth, and implicate Bmpr1a as a tumor suppressor in skin tumorigenesis PMID: 15124223
  71. Results suggest that bone morphogenetic protein (BMP) receptor IA signaling in the epiblast does not restrict cells to or from any of the germ layers, and reveal roles for BMP signaling in endodermal morphogenesis and ectodermal patterning. PMID: 15136140
  72. in mesenchymal progenitors bone morphogenetic protein receptor BMPR-IA is responsible for initiation of osteogenic as well as chondrogenic development and BMPR-IA and -IB receptor pathways are well separated during differentiation of mesenchymal lineages PMID: 15322331
  73. BMPR1a is not required for normal formation of joints in mice, but articular cartilage within the joints gradually wears away in receptor-deficient mice after birth in a process resembling human osteoarthritis PMID: 15492776
  74. BMP signaling through Bmpr is required for left-right patterning in the early mouse embryo. PMID: 15531373
  75. Bmpr1a and Bmpr1b play redundant roles during retinal development, and different threshold levels of Bmp signaling regulate distinct developmental programs such as patterning, growth and differentiation of the retina PMID: 15673568
  76. The fact that for both gdf5 family members the type I and type II receptor-binding sites interact suggests that the sites on the receptors may interact as well, suggesting how preformed receptor heterodimers may form. PMID: 15752764
  77. BMPR1A and BMPR1B are functionally redundant during early chondrogenesis and BMP signaling is required for chondrocyte proliferation, survival, and differentiation in vivo. PMID: 15781876
  78. roles for Alk3 signaling in the AV myocardium during the development of AV valves and the annulus fibrosus. PMID: 16037571
  79. Deletion of Bmpr1a in the epithelium with an Sftpc-cre transgene leads to dramatic defects in lung development. PMID: 16414041
  80. These results provide the first evidence of multiple type I and type II BMP-receptors, expressed in the dental epithelium and mesenchyme at different stages of development, to signal different cellular activities in a time- and tissue-specific way. PMID: 16432712
  81. Signaling plays a crucial role in the specification of granule cells during cerebellar development PMID: 16481421
  82. we show the existence of mRNA for BMP-2 and for the BMP receptors BMPR1A, BMPR1B, BMPRII, ACVR1A, ACVR2, and ACVR2B in differentiated mouse podocytes and the protein expression of BMPR1A in human glomerular podocytes. PMID: 16622178
  83. signaling through BMPR-IA in limb mesenchyme is essential for distal outgrowth and also influences body patterning PMID: 16630606
  84. Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation PMID: 16887829
  85. Alk3-mediated BMP signaling in AV endocardial/mesenchymal cells plays a central role during cushion morphogenesis PMID: 16959237
  86. When the Bmpr1a gene is conditionally ablated, otherwise quiescent stem cells are activated to proliferate, causing an expansion of the niche and loss of slow-cycling cells. PMID: 17553962
  87. Our finding suggests that Alk3 plays an essential role in the formation of embryonic ventral abdominal wall. PMID: 17588538
  88. BMPR1a mediates the suppressive effects of BMP signaling on oligodendrocyte lineage commitment and on the specification of calbindin-positive interneurons in the dorsomedial cortex. PMID: 17626200
  89. Epithelial Bmp (Bmpr1a) signaling plays an important role in the terminal differentiation of the intestinal secretory cell lineage but not in de novo crypt formation. PMID: 17678919
  90. BMP signaling through Bmpr1a suppresses tumorigenesis at gastric epithelial junctional zones that are distinct from the adjacent gastric epithelium in both cellular differentiation and proliferation. PMID: 17804727
  91. bone morphogenetic protein signaling is required in the myocardium of the AV canal for proper AV junction development, including the AV node. PMID: 17998461
  92. Smooth muscle protein 22alpha-mediated patchy deletion of Bmpr1a impairs cardiac contractility but protects against pulmonary vascular remodeling PMID: 18079409
  93. Mormal kidney development requires ALK3-dependent bone morphogenetic protein signaling, which controls ureteric bud branching. PMID: 18178801
  94. Deficiency of appropriate BMP signaling in lung epithelial cells results in prenatal lung malformation, neonatal atelectasis, and respiratory failure. PMID: 18258849
  95. Bmpr1a has two functions in the developing atrioventricular canal: to induce endocardial endothelial-mesenchymal transition, and to pattern the septal mesenchyme into endocardial cushions. PMID: 18498827
  96. BMPRIA signaling in astrocytes regulates the expression and level of vascular endothelial growth factor for proper cerebrovascular angiogenesis and has a role in the formation of the blood-brain-barrier. PMID: 18501628
  97. Data provided support that the ALK3 gene plays an important role during interventricular septum development. PMID: 18543407
  98. Loss of Bmpr1a, by decreasing MMP2 and/or MMP9 activity, can account for vascular dilatation and persistence of brain microvessels, leading to the impaired organogenesis documented in the brain. PMID: 18667463
  99. BMPRIA signaling in osteoblasts affects both bone formation and resorption to reduce endogenous bone mass in vivo PMID: 18684091
  100. BMPR1A is the preferred BMP2 type I receptor in LbetaT2 cells. PMID: 19211807

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Subcellular Location Membrane, Single-pass type I membrane protein
Protein Families Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
Tissue Specificity Widely expressed.
Database Links

KEGG: mmu:12166

STRING: 10090.ENSMUSP00000035900

UniGene: Mm.237825

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