Recombinant Human Interferon lambda-1 protein(IFNL1) (Active)

Code CSB-AP002811HU
Product Type Interferon
Size Pls inquiry other sizesPurchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q8IU54
Image
Storage Buffer 0.2 μm filtered PBS, pH 7.4 ,lyophilized
Alias IFN-lambda-1, Interleukin-29, IL-29
Species Homo sapiens (Human)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by an anti-viral assay using human HepG2 cells infected with encephalomyocarditis is less than 5 ng/ml, corresponding to a specific activity of >2.0x105 IU/mg.
Purity >97% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Sequence GPVPTSKPTT TGKGCHIGRF KSLSPQELAS FKKARDALEE SLKLKNWSCS SPVFPGNWDL RLLQVRERPV ALEAELALTL KVLEAAAGPA LEDVLDQPLH TLHHILSQLQ ACIQPQPTAG PRPRGRLHHW LHRLQEAPKK ESAGCLEASV TFNLFRLLTR DLKYVADGNL CLRTSTHPES T
Research Area Immunology
Source E.coli
Gene Names IFNL1
Expression Region 20-200aa
Product Info Tag-Free
Mol. Weight 19.8 kDa
Protein Description Full Length of Mature Protein
PubMed ID 12469119; 12483210; 15057824; 15489334; 20712453; 24751921; 20934432
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Function Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets
Subcellular Location Secreted
Protein Families Lambda interferon family
Database Links

HGNC: 18363

OMIM: 607403

KEGG: hsa:282618

STRING: 9606.ENSP00000329991

UniGene: Hs.406745

Pathway Jak-STAT signaling pathway

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