IP6K2 Antibody

1. An alpha-helical pair and a rare, two-turn 310 helix, that together form a substrate-binding pocket of IP6K2. PMID: 24956979
2. FGF2-signaling involves the inositol polyphosphate cascade, including inositol hexakisphosphate kinase (IP6K), and demonstrate that IP6K1,2 regulates Runx2 and osteoblast gene expression. PMID: 23322705
3. Genetic polymorphisms in IP6K2 gene is associated with autoimmune disease. PMID: 22446964
4. Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2. PMID: 21262846
5. Gene disruption of IP6K2 in colorectal cancer cells selectively impairs p53-mediated apoptosis, instead favoring cell-cycle arrest. IP6K2 acts by binding directly to p53 and decreasing expression of proarrest gene targets PMID: 21078964
6. IHPK2 over expression enhances sensitivity of ovarian carcinoma cells to radiation, IFN-beta, caspase 8 and DR4 PMID: 11896621
7. InsP6K2 is a physiologic mediator of cell death PMID: 15533939
8. IHPK2-TRAF2 binding leads to attenuation of TAK1- and NF-kappaB-mediated signaling and is partially responsible for the apoptotic activity of IHPK2. PMID: 17379600

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HGNC: 17313

OMIM: 606992

KEGG: hsa:51447

STRING: 9606.ENSP00000331103

UniGene: Hs.595983