IP6K2 Antibody

Datasheet

Code	CSB-PA109004
Size	US$297
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Image	Western blot analysis of extracts from HUVEC cells, Jurkat cells and COLO cells, using IP6K2 antibody. Immunofluorescence analysis of COS-7 cells, using IP6K2 antibody.
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) IP6K2 Polyclonal antibody

Uniprot No.

Q9UHH9

Target Names

IP6K2

Alternative Names

ATP 1D myo inositol hexakisphosphate phosphotransferase antibody; IHPK 2 antibody; IHPK2 antibody; Inositol hexakisphosphate kinase 2 antibody; InsP6 kinase 2 antibody; Ip6k2 antibody; IP6K2_HUMAN antibody; KIAA0263 antibody; OTTHUMP00000164824 antibody; P(i) uptake stimulator antibody; P(i)-uptake stimulator antibody; Pi uptake stimulator antibody; PiUS antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthesized peptide derived from internal of Human IP6K2.

Immunogen Species

Homo sapiens (Human)

Clonality

Polyclonal

Purification Method

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

It differs from different batches. Please contact us to confirm it.

Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Tested Applications

ELISA,WB,IF

Recommended Dilution

Application	Recommended Dilution
WB	1:500-1:3000
IF	1:100-1:500

Protocols

ELISA Protocol
Western Blotting(WB) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5).

Gene References into Functions

An alpha-helical pair and a rare, two-turn 310 helix, that together form a substrate-binding pocket of IP6K2. PMID: 24956979
FGF2-signaling involves the inositol polyphosphate cascade, including inositol hexakisphosphate kinase (IP6K), and demonstrate that IP6K1,2 regulates Runx2 and osteoblast gene expression. PMID: 23322705
Genetic polymorphisms in IP6K2 gene is associated with autoimmune disease. PMID: 22446964
Casein kinase-2 mediates cell survival through phosphorylation and degradation of inositol hexakisphosphate kinase-2. PMID: 21262846
Gene disruption of IP6K2 in colorectal cancer cells selectively impairs p53-mediated apoptosis, instead favoring cell-cycle arrest. IP6K2 acts by binding directly to p53 and decreasing expression of proarrest gene targets PMID: 21078964
IHPK2 over expression enhances sensitivity of ovarian carcinoma cells to radiation, IFN-beta, caspase 8 and DR4 PMID: 11896621
InsP6K2 is a physiologic mediator of cell death PMID: 15533939
IHPK2-TRAF2 binding leads to attenuation of TAK1- and NF-kappaB-mediated signaling and is partially responsible for the apoptotic activity of IHPK2. PMID: 17379600

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Subcellular Location

Nucleus.

Protein Families

Inositol phosphokinase (IPK) family

Database Links

HGNC: 17313

OMIM: 606992

KEGG: hsa:51447

STRING: 9606.ENSP00000331103

UniGene: Hs.595983

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Email: [email protected]
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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Related pathways

Phosphatidylinositol signaling system

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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