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Human C-C motif chemokine 14(CCL14) ELISA kit

Citations (1) Protocol MSDS
Code CSB-EL004777HU
Size 96T,5×96T,10×96T
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Product Details

Target Name
chemokine (C-C motif) ligand 14
Alternative Names
CC-1 ELISA Kit; CC-3 ELISA Kit; CCL14 ELISA Kit; CCL14_HUMAN ELISA Kit; chemokine (C-C motif) ligand 14 ELISA Kit; Chemokine CC-1/CC-3 ELISA Kit; chemokine CC1 ELISA Kit; chemokine CC3 ELISA Kit; chemokine HCC1 ELISA Kit; chemokine HCC3 ELISA Kit; CKb1 ELISA Kit; HCC 1 ELISA Kit; HCC 3 ELISA Kit; HCC-1(1-74) ELISA Kit; HCC-1(9-74) ELISA Kit; HCC-1/HCC-3 ELISA Kit; HCC-3 ELISA Kit; HCC1 ELISA Kit; HEMOFILTRATE CC CHEMOKINE 1 ELISA Kit; MCIF ELISA Kit; NCC-2 ELISA Kit; NCC2 ELISA Kit; new CC chemokine 2 ELISA Kit; SCYA14 ELISA Kit; SCYL2 ELISA Kit; small inducible cytokine subfamily A (Cys-Cys); member 14 ELISA Kit; Small-inducible cytokine A14 ELISA Kit; SY14 ELISA Kit
Abbreviation
CCL14
Uniprot No.
Q16627
Species
Homo sapiens (Human)
Sample Types
serum, plasma, tissue homogenates
Detection Range
0.156 ng/mL-10 ng/mL
Sensitivity
0.039 ng/mL
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Immunology
Assay Principle
quantitative
Measurement
Sandwich
ELISA Data Analysis
ELISA Standard Curve & Curve Expert software
Troubleshooting
and FAQs
ELISA kit FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx
Description

This human CCL14 ELISA kit employs the quantitative sandwich enzyme immunoassay technique to measure the levels of human CCL14 in multiple samples, including serum, plasma, or tissue homogenates. It also uses the enzyme-substrate chromogenic reaction to visualize and analyze the analyte levels through the color intensity. The intensity of the colored product is in direct proportion to the CCL14 levels in the sample and is measured at 450 nm through a microplate reader.

CCL14, also known as HCC-1, is found in high concentrations in blood plasma and acts as an inflammatory chemokine after N-terminus cleavage. It promotes the chemotaxis of monocytes, eosinophils, and T lymphoblasts. CCL14 specifically binds to CCR1, CCR3, and CCR5 to exert biological effects. CCL14 plays a dual role in the occurrence and development of cancer. A study showed that CCL14 inhibited the proliferation and invasion of colon cancer cells by impeding the formation of M2-like tumor-associated macrophages (TAMs). CCL14 was downregulated in several human cancers, including hepatocellular carcinoma (HCC). CCL14 expression in HCC tissues correlated with prognosis. Low CCL14 expression is linked to poorer overall survival, disease-specific survival, progression-free survival, and relapse-free survival in multiple cohorts of HCC patients, particularly at early disease stages.

Citations

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Target Background

Function
(From Uniprot)
Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.
Gene References into Functions
  1. TMEM88, CCL14, and CLEC3B genes were stable and available in predicting the survival and palindromia time of hepatocellular carcinoma. These genes could function as potential prognostic genes contributing to improve patients' outcomes and survival PMID: 28718365
  2. CCL14 is a critical mediator of the JARID1B/LSD1/NuRD complex in regulation of angiogenesis and metastasis in breast cancer. PMID: 21937684
  3. enhanced expression in intestinal epithelium in inflammatory bowel disease and display of antibacterial activity PMID: 19812544
  4. Functional data from activity assays by intracellular calcium flux and inhibition of CCR5-mediated HIV-1 entry show that only CCL14 [9-74] is fully active at these near-physiological concentrations where CCL14 [9-74] is monomeric and CCL14 is dimeric PMID: 17691823
  5. CCL14 is involved in mechanisms by which trophoblast cells migrate during early pregnancy. PMID: 18367676
  6. SLE, this study reveals strong associations with a marker and a haplotype encompassing the CCL14 gene, which suggests that a lupus relevant variant may lie within or in the proximity of this haplotype. PMID: 18602166
  7. the activity of CCL14a might be regulated by stringent proteolytic activation and inactivation steps PMID: 19553544
  8. D6 cooperates with CD26 in the negative regulation of CCL14 by the selective degradation of its biologically active isoform. PMID: 19632987

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Subcellular Location
Secreted.
Protein Families
Intercrine beta (chemokine CC) family
Tissue Specificity
Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.
Database Links

HGNC: 10612

OMIM: 601392

KEGG: hsa:6358

UniGene: Hs.272493

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