Name: CCL14 Antibody
Brand: CUSABIO
SKU: CSB-PA08947A0Rb

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) CCL14 Polyclonal antibody

Uniprot No.

Q16627

Target Names

CCL14

Alternative Names

CC-1 antibody; CC-3 antibody; CCL14 antibody; CCL14_HUMAN antibody; chemokine (C-C motif) ligand 14 antibody; Chemokine CC-1/CC-3 antibody; chemokine CC1 antibody; chemokine CC3 antibody; chemokine HCC1 antibody; chemokine HCC3 antibody; CKb1 antibody; HCC 1 antibody; HCC 3 antibody; HCC-1(1-74) antibody; HCC-1(9-74) antibody; HCC-1/HCC-3 antibody; HCC-3 antibody; HCC1 antibody; HEMOFILTRATE CC CHEMOKINE 1 antibody; MCIF antibody; NCC-2 antibody; NCC2 antibody; new CC chemokine 2 antibody; SCYA14 antibody; SCYL2 antibody; small inducible cytokine subfamily A (Cys-Cys); member 14 antibody; Small-inducible cytokine A14 antibody; SY14 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human C-C motif chemokine 14 protein (20-93AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The CCL14 Antibody (Product code: CSB-PA08947A0Rb) is Non-conjugated. For CCL14 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA08947B0Rb	CCL14 Antibody, HRP conjugated	ELISA
FITC	CSB-PA08947C0Rb	CCL14 Antibody, FITC conjugated
Biotin	CSB-PA08947D0Rb	CCL14 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5.

Gene References into Functions

TMEM88, CCL14, and CLEC3B genes were stable and available in predicting the survival and palindromia time of hepatocellular carcinoma. These genes could function as potential prognostic genes contributing to improve patients' outcomes and survival PMID: 28718365
CCL14 is a critical mediator of the JARID1B/LSD1/NuRD complex in regulation of angiogenesis and metastasis in breast cancer. PMID: 21937684
enhanced expression in intestinal epithelium in inflammatory bowel disease and display of antibacterial activity PMID: 19812544
Functional data from activity assays by intracellular calcium flux and inhibition of CCR5-mediated HIV-1 entry show that only CCL14 [9-74] is fully active at these near-physiological concentrations where CCL14 [9-74] is monomeric and CCL14 is dimeric PMID: 17691823
CCL14 is involved in mechanisms by which trophoblast cells migrate during early pregnancy. PMID: 18367676
SLE, this study reveals strong associations with a marker and a haplotype encompassing the CCL14 gene, which suggests that a lupus relevant variant may lie within or in the proximity of this haplotype. PMID: 18602166
the activity of CCL14a might be regulated by stringent proteolytic activation and inactivation steps PMID: 19553544
D6 cooperates with CD26 in the negative regulation of CCL14 by the selective degradation of its biologically active isoform. PMID: 19632987

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Subcellular Location

Secreted.

Protein Families

Intercrine beta (chemokine CC) family

Tissue Specificity

Expressed constitutively in several normal tissues: spleen, liver, skeletal and heart muscle, gut, and bone marrow, present at high concentrations (1-80 nM) in plasma.

Database Links

HGNC: 10612

OMIM: 601392

KEGG: hsa:6358

UniGene: Hs.272493

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Code	CSB-PA08947A0Rb
Size	US$166
Image	Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA08947A0Rb at dilution of 1:100
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CCL14 Antibody

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