Mouse Tumor necrosis factor ligand superfamily member 4(TNFSF4) ELISA kit

Code CSB-EL023994MO
Size 96T,5×96T,10×96T
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Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now

Product Details

Target Name
tumor necrosis factor (ligand) superfamily, member 4
Alternative Names
Tnfsf4; Ox40l; Txgp1l; Tumor necrosis factor ligand superfamily member 4; OX40 ligand; OX40L; CD antigen CD252
Uniprot No.
Mus musculus (Mouse)
Sample Types
serum, plasma, cell culture supernates, tissue homogenates
Detection Range
3.9 pg/mL
Assay Time
Sample Volume
Detection Wavelength
450 nm
Research Area
Assay Principle
and FAQs
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

This Mouse TNFSF4 ELISA Kit was designed for the quantitative measurement of Mouse TNFSF4 protein in serum, plasma, cell culture supernates, tissue homogenates. It is a Sandwich ELISA kit, its detection range is 15.6pg/mL-1000pg/mL and the sensitivity is 3.9 pg/mL.

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Target Background

(From Uniprot)
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
Gene References into Functions
  1. these findings demonstrate the utility of soluble OX40 L and JAG1 to induce TCR-independent regulatory T-cells proliferation PMID: 28045060
  2. The OX40L expression is induced on the bronchiolar progenitors for the antiviral immunity during the infectious process. However, these defense-like host responses lead to more extensive infection with the influenza virus owing to the induced OX40L with alpha-2,6 sialic acid modification, which augments the interaction with the viral hemagglutinin. PMID: 26976612
  3. Rhinovirus infection interferes with induction of tolerance to aeroantigens through OX40 ligand, thymic stromal lymphopoietin, and IL-33 PMID: 26100084
  4. intestinal Th2 priming is initiated by an autocrine/paracrine acting CD4(+) Th cell-intrinsic IL-4 program that is controlled by DC OX40L, and not by NKT, gammadelta T, or ILC cells. PMID: 24781052
  5. a critical role of OX40L presented by the activated basophils to initiate Th2 responses in an allergic asthma model, implicating OX40-OX40L signaling as a potential therapeutic target in the treatment of allergic airway inflammation. PMID: 25839234
  6. The majority of transferred CD40L(-/-) T cells in Rag-1(-/-) B6 mice were differentiated to CD44(high). PMID: 24254032
  7. The need for additional immune suppression in the intestine reflects commensal microbe-driven T-cell activation through the accessory costimulation molecules ICOSL and OX40L in B7 deprived mice. PMID: 25002484
  8. we identify a previously unknown role for OX40L in steady-state bone homeostasis PMID: 24469824
  9. Data indicate that OX40L contributes to both the development of Th2 cells and secondary Th2 responses induced by KLH-pulsed CD8- cDCs in vivo. PMID: 24462862
  10. These results showed a critical role for OX40L- and Jagged1-induced cosignaling in GM-BMDC-induced Treg expansion. PMID: 23630352
  11. engagement of OX40L selectively suppresses Fyn-initiated signals required for MC degranulation and serves to limit immediate hypersensitivity PMID: 22564682
  12. Present findings suggest a role for the OX40L-derived immune response and epistatic genetic effect in immune-mediated pathogenesis of PAH. PMID: 22171643
  13. The vascular OX40/OX40L system plays an important role in the formation of vasa vasorum and subsequent atherosclerosis. PMID: 20584752
  14. our data provide an in vivo role for the OX40/OX40L system in the innate immune response during polymicrobial sepsis PMID: 20844189
  15. Tumor necrosis factor ligand OX40L-expressing Langerhans cells play a mandatory role in the induction of regulatory T cells in ultraviolet B immunosuppressed mice. PMID: 20400709
  16. Constitutive interaction of OX40 ligand with OX40 during immune regulation is linked to the development of autoimmune-like diseases in OX40L-transgenic mice. PMID: 12370402
  17. Costimulation via OX40L expressed by B cells is sufficient to determine the extent of primary CD4 cell expansion and Th2 cytokine secretion. PMID: 12668647
  18. Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma. PMID: 12672051
  19. Engagement of OX40 by an OX40L:Ig fusion protein drives IFN-gamma production by CD4+ T cells and reduces eosinophilia and the burden of Cryptococcus neoformans in the lung. PMID: 12794142
  20. A null allele at OX40L completely prevents diabetes development in nonobese diabetic mice and strongly reduces its incidence in a T cell receptor transgenic model, while paradoxically sustaining the long-term progression to autoimmune destruction. PMID: 14662903
  21. OX40-OX40L interaction affects both regulatory and nonregulatory T cells by influencing suppression, susceptibility to suppression, and clonal expansion. PMID: 15004159
  22. OX40 and OX40L interactions form a late checkpoint in diabetes development and are realistic targets for therapeutic intervention. PMID: 15368274
  23. neonatal CD4+ CD3- cells up-regulate both CD30L and OX40L after adoptive transfer into an adult recipient PMID: 16920944
  24. OX40 ligand (OX40L) is required for optimal T helper (Th) type 2 cell priming and memory Th2 responses in vivo; dependence upon OX40L is predominantly due to the provision of signaling through OX40 rather than retrograde signaling dendritic cells. PMID: 17785785
  25. These results show a critical role for OX40L on DCs, via binding to OX40 on NKT cells and CD4+ T cells, in the induction of antitumor immunity in tumor-bearing mice. PMID: 17975668
  26. OX40 ligand (OX40L) is a critical in vivo mediator of TSLP-mediated Th2 responses. PMID: 18060034
  27. Th2 skewing is mediated by OX40L PMID: 18354165
  28. TNFSF4 gene is identified as a potential candidate Sjogren's syndrome susceptibility gene. PMID: 19032782
  29. OX40L may play an important role in the early phase of T cell activation and proliferation PMID: 19663699

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Subcellular Location
Membrane; Single-pass type II membrane protein.
Protein Families
Tumor necrosis factor family
Database Links
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