Mouse Tumor necrosis factor receptor superfamily member 13B(TNFRSF13B) ELISA kit

Code CSB-EL023971MO
Size 96T,5×96T,10×96T
Price Request a Quote or Start an on-line Chat
Trial Size 24T ELISA Kit Trial Size (Only USD$150/ kit)
* The sample kit cost can be deducted from your subsequent orders of 96T full size kits of the same analyte at 1/5 per kit, until depleted in 6 months. Apply now

Product Details

Alternative Names
Tnfrsf13b ELISA Kit; Taci ELISA Kit; Tumor necrosis factor receptor superfamily member 13B ELISA Kit; Transmembrane activator and CAML interactor ELISA Kit; CD antigen CD267 ELISA Kit
Abbreviation
TNFRSF13B
Uniprot No.
Species
Mus musculus (Mouse)
Sample Types
serum, plasma, tissue homogenates
Detection Range
78 pg/ml - 5000 pg/ml
Sensitivity
19.5 pg/ml
Assay Time
1-5h
Sample Volume
50-100ul
Detection Wavelength
450 nm
Research Area
Immunology
Assay Principle
quantitative
Measurement
Sandwich
Troubleshooting
and FAQs
Storage
Store at 2-8°C. Please refer to protocol.
Lead Time
3-5 working days after you place the order, and it takes another 3-5 days for delivery via DHL or FedEx

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Target Background

Function
(From Uniprot)
Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.
Gene References into Functions
  1. Data (including data from studies in knockout mice and cells from such mice) suggest that Taci in peritoneal and adipose tissue macrophages is involved in regulation of adipogenesis leading to obesity. PMID: 29871859
  2. results suggest that TACI A181E heterozygosity results in TACI haploinsufficiency with increased susceptibility to pneumococcal infection PMID: 27609654
  3. this study shows that increased TACI expression in B cells derived from non-obese diabetic mice contributes to the pathogenesis of type 1 diabetes NOD mice PMID: 27444337
  4. splenic B cells from TACI-deficient (TACI- / -) mice were unable to secrete IL-10 following TLR stimulation, and TACI- / - mice had undetectable basal serum concentrations of IL-10. PMID: 26139429
  5. Taci (-/-) mice and BAFF transgenic mice both develop signs of human Systemic Lupus Erythematosus. PMID: 25866827
  6. Elimination of B lymphocyte stimulator receptor 3 (BR-3) and TACI inhibits the development of SLE in NZM mice. PMID: 25989238
  7. TACI deficiency has a role in alternatively activated macrophage phenotype and susceptibility to Leishmania infection PMID: 26170307
  8. The released sTACI is an immunoregulator that shares decoy functions with atacicept. It reflects systemic and compartmentalized B cell accumulation and activation. PMID: 25505277
  9. Mice lacking TACI are able to clear Citrobacter rodentium, a model pathogen for severe human enteritis, more rapidly than did wild type mice. PMID: 25271628
  10. reduced TACI expression is responsible for the unresponsiveness of XID mouse to TI-2 Ags and BCR activation controls TACI expression. PMID: 24646744
  11. TACI is dispensable for the development of SLE in NZM mice. BAFF-TACI interactions contribute to SLE. PMID: 23334904
  12. TACI promotes sustained Blimp-1 expression by B cells responding to antigen, which in turn limits B-cell clonal expansion and facilitates differentiation of long-lived antibody-secreting cells. PMID: 21984806
  13. Mice deficient in TACI, a receptor for BLyS and APRIL, mounted an initial antiviral B cell response similar to that generated in WT mice but failed to sustain protective Ab titers. PMID: 21881204
  14. The C76R TACI mutation disrupts B cell function with lymphoproliferation and immunoglobulin production defects. PMID: 21458042
  15. MyD88 controls a B cell-intrinsic, TIR-independent, TACI-dependent pathway for immunoglobulin diversification PMID: 20676093
  16. Loss of TACI causes fatal lymphoproliferation and autoimmunity, establishing TACI as an inhibitory BLyS receptor. PMID: 12594954
  17. TACI and BAFF-R are able to transduce signals that result in isotype switching in B cells. PMID: 15630136
  18. Review. Short-lived antibody forming cell populations and their proliferating progenitors express a TACI-predominant signature. PMID: 16919470
  19. This review defines the exact contribution of TACI receptor stimulation by specific triggers in vitro, enabling us to better understand the complex, context-dependent responses initiated by TACI in vivo. PMID: 17171762
  20. Data suggest a novel role for TACI in anti-chromatin B cell homeostasis and differentiation. PMID: 17369193
  21. Our findings corroborate the notion that B cell deviations contribute to type 1 diabetes development, and suggest a temporal regulation of TACI(high) expression, possibly influenced by the ongoing autoimmune process. PMID: 17656068
  22. TACI has dual B cell-autonomous functions, inhibiting prolonged B cell proliferation and stimulating plasma cell differentiation PMID: 17675489
  23. A review of TACI function including regulation of B cell function. PMID: 18514565
  24. findings demonstrate that low TACI expression may be a critical factor that determines the susceptibility of newborns to infections with encapsulated bacteria and the impaired immunogenicity of polysaccharide vaccines PMID: 18606649
  25. mTACI A144E mutation and its human counterpart, A181E, disrupt TACI signaling and impair TACI-dependent B-cell functions. PMID: 19605846

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Subcellular Location
Membrane; Single-pass type III membrane protein.
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