Rat Platelet-Derived Growth Factor A,PDGF-A ELISA kit

Code CSB-E14313r
Size 96T,5×96T,10×96T
Trial Size 24T ELISA kits trial application
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Product Details

Alternative Names
Pdgfa ELISA Kit; Rpa1 ELISA Kit; Platelet-derived growth factor subunit A ELISA Kit; PDGF subunit A ELISA Kit; PDGF-1 ELISA Kit; Platelet-derived growth factor A chain ELISA Kit; Platelet-derived growth factor alpha polypeptide ELISA Kit
Abbreviation PDGFA
Uniprot No. P28576
Species Rattus norvegicus (Rat)
Sample Types serum, plasma, tissue homogenates
Detection Range 31.25pg/ml-2000pg/ml
Sensitivity 7.8 pg/ml
Assay Time 1-5h
Sample Volume 50-100ul
Detection Wavelength 450 nm
Research Area Cancer
Assay Principle quantitative
Measurement Sandwich
ELISA Data Analysis Watch ELISA data processing video & download Curve Expert if needed
Troubleshooting
and FAQs
ELISA kit FAQs
Storage Store at 2-8°C. Please refer to protocol.
Lead Time 3-5 working days

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Target Background

Function
(From Uniprot)
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB.
Gene References into Functions
  1. an Ntv-a transgenic rat colony was established and used to study glial brain tumors driven by two well-characterized oncogenic gene transformations, PDGFA overexpression and p53 depletion. Combined PDGFA and p53 alterations resulted in large, heterogeneous tumors in all affected animals PMID: 28358926
  2. Combined inhibition of PGDF and VEGF with sunitinib prevents chronic rejection changes in experimental kidney transplantation. PMID: 26262503
  3. expression altered in experimental Necrotizing enterocolitis PMID: 25899145
  4. PDGF regulates vascular smooth muscle phenotype via mammalian target of rapamycin complex 1. PMID: 26032503
  5. Replacing heregulin, PDGF-AA and bFGF with T3 for 6 days resulted in repression of O4, O1, Olig2 and PDGFR-a PMID: 25200619
  6. observations indicated that PDGF can contribute to the development of cardiac interstitial fibrosis in the noninfarcted myocardium, but does not alter scar formation in the infarcted myocardium. PMID: 25148874
  7. We detected the expression and levels of PDGF-AA, bFGF and IGF-1 in neuroblastoma cells and in conditioned media which stimulated proliferation of oligodendrocyte precursor cells. PMID: 22922759
  8. PDGF-AA contained in B104 neuroblastoma cells is a key regulating molecule that instructs oligodendrocyte differentiation from embryonic stem cells through activation of Erk, PI3K, and p38 signal pathway in vitro. PMID: 21953009
  9. Rad is regulated by PDGF through the transcriptional factor Egr-1 in RASMCs PMID: 21559360
  10. Paraquat-treated rats showed enhanced gene expression of growth factors such as platelet-derived growth factor-A and insulin-like growth factor-1 at 21 days and transforming growth factor-beta 1 at 14 days. PMID: 20498031
  11. The influence of physical exercise on the generation of PDGF-AA, in adipose tissue PMID: 20972576
  12. NF-kappaB modulates the expression of PDGF-a and PDGF-B in rat retina induced by IL-1beta. PMID: 17442164
  13. LPS exacerbates MWCNT-induced lung fibrosis by amplifying production of PDGF-AA in macrophages and epithelial cells, and by increasing PDGF-Ralpha on pulmonary fibroblasts PMID: 19738159
  14. the PDGF/PDGF receptor system is expressed in pituitary folliculostellate cells and is involved in VEGF regulation. PMID: 19373754
  15. platelet-derived growth factor-A and -B are stimulated by sphingosine 1-phosphate through S1P1-Gi-Ras-MAPK-dependent induction of Kruppel-like factor 5 PMID: 14711826
  16. NHERF2 stimulates PDGF-induced proliferation by increasing PI-3-kinase/Akt, MEKindependent ERK, and Src family kinase-mediated signaling pathways PMID: 15115658
  17. analysis of expression of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells PMID: 16039137
  18. the significance of the first expression of PDGF-A in the Leydig progenitor cells may be associated with inducing cell proliferation and migration of this cell away from the peritubular region during Leydig cell differentiation PMID: 16977580
  19. These results suggest that the neurotrophic effect of platelet-derived growth factor is mediated in part via upregulation of the expression and release of secreted amyloid precursor protein alpha. PMID: 17632272
  20. the inflammatory response associated with spinal cord injury in cutaneous wound healing resulted in no change in expression of platelet-derived growth factor-A at the wound site in injured rats compared to the control group PMID: 18428026
  21. PDGF-A may act to mobilize oligodendrocyte progenitor cells that then respond to distinct directional signals to distribute appropriately within the CNS. PMID: 18512152
  22. PTH-induced bone marrow fibrosis is mediated by PDGF-A via a phosphoinositide 3-kinase-dependent signaling pathway. PMID: 18635661
  23. PDGFR (platelet derived growth factor receptor)-alpha mRNA Is Upregulated in Acutely-Rejecting, and PDGF-A and PDGF-C mRNAis upregulated in Chronically-Rejecting Cardiac Allografts PMID: 19213942
  24. Report effects of lipopolysaccharide on platelet-derived growth factor isoform and receptor expression in cultured rat common bile duct fibroblasts and cholangiocytes. PMID: 19691150

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Subcellular Location Secreted.
Protein Families PDGF/VEGF growth factor family
Database Links

KEGG: rno:25266

STRING: 10116.ENSRNOP00000001775

UniGene: Rn.10999

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