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Recombinant Human IL23A & IL12B Heterodimer Protein (Active)

Recombinant Human IL23A & IL12B Heterodimer Protein (Active)

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Code	CSB-AP004661HU
Abbreviation	Recombinant Human IL23A&IL12B Heterodimer protein (Active)
MSDS	MSDS Datasheet
Size	$290
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Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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Product Details

Purity

Greater than 95% as determined by SDS-PAGE.

Endotoxin

Less than 1.0 EU/μg as determined by LAL method.

Activity

The ED50 as determined by its ability to induce STAT reporter activity in 293F human embryonic kidney cells is 70-210 ng/ml.

Target Names

IL23A

Uniprot No.

Q9NPF7&P29460

Research Area

Immunology

Alternative Names

IL 23 A; IL 23; IL 23 subunit alpha; IL 23A; IL 23p19; IL-23 subunit alpha; IL-23-A; IL-23p19; IL12B; IL23; Il23a; IL23A_HUMAN; IL23P19; interleukin 12B; Interleukin 23 alpha subunit p19; Interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23 subunit p19; interleukin six; G CSF related factor; Interleukin-23 subunit alpha; Interleukin-23 subunit p19; JKA3 induced upon T cell activation; MGC79388; P19; SGRF

Species

Homo sapiens (Human)

Source

Mammalian cell

Expression Region

20-189aa & 23-328aa

Complete Sequence

RAVPGGSSPAWTQCQQLSQKLCTLAWSAHPLVGHMDLREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEKLLGSDIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGAATLSP & IWELKKDVYVVELDWYPDAPGEMVVLTCDTPEEDGITWTLDQSSEVLGSGKTLTIQVKEFGDAGQYTCHKGGEVLSHSLLLLHKKEDGIWSTDILKDQKEPKNKTFLRCEAKNYSGRFTCWWLTTISTDLTFSVKSSRGSSDPQGVTCGAATLSAERVRGDNKEYEYSVECQEDSACPAAEESLPIEVMVDAVHKLKYENYTSSFFIRDIIKPDPPKNLQLKPLKNSRQVEVSWEYPDTWSTPHSYFSLTFCVQVQGKSKREKKDRVFTDKTSATVICRKNASISVRAQDRYYSSSWSEWASVPCS

Mol. Weight

19.5kDa&35.5kDa

Protein Length

Heterodimer

Tag Info

C-terminal 6xHis-tagged

Form

Liquid or Lyophilized powder

Buffer

Lyophilized from a 0.2 μm filtered 20mM PB, 200mM Trehalose, 4% Mannitol, 50mM NaCl, 0.02% Tween80, pH7.5.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.

Datasheet & COA

Please contact us to get it.

Description

IL-23 drives Th17 differentiation and sustains inflammatory responses, making it a critical target in autoimmune and tumor immunology research. This recombinant human IL-23 heterodimer (IL-23A aa 20–189 paired with IL-12B aa 23–328) demonstrates confirmed signaling potency with an ED50 of 70–210 ng/mL in a STAT reporter assay using 293F cells, supporting JAK/STAT pathway studies, Th17 polarization assays, and functional screening in antibody development campaigns. The C-terminal 6×His tag enables straightforward purification and oriented immobilization for use as a coating antigen in ELISA or as a reference standard in cytokine detection platforms. Mammalian-expressed to preserve native folding and post-translational modifications, this heterodimer provides greater than 95% purity and endotoxin levels below 1.0 EU/μg, satisfying the stringent criteria required to prevent LPS-driven artifacts in primary immune cell activation and in vivo inflammation models.