Recombinant Human Interleukin-23(IL-23) (Active)

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Code CSB-AP004661HU
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Product Details

Purity Greater than 95% as determined by SDS-PAGE.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Activity The ED50 as determined by its ability to binding IL23RA used funtional ELISA is less than 20 ug/ml
Target Names IL-23
Uniprot No. Q9NPF7
Research Area Immunology
Alternative Names IL 23 A; IL 23; IL 23 subunit alpha; IL 23A; IL 23p19; IL-23 subunit alpha; IL-23-A; IL-23p19; IL12B; IL23; Il23a; IL23A_HUMAN; IL23P19; interleukin 12B; Interleukin 23 alpha subunit p19; Interleukin 23 p19 subunit; interleukin 23 subunit alpha; interleukin 23 subunit p19; interleukin six; G CSF related factor; Interleukin-23 subunit alpha; Interleukin-23 subunit p19; JKA3 induced upon T cell activation; MGC79388; P19; SGRF
Species Homo sapiens (Human)
Source Mammalian cell
Expression Region 20-189aa & 23-328aa
Mol. Weight 54.4 kDa
Protein Length Heterodimer
Tag Info C-terminal 6xHis-tagged
Form Lyophilized powder
Buffer Lyophilized from a 0.2 μm filtered 1xPBS, pH 7.4
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Basically, we can dispatch the products out in 5-10 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet & COA Please contact us to get it.

Target Data

Function Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Gene References into Functions
  1. IL23 and IL17 have roles in the pathogenesis of Tunisian pemphigus foliaceus PMID: 30116153
  2. Effect of polymorphisms in IL-12B p40, IL-17A and IL-23 A/G genes on the response of psoriatic patients to narrowband UVB. PMID: 29763989
  3. Epigenetic control of IL-23 expression in keratinocytes is important for chronic skin inflammation. PMID: 29650963
  4. IL-23 binding to its receptor promotes the migration and invasion of gastric cancer cells by inducing epithelial-to-mesenchymal transition through the STAT3 signaling pathway. PMID: 29574157
  5. TNF-alpha plays an important role for the autocrine stimulation of IL-23 production by 6-sulfo LacNAc(+) dendritic cells. PMID: 27315572
  6. The expression of IL-17 and IL-12 in patients with lupus miliaris disseminatus faciei is reported in patients and healthy controls. PMID: 27515793
  7. SIGIRR is both a negative regulator of TLR4 and a positive regulator of TLR7/8. PMID: 28869081
  8. interleukin 23 (IL-23)/T-helper 17 (TH 17) immune axis has been identified as a major immune pathway in psoriasis disease pathogenesis PMID: 28653490
  9. Serum IL-17 and IL-23 values positively correlated with serum total IgE levels. Serum levels of IL-10 were lower in children with atopy and dyslipidemia than patients with dyslipidemia. PMID: 28692864
  10. IL-23/IL-17 axis and biochemical markers in the pathogenesis of Type 2 Diabetes PMID: 28757426
  11. Higher levels of TGF-beta mRNA were observed in biopsies taken from healthy controls, and the IL-23 mRNA levels were significantly increased in the peri-implantitis group (P < 0.0001). No differences in IL-17 mRNA levels were observed between the two groups (P > 0.05). PMID: 27062688
  12. clinical significance of IL-17 and IL-23 in the pathogenesis of different types of gastric neoplasms in humans, is reported. PMID: 27869179
  13. this study shows neuroprotective effects of G-CSF administration in microglia-mediated reactive T cell activation in vitro in a mouse model PMID: 28646409
  14. NOD2 up-regulates TLR2-mediated IL-23p19 expression via increasing c-Rel activation in Paneth cell-like cells PMID: 27563808
  15. Serum IL-23 and IL-17 levels were elevated in patients with aneurysmal subarachnoid hemorrhage (aSAH) showing upregulation of IL-23/IL-17 inflammatory axis after aSAH. Serum IL-23 and IL-17 showed differential correlations with post hemorrhagic complications and no correlation with clinical outcome. PMID: 28609751
  16. IL-23, alone and in combination with IL-18 and sRAGE, identified bacterial meningitis with excellent accuracy. Following validation, these markers could aid clinicians in diagnosis of bacterial meningitis and decision-making regarding prolongation of antibiotic therapy PMID: 29394248
  17. Serum IL-17F predicted increased knee bone marrow lesion scores in females only among patients with knee osteoarthritis. PMID: 27836676
  18. Our discoveries demonstrate that autocrine IL-23 contribute to ovarian cancer malignancy through promoting the self-renewal of CD133+ ovarian cancer stem-like cells, and this suggests that IL-23 and its signaling pathway might serve as therapeutic targets for the treatment of ovarian cancer. PMID: 27738346
  19. Study of IL-23 showed reduced levels of expression in aged humans compared to young. PMID: 28509479
  20. IL-23 activates gammadelta T cells in early stage PNS, which amplifies the Th17 cell population and leads to kidney injury through the secretion of IL-21. PMID: 29119640
  21. serum IL-23 levels reflect obstructive sleep apnea syndrome -related systemic inflammation and are a useful marker for improvement following continuous positive airway pressure therapy PMID: 27665460
  22. This study is the first to demonstrate an effect of HIV on the IL-23 signaling pathway in Th17 cells. We show that in vitro and in vivo HIV infection results in impaired IL-23 signaling which is not reversed by HAART nor is it a result of reduced receptor expression, suggesting that HIV interferes with IL-23-activated signaling pathways PMID: 29091911
  23. We conclude that variants in IL-23A and IL-23R genes were associated with the risk of multiple sclerosis or other inflammatory demyelinating diseases. PMID: 27893410
  24. results confirm the role of IFN-gamma and support the involvement of IL-23/Th17-related cytokines in BCC pathogenesis and in the inflammatory response during IMQ and MAL-PDT treatments PMID: 28829805
  25. An increase in CSF mean levels of IL-23 was observed in amyotrophic lateral sclerosis patients. PMID: 27245439
  26. results show that IL-23 accounts for the main aspects of human and murine lupus including the expansion of double negative T cells, decreased IL-2, and increased IL-17 production PMID: 28646040
  27. Serum Levels of IL-17A and IL-23 Are Associated with Decreased Vitamin D3 and Increased Pain in Osteoarthritis PMID: 27820818
  28. this study shows that latent cytomegalovirus induces IL-23. IL-23 might be an inflammatory mediator of latent cytomegalovirus infection in patients with rnd-stage renal diseases, and predisposes patients for post-transplant cytomegalovirus reactivation PMID: 27716059
  29. These finding may provide a molecular mechanism involved in sustained ER stress in AS BdCs stimulates the activation of RUNX2 and C/EBPbeta genes, leading to IL-23 production. PMID: 28728847
  30. The link between increased expression of TH17 pathway cytokines and clinical disease severity raises the possibility of a new therapeutic paradigm of targeted IL-17/IL-23 intervention for patients with ichthyosis PMID: 27554821
  31. this study shows that elevated iserum IL-23 is associated with mortality in chronic hepatitis B virus, acute-on-chronic liver failure patients, and that IL-23 neutralizing antibodies attenuated liver injury by reducing the expression of Th17-related inflammatory cytokines, neutrophil chemoattractants and stabilization factors within the liver tissue PMID: 28282579
  32. this study shows that IL-23 promotes IL-17+IFN-gamma- T cell expansion in multi-drug-resistant tuberculosis PMID: 27681197
  33. our results suggest that IL-39 induces differentiation and/or expansion of neutrophils in lupus-prone mice. PMID: 27400195
  34. The results of this case-control study suggest that IL-12A, IL-12B, IL12RB1, IL12RB2 and IL23R make no genetic contribution to the susceptibility of Takayasu arteritis in Chinese populations PMID: 26987707
  35. High IL-23 expression is associated with polycystic ovary syndrome. PMID: 27146815
  36. this study shows that for pre-school children with history and physical exam in favor of asthma which cannot be tested by spirometry, IL-23 serum levels may be an auxiliary biomarker for the diagnosis of asthma PMID: 28341820
  37. Data show that the number of interleukin 17 (IL-17) positive cells significantly correlated positively with the number of interleukin-23 (IL-23) positive cells in skin PMID: 27388654
  38. Interleukin 17A (Il17a) and interleukin-23 (IL-23) - dependent interleukin-17 Receptor C (IL-17RC) are expressed by sputum and neutrophils in deltaF508-CFTR protein (F508del) cystic fibrosis patients. PMID: 27155366
  39. suberoylanilide hydroxamic acid significantly inhibited IL-12p40 and IL-23p19 mRNA synthesis and did not change IL-12p35 mRNA transcription. PMID: 27240992
  40. this study shows that single nucleotide polymorphisms of the IL23R-IL12RB2 region are associated with Behcet's disease in a Northern Chinese Han population PMID: 27660093
  41. this study shows that double-negative T cells from systemic lupus erythematosus patients are more expanded when stimulated in vitro with recombinant IL-23 than controls PMID: 27343994
  42. Increased expression of interleukin-23 associated with progression of colorectal cancer. PMID: 27807862
  43. The levels of IL-17, one of the major effector cytokines of the Th17 system, and IL-23, which had been implicated in the generation, survival and expansion of Th17 cells, are altered in Hashimoto's thyroiditis (HT). PMID: 26928603
  44. Intracellular p19 associated with the cytokine receptor subunit gp130 and stimulated the gp130-dependent activation of signal transducer and activator of transcription 3 (STAT3) signaling PMID: 26980441
  45. may role in the pathogenesis of arthritis and may be a useful biomarker for the diagnosis of this disease PMID: 26709220
  46. we showed that elevated IL-17/IL-23 serum concentrations helped to discriminate BP patients who later relapsed. PMID: 26656739
  47. The expression of IL-23 significantly increased in chronic atrophic gastritis with intestinal metaplasia tissues and gastric cancer tissues. PMID: 27053620
  48. that consumption of star fruit juice at 100g twice daily for one month can significantly depress the pro-inflammation cytokines: TNF-alpha, IL-23, and NO, while increasing walking distance. PMID: 26952371
  49. IL-23 mediates the differentiation of Th17 and Treg cells and the production of associated cytokines in DICs. The potential mechanism likely involves the STAT3 pathway. PMID: 26657845
  50. Clostridium difficile toxins A and B induce IL-23 mRNA expression in human dendritic cells. PMID: 25626905
  51. High serum IL-23 levels are associated with rheumatoid arthritis. PMID: 25799392
  52. balance of IL-23 vs IL-12/IL-27 signals into CD4(+) effector T cells determines whether tissue inflammation is perpetuated or resolves PMID: 24796719
  53. Data suggest that up-regulation of IL17 (interleukin 17), IL23 (interleukin 23), and p73 (tumor protein p73) expression in cutaneous melanoma may be biomarker of melanoma invasiveness. PMID: 25793426
  54. The IL-23/Th17 pathway may be involved in the pathogenesis of primary immune thrombocytopenia through enhancement of the Th17 response. PMID: 25621490
  55. potential biomarker for poor therapeutic response in lupus nephritis patients PMID: 25887118
  56. IL23 levels are raised in schizophrenia patients prescribed with depot medication, supporting the role of aberrant cytokine signalling in schizophrenia. PMID: 25769808
  57. this is the first study to report the possible role played by IL-23 and its gene polymorphism in neuro-Behcet's and not only uveitis with a significant relation to disease activity making both potential markers PMID: 25553835
  58. IL-23 plays a pivotal role in the development of oesophageal carcinoma via epithelial-mesenchymal transition. PMID: 25721268
  59. High serum interleukin-23 levels are associated with systemic lupus erythematosus. PMID: 24990863
  60. There is an association with genetic variants in the IL-23 and NF-kappaB pathways that discriminates between mild and severe psoriasis. PMID: 25789703
  61. IL-23 could promote migration of human ESCC cells by activating DLL4/Notch1 signaling pathway PMID: 26062426
  62. IL-17A, IL-17F and IL23R polymorphisms have no effect on expression of IL-6, IL-17, IL-21 and TGF-beta1 mRNAs expression in H. pylori-infected gastritis. PMID: 26151690
  63. 1,25D increased the synergistic effect provided by NOD2 and TLR co-activation on interleukin (IL)-10, IL-23, and tumor necrosis factor-alpha (TNF-alpha). PMID: 24781050
  64. central role in psoriasis pathogenesis PMID: 25769911
  65. Interleukin-23 can be observed and may be associated with inflammatory response and bone resorption in periapical lesions PMID: 23520984
  66. this study is the first to find a clear correlation between high IL-17/IL-23 axis levels and phenotypes of AEDS in children. PMID: 25562560
  67. IL-23 has a role in regulating IL-17A and/or IL-17F positive Th17 cells in chronic periodontitis PMID: 25525302
  68. Plasma level of IL-23 in relapsing remitting multiple sclerosis patients was significantly increased compared to control subjects. PMID: 25083738
  69. Data iindicate that interleukin-23 (IL-23) is critical for the development of proteoglycan-induced arthritis (PGIA) after subcutaneous but not intraperitoneal induction. PMID: 25253467
  70. mTORC2 regulates lipopolysaccharides-induced expression of IL-12 and IL-23 in human dendritic cells. PMID: 25877925
  71. IL-23 level increased significantly in the serum and urine of SLE patients with and without lupus nephritis compared to controls. Urine levels of IL-23 were correlated with the renal SLE Disease Activity Index score and 24-h urinary protein levels. PMID: 25562331
  72. Knocking down the expression of MMP2 in melanoma cells resulted in inhibition of IL-23-induced invasiveness PMID: 25639230
  73. High gene copy numbers of IL17F and IL23A were associated with Behcet's disease and Vogt-Koyanagi-Harada syndrome. PMID: 25439430
  74. IL-23 has a role in disease progression in patients with carotid atherosclerosis, potentially involving IL-17-related mechanisms PMID: 25649806
  75. Data indicate that IL-23 p19, IL-23 p40 (IL-12 p40) and IL-23 receptor (IL-23R) were cytoplasmic/membranous over-expressed in colorectal cancer and normal tissues, but were reduced in lymph node metastases. PMID: 25015728
  76. selective IL-4-mediated IL-23/T(H)17 silencing is promising as treatment against harmful inflammation, while sparing the IL-12-dependent T(H)1 responses PMID: 25646481
  77. IL-23 may play an important role in the development of Graves' disease, and the IL-23A gene is a genetic risk marker for Graves' disease in Han Chinese population. PMID: 25670394
  78. genetic variation at IL12B, IL23R and IL23A has an influence not only on the risk for psoriasis but also on disease severity and type 2 diabetes mellitus PMID: 24957500
  79. HIV gp120-induced IL-23 upregulated suppressor of cytokine signaling 1 (SOCS1) protein in T cells, which inhibited IFN-gamma production. PMID: 25234720
  80. The IL-23/IL-23R/IL-12Rbeta1 complex formation does not follow the classical "site I-II-III" architectural paradigm. PMID: 25371211
  81. IL-23 levels correlate well with disease activity and functional disability but not with radiographic joint damage in rheumatoid arthritis. PMID: 24924839
  82. Serum IL-17 and IL-23 levels demonstrate no association with type 1 and type 2 diabetes, but, in line with previous studies, TGF-beta levels were lower in type 1 diabetic patients PMID: 24995325
  83. the IL-23/IL-17 axis may play a crucial role in the immunopathogenesis pemphigus vulgaris PMID: 24899786
  84. preoperative serum IL23 has no outcome prognostic value in patients with colorectal cancer PMID: 24909386
  85. IL-23 plays a role in enteropathic arthritis patients with inflammatory bowel disease PMID: 24384828
  86. zymosan-induced il23a mRNA expression is best explained through coordinated kappaB- and ATF2-dependent transcription; and (iii) il23a expression relies on complementary phosphorylation of ATF2 on Thr-69 and Thr-71 dependent on PKC and MAPK activities. PMID: 24982422
  87. A review of both experimental and human data that supports the hypothesis of a key pathogenic role of IL-23/Th17 axis in psoriasis. PMID: 24568095
  88. TSLP synergized with CD40 ligand to promote dendritic cell activation and pathogenic IL-23 production by primary blood and skin dendritic cells. PMID: 24910175
  89. Autophagy appears to be associated with intestinal modulation of IL-23 in ankylosing spondylitis. PMID: 23740229
  90. In conclusion, here we show that STAT3 activation can be one of the molecular mechanisms leading to KSHV-mediated DC dysfunction, that might allow viral persistence and the onset of KSHV-associated malignancies. PMID: 24577500
  91. role in pemphigus vulgaris PMID: 23268293
  92. the IL-23/Th17 axis is involved in the immune response to anthrax in humans. PMID: 24643777
  93. IL-23 does not induce IL-7 expression in microglia and astrocytes. PMID: 24224652
  94. The serum levels of IL-23 and IL-17 in Primary biliary cirrhosis patients were positively correlated with serum gamma-glutamyltransferase levels. PMID: 23910013
  95. These data suggest a role for IL23 in the psoriatic arthritis pathogenesis in Romanians. PMID: 23673284
  96. Data show that IFN-gamma induced the production of IL-12/23p40 and IL-23p19 mRNA as well as IL-12p40 and IL-23 proteins positively regulated by the p38 mitogen-activated protein kinases (MAPKs) in monocytes isolated through anti-CD14 microbeads. PMID: 23679818
  97. this study indicates that the IL-23/IL-17A axis plays a pivotal role in inflammatory bowel diseases pathogenesis through the NO pathway. PMID: 23472658
  98. Levels of IL-23 produced by CD16+ monocytes from HIV-1-infected subjects in response to E. coli stimulation were higher than those produced by PBMC from uninfected subjects. PMID: 24067979
  99. findings show the GG haplotype of lL23A variants (rs11171806 and rs2066808) was protective against Type 1 diabetes PMID: 23579029
  100. These data provide novel insights into a yet unrecognized mechanism of HBV-induced hepatitis, by which increases in IL-23 expression, through an MR/endocytosis-dependent or -independent manner, produce liver damage through the IL-23/IL-17 axis. PMID: 23825942

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Subcellular Location Secreted
Protein Families IL-6 superfamily
Tissue Specificity Secreted by activated dendritic and phagocytic cells and keratinocytes. Also expressed by dermal Langerhans cells (at protein level).
Database Links

HGNC: 15488

OMIM: 605580

KEGG: hsa:51561

STRING: 9606.ENSP00000228534

UniGene: Hs.382212

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