Recombinant Mouse Interleukin-36 gamma protein(Il36g) (Active)

In Stock
Code CSB-AP003131MO
Product Type Interleukin
Size US$112Purchase it in Cusabio online store
(only available for customers from the US)
Uniprot No. Q8R460
Lead Time 5-10 business days
Storage Buffer 0.2 m filtered 20 mM Tris-HCl, pH 8.5, 150mM NaCl with Tween-20 ,lyophilized
Alias Interleukin-1 family member 9
Species Mus musculus (Mouse)
Biological_Activity Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion in murine NIH/3T3 cells is less than 10 ng/ml, corresponding to a specific activity of >1.0x105 IU/mg.
Purity >98% as determined by SDS-PAGE and HPLC.
Endotoxin Less than 1.0 EU/μg as determined by LAL method.
Research Area Immunology
Source E.coli
Gene Names Il36g
Expression Region 13-164aa
Tag Info Tag-Free
Mol. Weight 17.3 kDa
Protein Description Full Length of Mature Protein
PubMed ID 11991723; 15489334; 21860022; 21965679
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Function Functions as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. May play a role in proinflammatory responses during particular neutrophilic airway inflammation. May be involved in the innate immune response to fungal pathogens. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes.
Subcellular Location Secreted
Protein Families IL-1 family
Database Links

UniGene: Mm.249379

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