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| Code | CSB-AP003131MO |
| Product Type | Interleukin |
| Size |
US$112Purchase it in Cusabio online store (only available for customers from the US) |
| Uniprot No. | Q8R460 |
| Lead Time | 5-10 business days |
| Storage Buffer | 0.2 m filtered 20 mM Tris-HCl, pH 8.5, 150mM NaCl with Tween-20 ,lyophilized |
| Alias | Interleukin-1 family member 9 |
| Species | Mus musculus (Mouse) |
| Biological_Activity | Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion in murine NIH/3T3 cells is less than 10 ng/ml, corresponding to a specific activity of >1.0x105 IU/mg. |
| Purity | >98% as determined by SDS-PAGE and HPLC. |
| Endotoxin | Less than 1.0 EU/μg as determined by LAL method. |
| Sequence | GRETPDFGEV FDLDQQVWIF RNQALVTVPR SHRVTPVSVT ILPCKYPESL EQDKGIAIYL GIQNPDKCLF CKEVNGHPTL LLKEEKILDL YHHPEPMKPF LFYHTRTGGT STFESVAFPG HYIASSKTGN PIFLTSKKGE YYNINFNLDI KS |
| Research Area | Immunology |
| Source | E.coli |
| Gene Names | Il36g |
| Expression Region | 13-164aa |
| Tag Info | Tag-Free |
| Mol. Weight | 17.3 kDa |
| Protein Description | Full Length of Mature Protein |
| PubMed ID | 11991723; 15489334; 21860022; 21965679 |
| Still Have Questions? | Leave a Message or Start an on-line Chat |
| Function | Functions as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP (By similarity). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. May play a role in proinflammatory responses during particular neutrophilic airway inflammation. May be involved in the innate immune response to fungal pathogens. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4(+) T-cells and splenocytes. |
| Subcellular Location | Secreted |
| Protein Families | IL-1 family |
| Database Links |
UniGene: Mm.249379 |
Il36g Proteins for Mus musculus (Mouse)
| Code | Product Name | Source |
|---|---|---|
| CSB-YP840290MO CSB-EP840290MO CSB-BP840290MO CSB-MP840290MO |
Recombinant Mouse Interleukin-36 gamma(Il36g) | Yeast E.coli Baculovirus Mammalian cell |
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