TIMP1 Monoclonal Antibody

Datasheet
Code CSB-MA0235601A0m
Product Type Monoclonal Antibody
Size US$350Purchase it in Cusabio online store
(Shop online in the US. Customers outside the US,
please order from local distributors.)
Uniprot No. P01033
Image
  • All lanes:Mouse anti-Human Timp1 monoclonal antibody at 1μg/ml
    Lane 1: HepG-2 cell lysate
    Predicted band size : 23 kDa
    Observed band size : 23 kDa
    Additional bands at:50KD

  • All lanes: Mouse anti-Human Timp1 monoclonal antibody at 1μg/ml
    Lane 1: TIMP1 transfected pichia Yeast cell lysate
    Predicted band size : 23 kDa
    Observed band size:23 kDa

  • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-MA0235601A0m at dilution of 1:100

Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Human Timp 1
Raised in mouse
Species Reactivity Human,Mouse
Specificity specific for Human Timp1 denatured and native forms
Tested Applications ELISA,WB,IHC;Recommended dilution:WB:1:500-1:5000,IHC:1:50-1:500
Relevance Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Form liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 15mmol/L NaN3Constituents: 0.1mol/L Nacl
Purification Method >95%, Protein G purified
Isotype IgG2a
Clonality monoclonal
Alias timp-1
Immunogen Species Homo sapiens (Human)
Gene Names TIMP1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Clone No. 8B4E9
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Function Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
Subcellular Location Secreted
Protein Families Protease inhibitor I35 (TIMP) family
Tissue Specificity Detected in rheumatoid synovial fluid (at protein level).
Database Links

HGNC: 11820

OMIM: 305370

KEGG: hsa:7076

STRING: 9606.ENSP00000218388

UniGene: Hs.522632

Pathway HIF-1 signaling pathway

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