Product Details

Purity

Greater than 90% as determined by SDS-PAGE.
Greater than 90% as determined by SEC-HPLC.

Endotoxin

Less than 1.0 EU/ug as determined by LAL method.

Activity

Measured by its binding ability in a functional ELISA. Immobilized Human CD93 at 2 μg/mL can bind Human IGFBP7 (CSB-MP620956HUd9), the EC₅₀ is 20.34-26.92 ng/mL.Measured by its binding ability in a functional ELISA. Immobilized Human CD93 at 2 μg/mL can bind Anti-CD93 recombinant antibody (CSB-RA865099MA1HU), the EC₅₀ is 0.6639-1.173 ng/mL.

Target Names

CD93

Uniprot No.

Q9NPY3

Alternative Names

(C1q/MBL/SPA receptor)(CDw93)(Complement component 1 q subcomponent receptor 1)(Matrix-remodeling-associated protein 4)(CD_antigen: CD93)(C1qR)(C1qR(p))(C1qRp)

Molecular Characterization

Species

Homo sapiens (Human)

Source

Mammalian cell

Expression Region

22-580aa

Target Protein Sequence

TGADTEAVVCVGTACYTAHSGKLSAAEAQNHCNQNGGNLATVKSKEEAQHVQRVLAQLLRREAALTARMSKFWIGLQREKGKCLDPSLPLKGFSWVGGGEDTPYSNWHKELRNSCISKRCVSLLLDLSQPLLPSRLPKWSEGPCGSPGSPGSNIEGFVCKFSFKGMCRPLALGGPGQVTYTTPFQTTSSSLEAVPFASAANVACGEGDKDETQSHYFLCKEKAPDVFDWGSSGPLCVSPKYGCNFNNGGCHQDCFEGGDGSFLCGCRPGFRLLDDLVTCASRNPCSSSPCRGGATCVLGPHGKNYTCRCPQGYQLDSSQLDCVDVDECQDSPCAQECVNTPGGFRCECWVGYEPGGPGEGACQDVDECALGRSPCAQGCTNTDGSFHCSCEEGYVLAGEDGTQCQDVDECVGPGGPLCDSLCFNTQGSFHCGCLPGWVLAPNGVSCTMGPVSLGPPSGPPDEEDKGEKEGSTVPRAATASPTRGPEGTPKATPTTSRPSLSSDAPITSAPLKMLAPSGSPGVWREPSIHHATAASGPQEPAGGDSSVATQNNDGTDGQK

Mol. Weight

60.1 kDa

Protein Length

Partial

Tag Info

C-terminal 10xHis-tagged

Form

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.

Buffer

Lyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Troubleshooting and FAQs

Protein FAQs

Storage Condition

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shelf Life

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Lead Time

Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Notes

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Datasheet & COA

Please contact us to get it.

Description

CD93, also called complement component 1, q subcomponent receptor (C1qRp), is a protein found on the surface of different cell types like endothelial cells, white blood cells, and stem cells [1][2]. It's involved in lots of important jobs in the body, including helping blood vessels grow, controlling inflammation, and cleaning up dead cells [3][4][5][6][7][8][9][10][11][2]. In cancer, CD93 seems to help blood vessels form in tumors by organizing cells and structures within them [3]. It's also important in diseases like age-related macular degeneration, where it affects inflammation and blood vessel growth in the eye [8][7]. CD93 even helps clear away dead cells by shedding a part of itself, acting as a signal for other cells to come and clean up [5][12]. Plus, it's involved in the process of cells engulfing and digesting other cells, and it interacts with certain proteins to help regulate this process [11]. In development, CD93 seems to have a say in how certain cells grow and stick together [6][10]. Overall, CD93 is a potential target for treatments that aim to stop blood vessel growth in diseases like pancreatic cancer [13].

References:
[1] S. Bohlson, R. Silva, M. Fonseca, & A. Tenner, "Cd93 is rapidly shed from the surface of human myeloid cells and the soluble form is detected in human plasma", The Journal of Immunology, vol. 175, no. 2, p. 1239-1247, 2005. https://doi.org/10.4049/jimmunol.175.2.1239
[2] N. Ikewaki, J. Kulski, & H. Inoko, "Regulation of cd93 cell surface expression by protein kinase c isoenzymes", Microbiology and Immunology, vol. 50, no. 2, p. 93-103, 2006. https://doi.org/10.1111/j.1348-0421.2006.tb03774.x
[3] R. Lugano, K. Vemuri, D. Yu, M. Bergqvist, A. Smits, M. Essandet al., "Cd93 promotes β1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis", Journal of Clinical Investigation, vol. 128, no. 8, p. 3280-3297, 2018. https://doi.org/10.1172/jci97459
[4] E. Langenkamp, L. Zhang, R. Lugano, H. Huang, T. Elhassan, M. Georganakiet al., "Elevated expression of the c-type lectin cd93 in the glioblastoma vasculature regulates cytoskeletal rearrangements that enhance vessel function and reduce host survival", Cancer Research, vol. 75, no. 21, p. 4504-4516, 2015. https://doi.org/10.1158/0008-5472.can-14-3636
[5] J. Blackburn, D. Lau, E. Liu, J. Ellins, A. Vrieze, E. Pawlaket al., "Soluble cd93 is an apoptotic cell opsonin recognized by αxβ2", European Journal of Immunology, vol. 49, no. 4, p. 600-610, 2019. https://doi.org/10.1002/eji.201847801
[6] Q. Liang, L. Su, D. Zhang, & J. Jiao, "Cd93 negatively regulates astrogenesis in response to mmrn2 through the transcriptional repressor zfp503 in the developing brain", Proceedings of the National Academy of Sciences, vol. 117, no. 17, p. 9413-9422, 2020. https://doi.org/10.1073/pnas.1922713117
[7] S. Trivigno, "The c-type lectin receptor cd93 regulates platelet activation and surface expression of the protease activated receptor 4", Thrombosis and Haemostasis, vol. 124, no. 02, p. 122-134, 2023. https://doi.org/10.1055/a-2166-5841
[8] G. Tosi, E. Caldi, B. Parolini, P. Toti, G. Neri, F. Nardiet al., "Cd93 as a potential target in neovascular age‐related macular degeneration", Journal of Cellular Physiology, vol. 232, no. 7, p. 1767-1773, 2016. https://doi.org/10.1002/jcp.25689
[9] B. Wu, L. Fu, X. Guo, H. Hu, L. Yang, Y. Shiet al., "Multi-omics profiling and digital image analysis reveal the potential prognostic and immunotherapeutic properties of cd93 in stomach adenocarcinoma", Frontiers in Immunology, vol. 14, 2023. https://doi.org/10.3389/fimmu.2023.984816
[10] M. Zhang, S. Bohlson, M. Dy, & A. Tenner, "Modulated interaction of the erm protein, moesin, with cd93", Immunology, vol. 115, no. 1, p. 63-73, 2005. https://doi.org/10.1111/j.1365-2567.2005.02120.x
[11] S. Bohlson, M. Zhang, C. Ortiz, & A. Tenner, "Cd93 interacts with the pdz domain-containing adaptor protein gipc: implications in the modulation of phagocytosis", Journal of Leukocyte Biology, vol. 77, no. 1, p. 80-89, 2004. https://doi.org/10.1189/jlb.0504305
[12] B. Jw, L. Dh, J. Ellins, A. Kipp, P. En, D. Jdet al., "Soluble cd93 is an apoptotic cell opsonin recognized by the αxβ2integrin",, 2018. https://doi.org/10.1101/341933
[13] H. Zhang, Z. Dai, Y. Liao, C. Yan, B. Zhao, T. Liuet al., "Cd248(tem1/cd164l1/endosialin): a new molecular target for anti-angiogenic therapy in pancreatic ductal adenocarcinoma",, 2021. https://doi.org/10.21203/rs.3.rs-217476/v1

Target Background

Function

Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.

Gene References into Functions

Report increased CD93 expression in patients with chronic plaque psoriasis and propose the C allele of rs2749817 as a new risk allele for psoriasis. PMID: 28421233
Results show that CD93 and MMRN2 are co-expressed in the blood vessels of various tumors and their interaction modulates the angiogenic process. PMID: 28912033
These findings identify novel protein interactions involving CLEC14A, CD93 and CD248 with MMRN2 as targetable components of vessel formation PMID: 28671670
CD93 and Other Plasma Cell Survival Factor Genes Associated with Measles-Specific Antibody Response after Vaccination PMID: 27529750
Soluble expression of disulfide-bonded C-type lectin like domain of human CD93 in the cytoplasm of Escherichia coli. The recombinant protein could alter LPS pro-inflammatory activity on THP1 cells. PMID: 27742562
Vascular CD93 expression is elevated in nasopharyngeal carcinoma and is correlated with T classification, N classification, distant metastasis, clinical stage and poor prognosis (all P < 0.05). In addition, overexpression of CD93 promoted angiogenesis in vitro. PMID: 27255994
both transmembrane and soluble CD93 are overexpressed in patients with neovascular Age-Related Macular Degeneration. PMID: 27859225
Elevated serum sCD93 levels reflected exacerbated status of allergic diseases, including CSU [chronic spontaneous urticaria ], AR[allergic rhinitis], and asthma. ICS [inhaled corticosteroid] use significantly diminished serum sCD93 levels in steroid-naive patients with BA[Bronchial asthma]. This result may suggest sCD93 in serum as a therapeutic marker for allergic inflammation. PMID: 28332366
Data show that CD93 antigen proved to be phosphorylated on tyrosine 628 and 644 following cell adhesion on laminin through dystroglycan. PMID: 26848865
CD93 expression identifies a predominantly cycling, non-quiescent leukemia-initiating cell population in MLL-rearranged AML, providing opportunities for selective targeting and eradication of LSCs. PMID: 26387756
The T/T genotype of SNP rs2749817 of CD93 is associated with disseminated cancer. PMID: 26008729
CD93 is a key regulator of glioma angiogenesis and vascular function, acting via cytoskeletal rearrangements required for cell-cell and cell-matrix adhesion. PMID: 26363010
These data support a mechanism whereby gC1qR plays an important role in HPV-16 E2-induced human cervical squamous carcinoma cell apoptosis via a mitochondria-dependent pathway. PMID: 25288439
The data indicate that gC1qR inhibits viability, migration and proliferation of cervical squamous cells carcinoma via the p38 MAPK signalling pathway. PMID: 23052251
Antibody-dependent enhancement of parvovirus B19 involves an alternative mechanism mediated by the heat-sensitive complement factor C1q and its receptor, CD93. PMID: 24807719
Expression of CD93 on the lymphocyte population of peripheral blood cells from infants at 1 month after birth was also significantly decreased, compared with that for neonatal umbilical cord blood. PMID: 24033555
HPV 16 E2 induces apoptosis by silencing the gC1qR gene or inhibiting p38 MAPK/JNK signalling in cervical squamous cell carcinoma PMID: 23651874
These data support a mechanism whereby gC1qR induces apoptosis through the mitochondrial and p53-dependent pathways in cervical squamous cell carcinoma. PMID: 23268996
soluble EGF-like domain containing CD93 protein is a novel angiogenic factor acting on the endothelium PMID: 23272129
[review] Following a comprehensive summary of CD93 expression patterns, this review focuses on recent findings that address the putative function of CD93 in inflammation and innate immunity. PMID: 22206251
Data show that Pic, a class 2 SPATE protein produced by Shigella flexneri 2a targets a broad range of human leukocyte glycoproteins including CD43, CD44, CD45, CD93, CD162 and the surface-attached chemokine fractalkine. PMID: 21768350
Results suggest that the plasma concentration of soluble CD93 is a potential novel biomarker for Coronary Artery Disease (CAD), including MI. PMID: 21332844
expression on naive T lymphocytes (CD4(+)CD45RA (+) cells) in human neonatal umbilical cord blood PMID: 20512406
both B1 receptor and gC1q receptor are involved in the vascular leakage induced by hereditary and acquired angioedema plasma. PMID: 19796797
To clarify the cellular and molecular properties of C1qRp it has been demonstrated that C1q does not show enhanced binding to C1qRp-transfected cells, is not a receptor for C1q, and is identical to CD93 with functions relevant to intercellular adhesion. PMID: 11994479
C1qRp defines a new human stem cell population with hematopoietic and hepatic potential PMID: 12140365
O-glycosylation is important in the stable cell surface expression of C1qRP/CD93 PMID: 12891708
Taken together, these findings indicate that the expression of the CD93 molecule identified by CD93 mAb (mNI-11) is dramatically decreased on U937 cells with apoptotic properties PMID: 18094537
RNAi-mediated suppression of gC1qR/p32 markedly reduced HTNV binding and infection in human lung epithelial A549 cells PMID: 18834607

Hide All

Subcellular Location

Membrane; Single-pass type I membrane protein.

Tissue Specificity

Highly expressed in endothelial cells, platelets, cells of myeloid origin, such as monocytes and neutrophils. Not expressed in cells of lymphoid origin.

Database Links

HGNC: 15855

OMIM: 120577

KEGG: hsa:22918

STRING: 9606.ENSP00000246006

UniGene: Hs.97199

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Code	CSB-MP865099HU
MSDS	MSDS Datasheet
Size	$114
	Order now
Image	(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel. Activity Measured by its binding ability in a functional ELISA. Immobilized Human CD93 at 2 μg/ml can bind Anti-CD93 recombinant antibody (CSB-RA865099MA1HU), the EC₅₀ is 0.6639-1.173 ng/mL. Biological Activity Assay Activity Measured by its binding ability in a functional ELISA. Immobilized Human CD93 at 2 μg/ml can bind Human IGFBP7 (CSB-MP620956HUd9), the EC₅₀ is 20.34-26.92 ng/mL. Biological Activity Assay The purity of CD93 was greater than 90% as determined by SEC-HPLC
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Recombinant Human Complement component C1q receptor (CD93), partial (Active)

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