CD47|Proteinase K|EGFR|BCMA|PD-L1|CD276|ACE2|TMPRSS2|Exosome Isolation Kits
Code | CSB-PA008357 |
Size | US$167 |
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Have Questions? | Leave a Message or Start an on-line Chat |
Uniprot No. | Q9NZN5 | ||||||
Target Names | ARHGEF12 | ||||||
Alternative Names | ARHGC_HUMAN antibody; ARHGEF12 antibody; KIAA0382 antibody; leukemia-associated rho guanine nucleotide exchange factor antibody; Leukemia-associated RhoGEF antibody; PRO2792 antibody; Rho guanine exchange factor (GEF) 12 antibody; Rho guanine nucleotide exchange factor (GEF) 12 antibody; Rho guanine nucleotide exchange factor 12 antibody; Similar to Mouse Lsc oncogene antibody | ||||||
Raised in | Rabbit | ||||||
Species Reactivity | Human,Mouse,Rat | ||||||
Immunogen | Synthesized peptide derived from the Internal region of Human LARG. | ||||||
Immunogen Species | Homo sapiens (Human) | ||||||
Conjugate | Non-conjugated | ||||||
Isotype | IgG | ||||||
Purification Method | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | ||||||
Concentration | It differs from different batches. Please contact us to confirm it. | ||||||
Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. | ||||||
Form | Liquid | ||||||
Tested Applications | WB, ELISA | ||||||
Recommended Dilution |
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Protocols | Western Blotting(WB) Protocol ELISA Protocol |
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Troubleshooting and FAQs | Antibody FAQs | ||||||
Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||
Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
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Function | May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. |
Gene References into Functions |
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Involvement in disease | A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with KMT2A/MLL1. |
Subcellular Location | Cytoplasm, Membrane |
Tissue Specificity | Ubiquitously expressed. Isoform 2 is found in jejunum and testis. |
Database Links |
HGNC: 14193 OMIM: 604763 KEGG: hsa:23365 STRING: 9606.ENSP00000380942 UniGene: Hs.24598 |