Code | CSB-PA006389LA01HU |
Size | US$299 |
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Full Product Name | Rabbit anti-Homo sapiens (Human) CYP11A1 Polyclonal antibody | ||||||
Uniprot No. | P05108 | ||||||
Target Names | CYP11A1 | ||||||
Alternative Names | Cholesterol 20 22 desmolase antibody; Cholesterol desmolase antibody; Cholesterol monooxygenase (side chain cleaving) antibody; Cholesterol side chain cleavage enzyme antibody; Cholesterol side chain cleavage enzyme mitochondrial antibody; Cholesterol side-chain cleavage enzyme antibody; CP11A_HUMAN antibody; CYP11A antibody; CYP11A1 antibody; CYPXIA1 antibody; Cytochrome P450 11A1 antibody; Cytochrome P450 11A1 mitochondrial antibody; Cytochrome P450 family 11 subfamily A polypeptide 1 antibody; Cytochrome P450 subfamily XIA antibody; Cytochrome P450(scc) antibody; Cytochrome P450C11A1 antibody; mitochondrial antibody; P450SCC antibody; Steroid 20 22 lyase antibody | ||||||
Raised in | Rabbit | ||||||
Species Reactivity | Human, Rat | ||||||
Immunogen | Recombinant Human Cholesterol side-chain cleavage enzyme, mitochondrial protein (40-521AA) | ||||||
Immunogen Species | Homo sapiens (Human) | ||||||
Conjugate | Non-conjugated The CYP11A1 Antibody (Product code: CSB-PA006389LA01HU) is Non-conjugated. For CYP11A1 Antibody with conjugates, please check the following table. |
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Clonality | Polyclonal | ||||||
Isotype | IgG | ||||||
Purification Method | >95%, Protein G purified | ||||||
Concentration | It differs from different batches. Please contact us to confirm it. | ||||||
Buffer | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
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Form | Liquid | ||||||
Tested Applications | ELISA, WB, IHC | ||||||
Recommended Dilution |
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Protocols | ELISA Protocol Western Blotting(WB) Protocol Immunohistochemistry (IHC) Protocol |
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Troubleshooting and FAQs | Antibody FAQs | ||||||
Storage | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | ||||||
Lead Time | Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time. |
Applications : WB
Sample type: Mouse MLTC‐1 cells
Review: Western blotting results of Cyp11a1 and StAR, protein expression in MLTC‐1. (f,g) The quantification analysis of Cyp11a1 and StAR protein expression.
By Anonymous
Applications : IF/IHC
Sample type: Chicken Granulosa cells
Review: The POFs were cultured for 72 hr. H&E staining was used to evaluate the morphology of POFs after 72 hr in culture. STAR and CYP11A1 immunohistochemistry staining and BrdU incorporation were performed to characterize the POFs’ culture system. Scale bar: 50 μm. The POFs were incubated with BrdU. Red fluorescence represents BrdU‐labeled cells. Blue fluorescence represents the DAPI.
By Anonymous
Applications : Fluorescence
Sample type: Cells
Sample dilution: 1:100
Review: Cells (red) were distributed in the GL of D580-SWFs after treatment with BMP4. Red: CYP11a1 and CYP19a1; green: BMPR1A; CYP11a1 and BMPR1A and CYP19a1 and BMPR1 were coexpressed in the GL of D580-SWFs (treated by BMP4 or GCs.
By Anonymous
Applications : western blot analysis
Sample type: cell
Review: Western blot showed the relative protein expression levels of CYP11A1 and STAR in GCs after treatment with miR-10a-5p mimics and inhibitor.
By Anonymous
Applications : WB
Sample type: cells
Review: Western blot analysis showed that the expression of steroid hormone production-related proteins (CYP11A1) was markedly upregulated by treatment with AdipoRon at a concentration of 10 μg/mL.
By Anonymous
Function |
A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
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Gene References into Functions |
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Involvement in disease | Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) |
Subcellular Location | Mitochondrion inner membrane; Peripheral membrane protein. |
Protein Families | Cytochrome P450 family |
Database Links |
HGNC: 2590 OMIM: 118485 KEGG: hsa:1583 STRING: 9606.ENSP00000268053 UniGene: Hs.303980 |