FABP7 Antibody, HRP conjugated

Code CSB-PA007956LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) FABP7 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
B FABP antibody; B-FABP antibody; BFABP antibody; BLBP antibody; Brain lipid binding protein antibody; Brain lipid-binding protein antibody; Brain-type fatty acid-binding protein antibody; DKFZp547J2313 antibody; FABP 7 antibody; FABP7 antibody; FABP7_HUMAN antibody; FABPB antibody; Fatty Acid Binding Protein 7 antibody; Fatty acid binding protein 7 brain antibody; Fatty acid binding protein brain antibody; Fatty acid-binding protein 7 antibody; Fatty acid-binding protein, brain antibody; Mammary derived growth inhibitor related antibody; Mammary-derived growth inhibitor related antibody; MRG antibody; OTTHUMP00000017119 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Fatty acid-binding protein, brain protein (2-132AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers.
Gene References into Functions
  1. Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7. PMID: 28435883
  2. BLBP was highly expressed in glioblastoma tissues.Increased BLBP expression in glioblastoma is associated with poor survival.BLBP mediates the proliferation of human glioblastoma cells by regulating ERK1/2 signaling pathway. PMID: 29288341
  3. Data indicate that the levels of fatty acid binding protein 7 (FABP7) dramatically decreased during passage of the renal cell carcinomas (RCCs) cell line TUHR14TKB. PMID: 28292269
  4. FABP7 is overexpressed in clear cell renal cell carcinoma and promotes cell growth by the activation of ERK and Stat3 signaling pathways PMID: 25192834
  5. FABP7 and HMGCS2 may have roles in apocrine differentiation categorizing apocrine carcinoma of the breast PMID: 25389781
  6. The mRNA/protein expressions of FABP7 was lower in the stenotic colon segment tissue than in the normal colon segment tissue of Hirschsrung disease patients. PMID: 24966941
  7. These results suggest an important role of Rev-erbalpha and Fabp7 in adult neurogenesis. PMID: 24932636
  8. identified 98 transposable element-FABP7 gene chimeric transcripts that were exclusively expressed in primary diffuse large B-cell lymphoma (DLBCL) cases and confirmed several in DLBCL-derived cell lines PMID: 25114248
  9. FABP7 and FABP5 are differentially expressed in oligodendrocyte lineage cells and regulate their proliferation and/or differentiation. PMID: 24114376
  10. Our data introduces FABP7 as a marker for glioma stem cells and further highlights its possible significance for glioma diagnosis and treatment. PMID: 24274717
  11. Report feasibility of detecting B-FABP as biomarker for ischemic brain damage during extrcorporeal circulation in coronary artery bypass grafting patients. PMID: 23020859
  12. FABP7 is almost exclusively expressed in neurospheres and not in the adherent cells, derived from the same glioblastoma tumor. PMID: 23284888
  13. A fatty acid-binding protein 7/RXRbeta pathway enhances survival and proliferation in triple-negative breast cancer. PMID: 22322885
  14. Considerable heterogeneity in expression patterns of FABP7 within breast cancer elates to differences in biological behaviour especially in basal-like breast cancer. PMID: 22562177
  15. identified its binding target by proteomic analysis as fatty acid binding protein 7 (FABP7), also known as brain lipid binding protein) which is highly expressed in neural stem cells and localized in the cytoplasm PMID: 22689954
  16. These data provide the first evidence of direct transactivation of the FABP7 proximal promoter by PAX6 and suggest a synergistic mechanism for PAX6 and other co-factor(s) in regulating FABP7 expression in malignant glioma. PMID: 22583899
  17. Data show that three putative FABP7 promoter regions drive reporter gene expression in renal cell carcinoma cell lines, but not in the HEK293 cell line. PMID: 21771320
  18. expression of BLBP in activated astrocytes negatively correlates with disease duration and in parallel with remyelination failure PMID: 21620951
  19. BFABP is involved in cell proliferation and migration of human renal carcinoma cells. PMID: 21399875
  20. High FABP7 is associated with malignant glioma. PMID: 20834042
  21. We have identified a novel subgroup of basal phenotype (BP) class of breast cancers showing FABP7 expression that have significantly better clinical outcome. PMID: 19590950
  22. this study is the first to demonstrate overexpression of FABP-7 in triple-negative breast cancers PMID: 19608352
  23. FABP7 may function as a tumor progression gene in melanoma PMID: 19587692
  24. overall structure exhibits the typical backbone conformation described for other members of the FABP family, consisting of antiparallel beta-strands that form two almost orthogonal beta-sheets, a helix-turn-helix motif and a short N-terminal helical loop PMID: 12479569
  25. BLBP, stimulated by Ras-independent pathways, regulates Schwann cell-axon interactions in normal peripheral nerve and peripheral nerve tumors. PMID: 12612091
  26. Overexpression of FABP7 in Down syndrome fetal brains. PMID: 12771203
  27. data indicate that MRG is a mediator of the differentiating effects of pregnancy on breast epithelium PMID: 12975368
  28. A possible mechanism for the association of nuclear FABP7 & poor prognosis of glioblastoma multiforme is that nuclear FABP7 may be induced by EGFR activation to promote migration of GBM tumor cells. PMID: 16623952
  29. relation between FABP7, astrocytic features, invasion and poor prognosis and suggests that EGFR amplification is associated with nuclear translocation of FABP7. PMID: 17415524
  30. There were not significant difference in B-FABP expression between ductal infiltrating carcinoma and benign tissue in human breast cancer. PMID: 17428383
  31. Upregulation of FABP7 in renal cell carcinoma was confirmed by quantitative RT-PCR. PMID: 17646957
  32. B-FABP expression in malignant glioma cells is accompanied by the appearance of radial glial-like properties, as well as reduced transformation. B-FABP depletion results in decreased migration, reduction in cell processes, & a more transformed phenotype. PMID: 17898869
  33. Decreased expression of FABP-7 in fetal cystic adenomatoid malformation (CCAM) suggests FABP-7 may have a role in pulmonary development and in the pathogenesis of CCAM. PMID: 18391847
  34. Both in vitro Reelin treatment and overexpression of Notch-1 intracellular domain induced BLBP expression and a radial glial phenotype in an immortalized human neural progenitor cell line, isolated from the cortex of 14 weeks old fetus PMID: 18593473
  35. High expression of FABP7 is associated with melanoma PMID: 18826602
  36. NFI family of transcription factors plays a key role in the regulation of both the B-FABP and GFAP genes in malignant glioma cells. PMID: 19540848
  37. Increases tumor cell motility in vitro and over-expression is associated with poor prognosis in glioblastoma patients PMID: 15827123
  38. Functional analysis in mice. PMID: 12975368

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Subcellular Location
Cytoplasm.
Protein Families
Calycin superfamily, Fatty-acid binding protein (FABP) family
Tissue Specificity
Expressed in brain and other neural tissues.
Database Links

HGNC: 3562

OMIM: 602965

KEGG: hsa:2173

STRING: 9606.ENSP00000357429

UniGene: Hs.26770

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