Recombinant Human Fatty acid-binding protein, brain (FABP7)

Code CSB-YP007956HU
MSDS
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Source Yeast
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Code CSB-EP007956HU
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Source E.coli
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Code CSB-EP007956HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP007956HU
MSDS
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Source Baculovirus
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Code CSB-MP007956HU
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Uniprot No.
Alternative Names
B FABP; B-FABP; BFABP; BLBP; Brain lipid binding protein; Brain lipid-binding protein; Brain-type fatty acid-binding protein; DKFZp547J2313; FABP 7; FABP7; FABP7_HUMAN; FABPB; Fatty Acid Binding Protein 7; Fatty acid binding protein 7 brain; Fatty acid binding protein brain; Fatty acid-binding protein 7; Fatty acid-binding protein, brain; Mammary derived growth inhibitor related ; Mammary-derived growth inhibitor related; MRG; OTTHUMP00000017119
Species
Homo sapiens (Human)
Expression Region
2-132
Target Protein Sequence
VEAFCATWK LTNSQNFDEY MKALGVGFAT RQVGNVTKPT VIISQEGDKV VIRTLSTFKN TEISFQLGEE FDETTADDRN CKSVVSLDGD KLVHIQKWDG KETNFVREIK DGKMVMTLTF GDVVAVRHYE KA
Protein Length
Full Length of Mature Protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
B-FABP could be involved in the transport of a so far unknown hydrophobic ligand with potential morphogenic activity during CNS development. It is required for the establishment of the radial glial fiber system in developing brain, a system that is necessary for the migration of immature neurons to establish cortical layers.
Gene References into Functions
  1. Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7. PMID: 28435883
  2. BLBP was highly expressed in glioblastoma tissues.Increased BLBP expression in glioblastoma is associated with poor survival.BLBP mediates the proliferation of human glioblastoma cells by regulating ERK1/2 signaling pathway. PMID: 29288341
  3. Data indicate that the levels of fatty acid binding protein 7 (FABP7) dramatically decreased during passage of the renal cell carcinomas (RCCs) cell line TUHR14TKB. PMID: 28292269
  4. FABP7 is overexpressed in clear cell renal cell carcinoma and promotes cell growth by the activation of ERK and Stat3 signaling pathways PMID: 25192834
  5. FABP7 and HMGCS2 may have roles in apocrine differentiation categorizing apocrine carcinoma of the breast PMID: 25389781
  6. The mRNA/protein expressions of FABP7 was lower in the stenotic colon segment tissue than in the normal colon segment tissue of Hirschsrung disease patients. PMID: 24966941
  7. These results suggest an important role of Rev-erbalpha and Fabp7 in adult neurogenesis. PMID: 24932636
  8. identified 98 transposable element-FABP7 gene chimeric transcripts that were exclusively expressed in primary diffuse large B-cell lymphoma (DLBCL) cases and confirmed several in DLBCL-derived cell lines PMID: 25114248
  9. FABP7 and FABP5 are differentially expressed in oligodendrocyte lineage cells and regulate their proliferation and/or differentiation. PMID: 24114376
  10. Our data introduces FABP7 as a marker for glioma stem cells and further highlights its possible significance for glioma diagnosis and treatment. PMID: 24274717
  11. Report feasibility of detecting B-FABP as biomarker for ischemic brain damage during extrcorporeal circulation in coronary artery bypass grafting patients. PMID: 23020859
  12. FABP7 is almost exclusively expressed in neurospheres and not in the adherent cells, derived from the same glioblastoma tumor. PMID: 23284888
  13. A fatty acid-binding protein 7/RXRbeta pathway enhances survival and proliferation in triple-negative breast cancer. PMID: 22322885
  14. Considerable heterogeneity in expression patterns of FABP7 within breast cancer elates to differences in biological behaviour especially in basal-like breast cancer. PMID: 22562177
  15. identified its binding target by proteomic analysis as fatty acid binding protein 7 (FABP7), also known as brain lipid binding protein) which is highly expressed in neural stem cells and localized in the cytoplasm PMID: 22689954
  16. These data provide the first evidence of direct transactivation of the FABP7 proximal promoter by PAX6 and suggest a synergistic mechanism for PAX6 and other co-factor(s) in regulating FABP7 expression in malignant glioma. PMID: 22583899
  17. Data show that three putative FABP7 promoter regions drive reporter gene expression in renal cell carcinoma cell lines, but not in the HEK293 cell line. PMID: 21771320
  18. expression of BLBP in activated astrocytes negatively correlates with disease duration and in parallel with remyelination failure PMID: 21620951
  19. BFABP is involved in cell proliferation and migration of human renal carcinoma cells. PMID: 21399875
  20. High FABP7 is associated with malignant glioma. PMID: 20834042
  21. We have identified a novel subgroup of basal phenotype (BP) class of breast cancers showing FABP7 expression that have significantly better clinical outcome. PMID: 19590950
  22. this study is the first to demonstrate overexpression of FABP-7 in triple-negative breast cancers PMID: 19608352
  23. FABP7 may function as a tumor progression gene in melanoma PMID: 19587692
  24. overall structure exhibits the typical backbone conformation described for other members of the FABP family, consisting of antiparallel beta-strands that form two almost orthogonal beta-sheets, a helix-turn-helix motif and a short N-terminal helical loop PMID: 12479569
  25. BLBP, stimulated by Ras-independent pathways, regulates Schwann cell-axon interactions in normal peripheral nerve and peripheral nerve tumors. PMID: 12612091
  26. Overexpression of FABP7 in Down syndrome fetal brains. PMID: 12771203
  27. data indicate that MRG is a mediator of the differentiating effects of pregnancy on breast epithelium PMID: 12975368
  28. A possible mechanism for the association of nuclear FABP7 & poor prognosis of glioblastoma multiforme is that nuclear FABP7 may be induced by EGFR activation to promote migration of GBM tumor cells. PMID: 16623952
  29. relation between FABP7, astrocytic features, invasion and poor prognosis and suggests that EGFR amplification is associated with nuclear translocation of FABP7. PMID: 17415524
  30. There were not significant difference in B-FABP expression between ductal infiltrating carcinoma and benign tissue in human breast cancer. PMID: 17428383
  31. Upregulation of FABP7 in renal cell carcinoma was confirmed by quantitative RT-PCR. PMID: 17646957
  32. B-FABP expression in malignant glioma cells is accompanied by the appearance of radial glial-like properties, as well as reduced transformation. B-FABP depletion results in decreased migration, reduction in cell processes, & a more transformed phenotype. PMID: 17898869
  33. Decreased expression of FABP-7 in fetal cystic adenomatoid malformation (CCAM) suggests FABP-7 may have a role in pulmonary development and in the pathogenesis of CCAM. PMID: 18391847
  34. Both in vitro Reelin treatment and overexpression of Notch-1 intracellular domain induced BLBP expression and a radial glial phenotype in an immortalized human neural progenitor cell line, isolated from the cortex of 14 weeks old fetus PMID: 18593473
  35. High expression of FABP7 is associated with melanoma PMID: 18826602
  36. NFI family of transcription factors plays a key role in the regulation of both the B-FABP and GFAP genes in malignant glioma cells. PMID: 19540848
  37. Increases tumor cell motility in vitro and over-expression is associated with poor prognosis in glioblastoma patients PMID: 15827123
  38. Functional analysis in mice. PMID: 12975368

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Subcellular Location
Cytoplasm.
Protein Families
Calycin superfamily, Fatty-acid binding protein (FABP) family
Tissue Specificity
Expressed in brain and other neural tissues.
Database Links

HGNC: 3562

OMIM: 602965

KEGG: hsa:2173

STRING: 9606.ENSP00000357429

UniGene: Hs.26770

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