GORASP2 Antibody

Code CSB-PA002804
Size US$167
Image
  • Western Blot analysis of LOVO cells using GRASP55 Polyclonal Antibody
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Product Details

Uniprot No. Q9H8Y8
Target Names GORASP2
Alternative Names AW552058 antibody; DKFZp434D156 antibody; FLJ13139 antibody; Golgi phosphoprotein 6 antibody; Golgi reassembly stacking protein 2 antibody; Golgi reassembly stacking protein 2; 55kDa antibody; Golgi reassembly stacking protein of 55 kDa antibody; Golgi reassembly-stacking protein 2 antibody; Golgi reassembly-stacking protein of 55 kDa antibody; GOLPH2 antibody; GOLPH6 antibody; GORASP2 antibody; GORS2_HUMAN antibody; GRASP55 antibody; GRS2 antibody; p59 antibody; RP23-428O15.1 antibody
Raised in Rabbit
Species Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from the Internal region of Human GRASP55.
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Isotype IgG
Purification Method The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Form Liquid
Tested Applications WB, IHC, ELISA
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Protocols Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
ELISA Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after mitotic breakdown. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA.
Gene References into Functions
  1. Results demonstrate a critical role for GRASP55 and GRASP65 in maintaining the stacked structure of the Golgi, which is required for accurate posttranslational modifications in the Golgi. Additionally, the GRASP knockout cell lines developed in this study will be useful tools for studying the role of GRASP proteins in other important cellular processes. PMID: 28814501
  2. binding site at the cleft between the PDZ1 and PDZ2 domains of GRASP65 is dominated by hydrophobic interactions with GM130 that are not observed in the GRASP55-Golgin45 complex PMID: 28049725
  3. GRASP55 interacts with CD83 shortly after induction of dendritic cells maturation. PMID: 25701785
  4. Cisternal-specific functions of GRASP65 and GRASP55 in continuity, compartmentalization, and function of the Golgi ribbon. PMID: 24227884
  5. propose that GRASP55/65 are negative regulators of exocytic transport and that this slowdown helps to ensure more complete protein glycosylation in the Golgi stack and proper sorting at the trans-Golgi network PMID: 23552074
  6. GRASP55 may function as an adaptor protein coupling MT1-MMP with furin, thus leading to the activation of the zymogen. PMID: 20608975
  7. These results demonstrate that GRASP55 and GRASP65 stack mammalian Golgi cisternae via a common mechanism. PMID: 20083603
  8. Data demonstrate that both GRASP55 and 65 are needed for the efficient transport to and through the Golgi complex, thus highlighting a novel role for the GRASPs in membrane trafficking. PMID: 19840934
  9. GRASP65 is an important structural component required for maintenance of Golgi apparatus integrity PMID: 11815631
  10. MEK1/ERK regulation of GRASP55-mediated Golgi linking is a control point in cell cycle progression PMID: 18434598
  11. GRASP55 forms an effector complex for the small GTPase rab2, together with a conserved coiled-coil protein golgin-45 (JEM-1). PMID: 11739401

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Subcellular Location Golgi apparatus membrane, Lipid-anchor, Membrane, Peripheral membrane protein, Membrane, Lipid-anchor
Protein Families GORASP family
Database Links

HGNC: 17500

OMIM: 608693

KEGG: hsa:26003

STRING: 9606.ENSP00000234160

UniGene: Hs.431317

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