IKZF2 Antibody

Code CSB-PA916923
Size US$297
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  • Western blot analysis of extracts from HeLa cells, using IKZF2 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) IKZF2 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
ANF1A2 antibody; HELIOS antibody; IKAROS family zinc finger 2 antibody; Ikaros family zinc finger protein 2 antibody; IKZF 2 antibody; IKZF2 antibody; IKZF2_HUMAN antibody; MGC34330 antibody; Zinc finger DNA binding protein Helios antibody; Zinc finger protein Helios antibody; Zinc finger protein subfamily 1A 2 antibody; ZNF1A2 antibody
Raised in
Species Reactivity
Synthesized peptide derived from internal of Human IKZF2.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Associates with Ikaros at centromeric heterochromatin.
Gene References into Functions
  1. The results suggested that increased methylation of Foxp3 Treg-specific demethylated region sequence and altered Helios gene expression in peripheral whole blood may have a role in the pathogenesis of rheumatoid arthritis via their effects on Regulatory T cell stability. PMID: 29851536
  2. Helios mRNA is down-regulated in Treg cells of patients with hypertension. PMID: 30074152
  3. mRNA expression of Helios was decreased in CD4+ T cells from patients with acute coronary syndrome. PMID: 29259350
  4. High expression of TIGIT and Helios identifies CD4+ T cells with impaired immunological functions, primarily among patients with an advanced stage of Sezary syndrome. PMID: 27592800
  5. The results show that high vs. low expression of Nrp-1 or Helios does not unequivocally identify Treg clones of thymic or peripheral origin. PMID: 26495986
  6. Helios could be considered a more reliable marker for distinguishing thymic derived Regulatory T (tTreg) cells or peripherally induced Treg cells than Nrp1. PMID: 25586548
  7. expression is not affected in diGeorge syndrome PMID: 25008482
  8. Forkhead box protein 3(+) regulatory T cells and Helios(+) subset in perinatally acquired HIV. PMID: 25425428
  9. Ectopic expression of ATL-type Helios isoform as well as knockdown of normal Helios or Ikaros promoted T-cell growth. PMID: 23600753
  10. Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus. PMID: 23264341
  11. large number of ex vivo expanded functional Treg can be obtained from long-term T1D patients, although fewer expanded Treg expressed a high level of Helios PMID: 23409157
  12. A differential role for monocyte subsets in control of Helios(+/-) Treg development that is mediated by distinct inflammatory cytokines. PMID: 23365462
  13. Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans. PMID: 23359504
  14. Presence of Helios-positive regulatory T (Treg) cells may maintain susceptibility to helminth infection on the C57BL/6 mouse background. PMID: 22753928
  15. Data found that Helios-negative T cells are enriched for naive T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions. PMID: 21918685
  16. Expanded peripheral FoxP3+ Tregs in untreated renal cell carcinoma patients co-express Helios. Interestingly, IL-2 administration results in expansion of FoxP3+Helios+ natural Tregs (nTregs) significantly more than FoxP3+Helios- iTregs. PMID: 21570917
  17. found that suppression of Helios message in CD4(+)CD25(+) T cells significantly attenuates their suppressive function. PMID: 20226531
  18. Novel short isoforms of Helios are overexpressed in a patient with T-cell acute lymphoblastic leukemia and may contribute to the development of T-cell malignancies. Data for unaltered Helios indicates tumor suppressor function. PMID: 11937265
  19. suggest a critical role for Helios in the mechanism of leukemogenesis PMID: 17297655

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Subcellular Location
Protein Families
Ikaros C2H2-type zinc-finger protein family
Database Links

HGNC: 13177

OMIM: 606234

KEGG: hsa:22807

STRING: 9606.ENSP00000410447

UniGene: Hs.604950

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