IKZF2 Antibody

1. The results suggested that increased methylation of Foxp3 Treg-specific demethylated region sequence and altered Helios gene expression in peripheral whole blood may have a role in the pathogenesis of rheumatoid arthritis via their effects on Regulatory T cell stability. PMID: 29851536
2. Helios mRNA is down-regulated in Treg cells of patients with hypertension. PMID: 30074152
3. mRNA expression of Helios was decreased in CD4+ T cells from patients with acute coronary syndrome. PMID: 29259350
4. High expression of TIGIT and Helios identifies CD4+ T cells with impaired immunological functions, primarily among patients with an advanced stage of Sezary syndrome. PMID: 27592800
5. The results show that high vs. low expression of Nrp-1 or Helios does not unequivocally identify Treg clones of thymic or peripheral origin. PMID: 26495986
6. Helios could be considered a more reliable marker for distinguishing thymic derived Regulatory T (tTreg) cells or peripherally induced Treg cells than Nrp1. PMID: 25586548
7. expression is not affected in diGeorge syndrome PMID: 25008482
8. Forkhead box protein 3(+) regulatory T cells and Helios(+) subset in perinatally acquired HIV. PMID: 25425428
9. Ectopic expression of ATL-type Helios isoform as well as knockdown of normal Helios or Ikaros promoted T-cell growth. PMID: 23600753
10. Foxp3+ Helios+ regulatory T cells are expanded in active systemic lupus erythematosus. PMID: 23264341
11. large number of ex vivo expanded functional Treg can be obtained from long-term T1D patients, although fewer expanded Treg expressed a high level of Helios PMID: 23409157
12. A differential role for monocyte subsets in control of Helios(+/-) Treg development that is mediated by distinct inflammatory cytokines. PMID: 23365462
13. Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans. PMID: 23359504
14. Presence of Helios-positive regulatory T (Treg) cells may maintain susceptibility to helminth infection on the C57BL/6 mouse background. PMID: 22753928
15. Data found that Helios-negative T cells are enriched for naive T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions. PMID: 21918685
16. Expanded peripheral FoxP3+ Tregs in untreated renal cell carcinoma patients co-express Helios. Interestingly, IL-2 administration results in expansion of FoxP3+Helios+ natural Tregs (nTregs) significantly more than FoxP3+Helios- iTregs. PMID: 21570917
17. found that suppression of Helios message in CD4(+)CD25(+) T cells significantly attenuates their suppressive function. PMID: 20226531
18. Novel short isoforms of Helios are overexpressed in a patient with T-cell acute lymphoblastic leukemia and may contribute to the development of T-cell malignancies. Data for unaltered Helios indicates tumor suppressor function. PMID: 11937265
19. suggest a critical role for Helios in the mechanism of leukemogenesis PMID: 17297655

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HGNC: 13177

OMIM: 606234

KEGG: hsa:22807

STRING: 9606.ENSP00000410447

UniGene: Hs.604950