Recombinant Human C-X-C motif chemokine 16(CXCL16),partial

Code CSB-YP863959HU
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Source Yeast
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Code CSB-EP863959HU
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Source E.coli
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Code CSB-EP863959HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP863959HU
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Source Baculovirus
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Code CSB-MP863959HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names CXCL16
Uniprot No. Q9H2A7
Alternative Names C-X-C motif chemokine 16; Chemokine (C X C motif) ligand 16; Chemokine; CXC motif; ligand 16; CXC chemokine ligand 16; Cxcl16; CXCLG16; CXL16_HUMAN; Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; SCYB16; Small inducible cytokine B16 precursor; Small-inducible cytokine B16; SR-PSOX; SRPSOX; Transmembrane chemokine CXCL16; UNQ2759/PRO6714
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Acts as a scavenger receptor on macrophages, which specifically binds to OxLDL (oxidized low density lipoprotein), suggesting that it may be involved in pathophysiology such as atherogenesis. Induces a strong chemotactic response. Induces calcium mobilization. Binds to CXCR6/Bonzo.
Gene References into Functions
  1. demonstrate that macrophages can promote the migration and invasion of ovarian carcinoma cells by affecting the CXCL16/CXCR6 pathway PMID: 30049511
  2. activation of cancer-associated fibroblasts and expression of CXCL16, shown to be a monocyte chemoattractant. PMID: 27725631
  3. Enhanced CXCL16 expression in lung cancer tissue promoted the proliferation and invasion of lung cancer cells. CXCL16 might promote proliferation and invasion of lung cancer by regulating the NF-kappaB pathway. PMID: 29353287
  4. increased plasma sCXCL16 might be implicated in the pathogenesis of immune thrombocytopenia and have a relationship with Th1/Th2 imbalance. PMID: 28886489
  5. Serum CXCL16 levels are significantly increased in patients with gallstone, and are independently associated with liver injury in Chinese population, suggesting that CXCL16 may be a biomarker of liver injury in subjects with gallstone or NAFLD. Hepatic CXCL16 mRNA and protein levels were also significantly increased in gallstone patients PMID: 28722105
  6. IFN-gamma, CXCL16 and uPAR are promising as effective biomarkers of disease activity, renal damage, and the activity of pathological lesions in systemic lupus erythematosus. PMID: 28628472
  7. Data showed that reverse signaling via CXCL16 promotes migration in CXCL16-expressing melanoma and glioblastoma cells, but does not affect proliferation or protection from chemically-induced apoptosis. PMID: 28698473
  8. Study showed, for the first time, highly significant relationships of circulating CXCL16 level with cardiac injury markers in dialysis patients. PMID: 28633141
  9. Women with gestational diabetes mellitus and preeclampsia had a dysregulated CXC chemokine ligand 16 during pregnancy, and in gestational diabetes mellitus, the increase in CXC chemokine ligand 16 early in pregnancy and after 5 years was strongly associated with their lipid profile. PMID: 28856928
  10. Data suggest that primary cells from papillary renal cell carcinoma secrete the chemokines IL8, CXCL16, and chemerin; these chemokines attract primary human monocytes and induce shift/transdifferentiation in monocytes toward M2 macrophage/foam cell phenotype. (IL8 = interleukin-8; CXCL16 = C-X-C motif chemokine ligand 16) PMID: 28759013
  11. Our study demonstrated that CXCL16-CXCR6 mediates CD8(+) T-cell skin trafficking under oxidative stress in patients with vitiligo, and CXCL16 expression in human keratinocytes induced by ROS is, at least in part, caused by unfolded protein response activation PMID: 27826097
  12. eGFR and serum albumin had an independent and significant negative correlation with plasma CXCL16 in diabetic kidney disease. PMID: 27665581
  13. The expression of CXCL16 and and its receptor, CXCR6, their immunolocalization in disc tissue and their presence following exposure of cultured human annulus fibrosus cells to proinflammatory cytokines are reported. PMID: 27869573
  14. Inflammation contributed to foam cell formation in the radial arteries of ESRD patients via activation of the CXCL16/CXCR6 pathway, which may be regulated by P2X7R. PMID: 27877078
  15. CXCL16 single nucleotide polymorphisms significantly impacted myocardial infarction risk in a Chinese Han population. PMID: 28286356
  16. Transmembrane-CXCL16 specifically acts as a receptor for soluble-CXCL16 in human meningioma cells. PMID: 27784296
  17. Higher levels CXCL16 may be a biomarker for predicting stroke incidence and might contribute to plaque destabilization. PMID: 27355560
  18. CXCL16 is released into the circulation as a result of cardiac surgery and that high post-operative CXCL16 levels are associated with an increased severity of post-operative organ dysfunctions. PMID: 26499307
  19. Serum CXCL16 may be a novel biomarker for the diagnosis of patients with diabetic coronary artery disease. PMID: 27098626
  20. High CXCL16 expression is associated with prostate cancer. PMID: 26799186
  21. In conclusion, rheumatoid arthritis synovial fibroblasts were activated by CXCL16 to produce RANKL via pathways involving JAK2/STAT3 and p38/MAPK PMID: 26621504
  22. Our data suggest that CXCL16 induces angiogenesis in autocrine manner via ERK, Akt, p38 pathways and HIF-1alpha modulation PMID: 26707275
  23. Cell proliferation enhancing and anti-apoptosis activity requires the intracellular domain and apparently the dimerization of the transmembrane chemokine ligand. PMID: 26796342
  24. Wnt5a-Ror2 signaling enhances expression and secretion of CXCL16 in mesenchymal stem cells thereby activating CXCR6 expressed on tumor cells to promote proliferation. PMID: 26708384
  25. Endothelial CXCL16's action on platelets is not limited to platelet activation. Immobilised CXCL16 also acts as a potent novel platelet adhesion ligand, inducing platelet adhesion to the human vessel wall. PMID: 25904061
  26. HMGB-1, CXCL16, miRNA-30a, and urinary TGF-ss1 were highly expressed in PNS patients and may play important roles in the pathogenesis and development of PNS. PMID: 26345917
  27. high protein expression of CXCL16 and high protein co-expression of CXCL16/CXCR6 in prostate cancer were independent predictors for a worse clinical outcome PMID: 26272362
  28. PPARG rs1152002, AGTR1 rs5186, CXCL16 rs3744700 and LGALS2 rs7291467 polymorphisms may be closely related to the development of coronary heart disease PMID: 26045830
  29. These results indicate that MEK inhibitor diminishes Nasopharyngeal carcinoma cell proliferation and NPC-induced osteoclastogenesis via modulating CCL2 and CXCL16 expressions. PMID: 26058873
  30. we examined the expression of CXCL16 and CXCR6 and their relations to prognosis in 335 unselected patients with NSCLC, and investigated possible relationships with our previously studied immunologic and angiogenic markers PMID: 26021984
  31. CXCL16 T123V181 haplotype is a moderate genetic risk factor for the development of carotid plaque. PMID: 25142184
  32. Serum CXCL16 is increased in severe pancreatitis with infected pancreatic necrosis and identifies patients who benefit from surgical necrosectomy PMID: 25661686
  33. injured hepatocytes up-regulated CXCL16 expression, indicating that scavenging functions of CXCL16 might be additionally involved in the pathogenesis of NAFLD. PMID: 25372401
  34. CXCL16 and CXCR6 coexpression is associated with invasiveness of lung cancer. PMID: 24897301
  35. No significant association of the CXCL16 polymorphism was established either with soluble CXCL16 plasma levels or with clinical parameters and course of multiple sclerosis. PMID: 24854635
  36. CXCL16 expression is enhanced in inflammatory cardiomyopathy and is an independent predictor of death in patients with heart failure. PMID: 25223819
  37. Elevated serum sCXCL16 levels were discovered in the systemic lupus erythematosus patients with cutaneous and renal involvement. PMID: 25015061
  38. Silencing CXCL16 could phenocopy the effects of miR-451 on phenotypes of osteosarcoma cells. PMID: 25391425
  39. High circulating CXCL16 levels are associated to human kidney and cardiovascular disease and urinary CXCL16 may increase in kidney injury. PMID: 24861945
  40. Serum CXCL16 may be an indicator of renal injury in subjects with type 2 diabetes mellitus. PMID: 24489966
  41. Serum CXCL16 was increased in patients with active Primary nephrotic syndrome and correlated with blood lipids, urine protein and immune and inflammation responses PMID: 24460887
  42. High serum sCXCL16 is a prognostic marker for poor survival of OC patients, possibly reflecting ADAM-10 and ADAM-17 pro-metastatic activity. PMID: 24518602
  43. CXCL16, iNKT cell-associated cell marker Valpha24, and CD1d were significantly upregulated in esophageal biopsies from EoE patients and correlated with the expression of inflammatory mediators associated with allergy. PMID: 24513807
  44. CXCL16 could be a novel biomarker and potential predictor of disease activity in MS. PMID: 24069377
  45. CXCL16/CXCR6 interaction may play an important role in modifying the response of pDCs to environmental danger signals PMID: 24302814
  46. Our results suggest that the CXCL16/CXCR6 axis appears to be important in the progression of Ewing sarcoma family tumor PMID: 24507753
  47. Data suggest that plasma level of CXCL16 is up-regulated in subjects with metabolic syndrome and correlates with severity of carotid atherosclerosis (i.e., intima-media thickness and plaque index). PMID: 23398954
  48. Erythrocyte adhesion to immobilized platelets requires phosphatidylserine at the erythrocyte surface and CXCL16 as well as CD36 expression on platelets. PMID: 24284794
  49. CXCL16, inversely correlated with CD99 expression in Hodgkin Reed-Sternberg (H/RS) cells. PMID: 23743627
  50. Suggest that expression of transmembrane CXCL16 on surface of plasmacytoid dendritic cell might contribute to high serum IFN-alpha levels seen in patients with Behcet's disease. PMID: 24064021

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Subcellular Location Cell membrane; Single-pass type I membrane protein. Secreted. Note=Also exists as a soluble form.
Protein Families Intercrine alpha (chemokine CxC) family
Tissue Specificity Expressed in T-cell areas. Expressed in spleen, lymph nodes, lung, kidney, small intestine and thymus. Weak expression in heart and liver and no expression in brain and bone marrow.
Database Links

HGNC: 16642

OMIM: 605398

KEGG: hsa:58191

STRING: 9606.ENSP00000293778

UniGene: Hs.745037

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