Recombinant Human Calcium/calmodulin-dependent protein kinase type II subunit gamma (CAMK2G)

1. point mutation R292P sufficient to disrupt gene expression and spatial learning PMID: 29934532
2. The data suggest T287 autophosphorylation regulates substrate gating, an intrinsic property of the catalytic domain, which is amplified within the multivalent architecture of the calcium/calmodulin-dependent protein kinase II holoenzyme. PMID: 29391954
3. These findings indicate that the CaMKII-mediated GluA1 phosphorylation of S567 and S831 is critical for P2X2-mediated AMPAR internalization and ATP-driven synaptic depression. PMID: 27624155
4. Laminin is instructive and CaMKII is non-permissive for the formation of complex aggregates of acetylcholine receptors on myotubes in culture. PMID: 27964993
5. A new molecular mechanism mediated by CAMK2gamma in intestinal epithelial cells during colitis-associated cancer (CAC) development, thereby providing a potential new therapeutic target for CAC. PMID: 28319059
6. oxidative stress activated the TRPM2-CaMKII cascade to further induce intracellular ROS production, which led to mitochondria fragmentation and loss of mitochondrial membrane potential PMID: 28007458
7. novel mechanism by which CAMK2gamma antagonizes mTORC1 activation during hepatocarcinogenesis PMID: 27819676
8. Demonstrate that calcium/CaMKIIgamma/AKT signaling can regulate apoptosis and autophagy simultaneously in colorectal cancer cells. PMID: 26803057
9. High CaMKIIgamma expression is associated with lung cancer. PMID: 25965829
10. Dysfunction in CaMKII-based signaling has been linked with a host of cardiovascular phenotypes including heart failure and arrhythmia, and CaMKII levels are elevated in human and animal disease models of heart disease. PMID: 25577293
11. Inhibition of CaMKII activity results in an upregulation of CaMKIV mRNA and protein in leukemia cell lines. PMID: 25446257
12. CAMKIIgamma, HSP70 and HSP90 transcripts are differentially expressed in chronic myeloid leukemia cells from patients with resistant mutated disease. PMID: 24206096
13. CaMKII-dependent microtube polymerization may be responsible for the enhanced uptake of PEI/ON complexes in A549 cells under oxidative stress conditions. PMID: 24634301
14. Our data suggest that berbamine and its derivatives are promising agents to suppress liver cancer growth by targeting CAMKII PMID: 23960096
15. CaMKII overexpression in mushroom body neurons increases activity dependent calcium responses. PMID: 23543616
16. it can be concluded that CaMKII regulates the activity of ASIC1, which is associated with the ability of GBM cells to migrate. PMID: 24100685
17. When inhibiting CaMKII, B-cell activating factor (BAFF) is attenuated and mediates protein phosphatase (PP)2A-Erk1/2 signaling and B-cell proliferation. PMID: 24269630
18. the chronic gain-of-function defect in RyR2 due to CaMKII hyperphosphorylation is a novel mechanism that contributes to pathogenesis of type 2 diabetes PMID: 23516528
19. results show that CAMKII and calmodulin contribute to IKK complex activation and thus to the induction of NF-kappaB in response to H. pylori infection PMID: 23463379
20. Activated CaMK-II interacts with the C-terminal domain of diacylglycerol lipase-alpha (DGLalpha) and inhibits DGLalpha activity. PMID: 23502535
21. Data indicate that CaMKII gamma as a specific and critical target of berbamine for its antileukemia activity. PMID: 23074277
22. These findings revealed a fundamental role of CaMKII in the enteric nervous system. PMID: 22952977
23. CaMKII T286A showed a mildly but significantly reduced rate of Ca(2+)/CaM-stimulated phosphorylation for two different peptide substrates (to ~75-84% of wild type). PMID: 22615928
24. The CaMKII phosphorylation motif in the Nav1.5 DI-DII cytoplasmic loop is a critical point for proarrhythmic changes. PMID: 23008441
25. CaMKII was also necessary for the phosphorylation of Raf-1 at S338 by serum, fibronectin and Ras. PMID: 22592532
26. increases in Ca(2+) lead to CaMKII activation and subsequent Lck-dependent p66Shc phosphorylation on Serine 36. This event causes both mitochondrial dysfunction and impaired Ca(2+) homeostasis, which synergize in promoting Jurkat T-cell apoptosis. PMID: 21983898
27. we review the cellular colocalization of CaMKII isoforms with special regard to the cell-type specificity of isoform expression in brain--REVIEW PMID: 22612808
28. CaMKII binding to and phosphorylation of the NHE3 C terminus are parts of the physiologic regulation of NHE3 that occurs in fibroblasts as well as in the brush border of an intestinal Na(+)-absorptive cell. PMID: 22371496
29. study demonstrates that premitotic condensation involves the activation of ClC-3 by Ca(2+)/calmodulin-dependent protein kinase II in glioma cells PMID: 22049206
30. study shows CaMKII is recruited to the immunological synapse where it interacts with and phosphorylates Bcl10; propose a mechanism whereby Ca(2+) signals can be integrated at the immunological synapse through CaMKII-dependent phosphorylation of Bcl10 PMID: 21513986
31. Ca(2+)/calmodulin-dependent kinase II participate in control of cell cycle progression and survival of irradiated CML cells. PMID: 21063097
32. These results indicated that PP6 and CaMKII regulated apoptosis by controlling the expression level of p27. PMID: 20851109
33. The interaction between CaMKII and its binding proteins was altered by the phosphorylation state of both the CaMKII and the partner. PMID: 20060891
34. CaMKII is a molecular link translating intracellular calcium changes, which are intrinsically associated with glioma migration, to changes in ClC-3 conductance required for cell movement PMID: 20139089
35. Our results suggest a first observation that CaMKII regulates TRAIL-mediated apoptosis of fibroblast-like synovial cells through Akt, standing an upstream of caspase-8-dependent cascades. PMID: 20149311
36. Study further supports self-aggregation of CaMKII holoenzymes as the underlying mechanism that involves inter-holoenzyme T286-region/T-site interaction. PMID: 19840793
37. cloning, genomic structure and detection of variants in subjects with Type II diabetes PMID: 12032636
38. CaMKIIgamma is necessary to suppress MCAK depolymerase activity in vivo. PMID: 15775983
39. A transgenic, constitutively active, Ca2+-independent form of CaMKgamma reduces positive selection of T cells by maintaining association of SHP-2 with the T cell receptor (TCR) complex, and halting TCR signaling. PMID: 16002660
40. Amphetamine in a cell line induces a robust increase in cytosolic Ca2+ and concomitant activation of calcium/calmodulin-dependent protein kinase II (CaMKII). PMID: 17032905
41. Significant cross-talk between calcium and retinoic acid signaling pathways regulates the differentiation of myeloid leukemia cells. PMID: 17431504
42. insulin in the presence of Angiotensin II inhibits protein phosphatase-2A (PP-2A) and stimulates autonomous CaM kinase II activities and thus vascular smooth muscle migration PMID: 17553505
43. IGF-II/mannose-6-phosphate receptor signaling induced cell hypertrophy and atrial natriuretic peptide/BNP expression via Galphaq interaction and protein kinase C-alpha/CaMKII activation in H9c2 cardiomyoblast cells. PMID: 18434368
44. CaMKIIgamma is a critical regulator of multiple signaling networks regulating the proliferation of myeloid leukemia cells PMID: 18483256
45. In Turner yndrome, loss of voltage-dependent inactivation is an upstream initiating event for arrhythmia phenotypes that are ultimately dependent on CaMKII activation. PMID: 19001023
46. increased RyR2-dependent Ca2+ leakage due to enhanced CaMKII activity is an important downstream effect of CaMKII in individuals susceptible to AF induction. PMID: 19603549
47. P2X7 receptor-triggered signalling pathways that regulate neurite formation in neuroblastoma cells. PMID: 19682070

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HGNC: 1463

OMIM: 602123

KEGG: hsa:818

STRING: 9606.ENSP00000319060

UniGene: Hs.523045