Recombinant Human E3 SUMO-protein ligase EGR2 (EGR2)

1. Low EGR2 expression is associated with hepatocellular carcinoma. PMID: 28542387
2. The study suggests that acetylation of EGR2 is regulated independently of nucleosome remodeling and deacetylase. PMID: 28576496
3. Egr2-driven cell surface proteins LAG-3 and 4-1BB can identify dysfunctional tumor antigen-specific CD8(+) TIL. PMID: 28115575
4. Egr2 and Egr3 have emerged as regulatory molecules that suppress excessive immune responses. Mice deficient for Egr2 and Egr3 develop a lupus-like disease with dysregulated activation of effector T cells. Egr2 and Egr3 confer suppressive activity to CD4(+) T cells and regulate the production of inhibitory cytokines such as IL-10 and TGF-beta1. PMID: 27856665
5. Analysis of consensus EGR-binding elements (EBEs) showed that the immediate early response 3 gene (IER3) is a novel transcriptional target gene of EGR2 as confirmed by the luciferase assay, electrophoretic mobility-shift assay (EMSA), chromatin immunoprecipitation (ChIP), and western blot analysis. PMID: 27890615
6. In the PPI network, genes may be involved in Down syndrome (DS) by interacting with others, including nuclear receptor subfamily 4 group A member 2 (NR4A2)early growth response (EGR)2 and NR4A2EGR3. Therefore, RUNX1, NR4A2, EGR2, EGR3 and ID4 may be key genes associated with the pathogenesis of DS. PMID: 27667480
7. EGR2 mutation presents as an axonal Charcot-Marie-Tooth phenotype with variable severity. PMID: 26204789
8. MicroRNA20a promotes the proliferation and cell cycle of human osteosarcoma cells by suppressing EGR2 expression. PMID: 26238942
9. These results suggested that EGR2 overexpression has a pivotal role in the downregulation of cytokines implicated in the pathophysiology of Guillain-Barre syndrome PMID: 26718337
10. A recurrent mutation was identified in EGR2 which appears to be associated with the pathogenesis of schizophrenia. PMID: 26119399
11. Knock-down of EGR2 with siRNA was demonstrated to have a similar effect as the over-expression of miR-330-3p in NSCLC cell lines PMID: 25935837
12. Dysregulated Egr-2 is observed in some human autoimmune disorders. PMID: 25381473
13. EGR2 knockdown inhibited proliferation, clonogenicity and spheroidal growth in vitro and induced regression of Ewing sarcoma xenografts. PMID: 26214589
14. transcription factor early growth response gene-2 is a novel molecular switch regulating known immunomodulatory molecules in human mesenchymal stem cells. PMID: 24007274
15. Overexpression of EGR2 significantly attenuated the oncogenic effect of miR-20a. PMID: 23924943
16. Lack of association of EGR2 variants with bipolar disorder in Japanese population. PMID: 23747400
17. EGR2 and EGR3 are regulated by NFkappaB and MAPK signalling pathways downstream of TNFalpha stimulation in breast adipose fibroblasts, and this in turn is upstream of CYP19A1 transcription via PI.4 PMID: 23485457
18. data suggest a tendency of gender-specific association of EGR2 and EGR4 in schizophrenia. PMID: 22691714
19. Charcot-Marie-Tooth neuropathy due to a novel EGR2 gene mutation exhibits a mild phenotype in a Czech family. PMID: 22546699
20. Egr2 expression is translationally regulated via an IRES element, which is responsive to an inflammatory environment. PMID: 22915601
21. we report on a heterozygous mutation in EGR2 in a family with a mild demyelinating form of adult-onset Charcot-Marie-Tooth disease PMID: 22734907
22. Combined with a plausible biological function of EGR2, the EGR2 gene is a possible susceptibility gene in bipolar disorder. PMID: 22089088
23. data further demonstrate the major role of the myelinating Schwann cell element in the regulation of EGR2 expression in the human peripheral nervous system PMID: 22522483
24. Results identify a mutation in EGR2 in a Charcot-Marie-tooth disease patient with hypersensitivity to vincristine. PMID: 22271166
25. Common variants near TARDBP and EGR2 are associated with susceptibility to Ewing sarcoma. PMID: 22327514
26. Krox20 functions as a SUMO ligase for its coregulators--the Nab proteins--and that Nab sumoylation negatively modulates Krox20 transcriptional activity in vivo. PMID: 21836637
27. TGF-beta3 regulated Egr-2 gene expression in uterine leiomyoma cells. PMID: 21703609
28. these findings suggest that Egr-2 plays an important nonredundant role in the pathogenesis of fibrosis. PMID: 21514423
29. EGR2 is a direct transcriptional target of p53 family that can in part mediate the p53-dependent apoptotic pathway. PMID: 21042708
30. Schwann cells expressed myelin proteins and Krox20 which is an important regulator of peripheral myelination. PMID: 21057508
31. EGR2 is a genetic risk factor for Systemic lupus erythematosus (SLE), in which increased gene expression may contribute to SLE pathogenesis. PMID: 20194224
32. EGR2 mutation(amino aacid substitution) identifies a case of Charcot-Marie-Totth disease. PMID: 20513111
33. overexpression of miR-150 in gastric cancer could promote proliferation and growth of cancer cells at least partially through directly targeting the tumor-suppressor EGR2. PMID: 20067763
34. Frequency of mutations in the early growth response 2 gene associated with peripheral demyelinating neuropathies PMID: 12471219
35. EGR2 mutant D355V induces a Cx32 promoter, mutant R381H doesn't. A sequence located at -216, recognized by the wild-type and the mutant D355V recombinant proteins, is relevant for promoter transactivation. PMID: 12609493
36. we found that EGR2 could induce apoptosis in a large proportion of these lines by altering the permeability of mitochondrial membranes, releasing cytochrome c and activating caspase-3, -8, and -9. PMID: 12687019
37. This report detected a heterozygous Asp383Tyr mutation of EGR2 in one patient with severe CMT1, Dejerine-Sottas syndrome. PMID: 12736090
38. a possible molecular mechanism to account for down-regulation of EGR2 in tumor cells PMID: 14596916
39. Egr-2 and Egr-3 transcription is enhanced by Hepatitis B virus X protein, which induces fasL gene expression PMID: 15173177
40. A Charcot-Marie-Tooth syndrome in a family with a missense mutation in EGR2. PMID: 15947997
41. One novel de-novo mutation (Arg359Gln, R359Q) was identified in heterozygous state in a patient with a typical CMT1 phenotype, progressive moderate thoracolumbar scoliosis and without clinical signs of cranial nerve dysfunction. PMID: 16198564
42. Control of Krox20 transcription relies on three very long-range enhancer elements (A, B and C) that are conserved in chick, mouse and human genomes. PMID: 16495311
43. morphological studies in the context of the I268N homozygous recessive mutation affecting the NAB repressor binding site and the R359W dominant-negative mutation in the zinc-finger domain PMID: 17717711
44. Collectively, these data indicate that EGR2 is specifically upregulated by a parasite-derived secreted factor that is most likely a resident rhoptry protein. PMID: 18678671
45. Dysregulation of EGR2 and MeCP2 plays roles in in Rett syndrome and autism. PMID: 19000991
46. AIP2 regulates activation-induced T-cell death by suppressing EGR2-mediated FasL expression via the ubiquitin pathway PMID: 19651900

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HGNC: 3239

OMIM: 129010

KEGG: hsa:1959

STRING: 9606.ENSP00000242480

UniGene: Hs.1395